Correlated conformational events in EF-G and the ribosome regulate translocation (Q34380655)

1 August 2017

title

Correlated conformational events in EF-G and the ribosome regulate translocation (English)

1 reference

1 August 2017

James B Munro

1

1 reference

1 August 2017

Michael R Wasserman

2

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1 August 2017

Roger B Altman

3

1 reference

1 August 2017

Leyi Wang

4

1 reference

1 August 2017

Scott C Blanchard

5

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1 August 2017

language of work or name

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7 November 2010

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Nature Structural & Molecular Biology

1 August 2017

published in

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1 August 2017

volume

17

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1 August 2017

issue

12

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1 August 2017

page(s)

1470-1477

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A fast dynamic mode of the EF-G-bound ribosome.

1 August 2017

cites work

1 reference

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Elongation in translation as a dynamic interaction among the ribosome, tRNA, and elongation factors EF-G and EF-Tu

6 July 2018

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Spontaneous formation of the unlocked state of the ribosome is a multistep process

6 July 2018

1 reference

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Aminoglycoside activity observed on single pre-translocation ribosome complexes

6 July 2018

1 reference

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The A-Z of bacterial translation inhibitors

6 July 2018

1 reference

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The Structure of the Ribosome with Elongation Factor G Trapped in the Posttranslocational State

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Navigating the ribosome's metastable energy landscape

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Conformational changes in switch I of EF-G drive its directional cycling on and off the ribosome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Mitigating unwanted photophysical processes for improved single-molecule fluorescence imaging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Following movement of the L1 stalk between three functional states in single ribosomes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Ribosomal translocation: one step closer to the molecular mechanism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Structure of ratcheted ribosomes with tRNAs in hybrid states

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Visualization of the hybrid state of tRNA binding promoted by spontaneous ratcheting of the ribosome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Role of hybrid tRNA-binding states in ribosomal translocation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Spontaneous intersubunit rotation in single ribosomes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Following translation by single ribosomes one codon at a time.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

An oxygen scavenging system for improvement of dye stability in single-molecule fluorescence experiments

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

A Steric Block in Translation Caused by the Antibiotic Spectinomycin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Genetically encoded short peptide tags for orthogonal protein labeling by Sfp and AcpS phosphopantetheinyl transferases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Kinetically competent intermediates in the translocation step of protein synthesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Identification of two distinct hybrid state intermediates on the ribosome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

The hybrid state of tRNA binding is an authentic translation elongation intermediate

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Structures of the bacterial ribosome at 3.5 A resolution

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Mechanisms of elongation on the ribosome: dynamics of a macromolecular machine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

tRNA dynamics on the ribosome during translation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Restoration of single-channel currents using the segmental k-means method based on hidden Markov modeling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Locking and unlocking of ribosomal motions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

A ratchet-like inter-subunit reorganization of the ribosome during translocation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Large-scale movement of elongation factor G and extensive conformational change of the ribosome during translocation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Intermediate states in the movement of transfer RNA in the ribosome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Factor-free ("non-enzymic") and factor-dependent systems of translation of polyuridylic acid by Escherichia coli ribosomes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

The Inhibition of Ribosomal Translocation by Viomycin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Single-molecule structural dynamics of EF-G--ribosome interaction during translocation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

The antibiotic viomycin traps the ribosome in an intermediate state of translocation.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Conformational changes of the small ribosomal subunit during elongation factor G-dependent tRNA-mRNA translocation

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Ribosomal Proteins S12 and S13 Function as Control Elements for Translocation of the mRNA:tRNA Complex

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Peptidyl-tRNA regulates the GTPase activity of translation factors

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

An elongation factor G-induced ribosome rearrangement precedes tRNA-mRNA translocation

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Catalysis of ribosomal translocation by sparsomycin

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Rapid kinetic analysis of EF-G-dependent mRNA translocation in the ribosome

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Coupling of GTP hydrolysis by elongation factor G to translocation and factor recycling on the ribosome

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

The role of guanosine triphosphate in translocation reaction catalyzed by elongation factor G.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2997181

Coupling of ribosomal L1 stalk and tRNA dynamics during translation elongation

27 October 2018

1 reference

Conformationally Restricted Elongation Factor G Retains GTPase Activity but Is Inactive in Translocation on the Ribosome

31 March 2020

1 reference

Site-specific protein labeling by Sfp phosphopantetheinyl transferase

31 March 2020

1 reference

Formation of the ribosome-G factor-GDP complex in the presence of fusidic acid

31 March 2020

1 reference

Spontaneous, elongation factor G independent translocation of Escherichia coli ribosomes

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21057527

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NSMB.1925

1 reference

Dimensions Publication ID

1 August 2017

0 references

1 reference

1 August 2017

1 reference