Role of the BMK1/ERK5 signaling pathway: lessons from knockout mice (Q34363614)

1 August 2017

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title

Role of the BMK1/ERK5 signaling pathway: lessons from knockout mice (English)

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1 August 2017

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Masaaki Hayashi

1

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PubMed ID

15517128

1 August 2017

Jiing-Dwan Lee

series ordinal

2

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1 August 2017

28 October 2004

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Journal of Molecular Medicine

1 August 2017

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1 August 2017

82

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1 August 2017

12

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1 August 2017

800-808

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https://scigraph.springernature.com/pub.10.1007/s00109-004-0602-8

1 August 2017

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cites work

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Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

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Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development

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Mekk3 is essential for early embryonic cardiovascular development

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BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

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12 December 2020

Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure.

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Neurotrophins use the Erk5 pathway to mediate a retrograde survival response.

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Big mitogen-activated kinase regulates multiple members of the MEF2 protein family

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Activation of big mitogen-activated protein kinase-1 regulates smooth muscle cell replication

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Alterations in G protein and MAP kinase signaling pathways during cardiac remodeling in hypertension and heart failure

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Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults

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Requirement of the MADS-box transcription factor MEF2C for vascular development

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Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo

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12 December 2020

Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor

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12 December 2020

MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway

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12 December 2020

Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus

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Vascular smooth muscle cell proliferation requires both p38 and BMK1 MAP kinases

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12 December 2020

Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2

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Src and multiple MAP kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: comparison with acute mechanical stretch

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Cre-mediated gene deletion in the mammary gland

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Mammalian MAP kinase signalling cascades

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Fluid shear stress stimulates big mitogen-activated protein kinase 1 (BMK1) activity in endothelial cells. Dependence on tyrosine kinases and intracellular calcium

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Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control

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Pathophysiology of chronic heart failure

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ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expression

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Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

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12 December 2020

Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains

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12 December 2020

Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation

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12 December 2020

Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway

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12 December 2020

Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase

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12 December 2020

Prostate cancer in a transgenic mouse

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MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion

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Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

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Interleukins in atherosclerosis: molecular pathways and therapeutic potential

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Big mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis

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MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2 in fibroblasts.

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A network of mitogen-activated protein kinases links G protein-coupled receptors to the c-jun promoter: a role for c-Jun NH2-terminal kinase, p38s, and extracellular signal-regulated kinase 5.

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Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells

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12 December 2020

Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells

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12 December 2020

Components of a new human protein kinase signal transduction pathway

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12 December 2020

ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons

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12 December 2020

Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects

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12 December 2020

ERK5 and ERK2 cooperate to regulate NF-kappaB and cell transformation

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12 December 2020

Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy.

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12 December 2020

Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function.

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12 December 2020

Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C

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12 December 2020

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

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12 December 2020

The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF

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12 December 2020

Knockout of ERK5 causes multiple defects in placental and embryonic development

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12 December 2020

Primary structure of BMK1: a new mammalian map kinase

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12 December 2020

MEK kinase 3 directly activates MKK6 and MKK7, specific activators of the p38 and c-Jun NH2-terminal kinases

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12 December 2020

MEF2C regulates c‐Jun but not TNF‐α gene expression in stimulated mast cells

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12 December 2020

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

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12 December 2020

Role of extracellular signal regulated kinase 5 in neuronal survival.

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12 December 2020

Activation of cyclin D1 expression by the ERK5 cascade.

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12 December 2020

Characterization of a neurotrophin signaling mechanism that mediates neuron survival in a temporally specific pattern.

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12 December 2020

BMK1 mediates growth factor-induced cell proliferation through direct cellular activation of serum and glucocorticoid-inducible kinase

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12 December 2020

MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway

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12 December 2020

Isolation of MEK5 and differential expression of alternatively spliced forms

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12 December 2020

Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain

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12 December 2020

Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis

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12 December 2020

10.1007/S00109-004-0602-8

Identifiers

DOI

1 reference

PubMed ID

15517128

Dimensions Publication ID

1 August 2017

0 references

1 reference

PubMed ID

15517128