Synaptic protection in the brain of WldS mice occurs independently of age but is sensitive to gene-dose (Q34362152)

1 August 2017

title

Synaptic protection in the brain of WldS mice occurs independently of age but is sensitive to gene-dose (English)

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1 August 2017

Thomas M Wishart

2

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Thomas H. Gillingwater

object named as

Thomas H Gillingwater

series ordinal

4

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author name string

Ann K Wright

series ordinal

1

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1 August 2017

Cali A Ingham

series ordinal

3

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1 August 2017

language of work or name

English

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publication date

29 November 2010

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1 August 2017

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1 August 2017

volume

5

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1 August 2017

issue

11

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1 August 2017

page(s)

e15108

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Creative Commons Attribution 4.0 International

1 August 2017

copyright license

start time

29 November 2010

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Wallerian degeneration, wld(s), and nmnat

1 reference

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Expression of the neuroprotective slow Wallerian degeneration (WldS) gene in non-neuronal tissues

6 July 2018

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Degenerating synaptic boutons in prion disease: microglia activation without synaptic stripping

6 July 2018

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Molecular correlates of axonal and synaptic pathology in mouse models of Batten disease

6 July 2018

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Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo

6 July 2018

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Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration

6 July 2018

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Wld S protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice

6 July 2018

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Non-nuclear Wld(S) determines its neuroprotective efficacy for axons and synapses in vivo.

6 July 2018

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The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model

6 July 2018

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Palmitoyl protein thioesterase-1 deficiency impairs synaptic vesicle recycling at nerve terminals, contributing to neuropathology in humans and mice

6 July 2018

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Modified cell cycle status in a mouse model of altered neuronal vulnerability (slow Wallerian degeneration; Wlds).

6 July 2018

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Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress

6 July 2018

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Design of a novel quantitative PCR (QPCR)-based protocol for genotyping mice carrying the neuroprotective Wallerian degeneration slow (Wlds) gene.

6 July 2018

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Differential proteomics analysis of synaptic proteins identifies potential cellular targets and protein mediators of synaptic neuroprotection conferred by the slow Wallerian degeneration (Wlds) gene

6 July 2018

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Synaptic vulnerability in neurodegenerative disease

6 July 2018

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NAD(+) and axon degeneration revisited: Nmnat1 cannot substitute for Wld(S) to delay Wallerian degeneration

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993971

The neuroprotective WldS gene regulates expression of PTTG1 and erythroid differentiation regulator 1-like gene in mice and human cells

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993971

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

6 July 2018

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The relationship of neuromuscular synapse elimination to synaptic degeneration and pathology: insights from WldS and other mutant mice

6 July 2018

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Alzheimer's disease is a synaptic failure

6 July 2018

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Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene.

6 July 2018

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A Ufd2/D4Cole1e chimeric protein and overexpression of Rbp7 in the slow Wallerian degeneration (WldS) mouse

6 July 2018

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An 85-kb tandem triplication in the slow Wallerian degeneration (Wlds) mouse

6 July 2018

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A gene affecting Wallerian nerve degeneration maps distally on mouse chromosome 4

6 July 2018

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Monosynaptic cortical input and local axon collaterals of identified striatonigral neurons. A light and electron microscopic study using the golgi-peroxidase transport-degeneration procedure

6 July 2018

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The site of termination of afferent fibres in the caudate nucleus.

6 July 2018

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Robust synaptic plasticity of striatal cells following partial deafferentation.

6 July 2018

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Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy

6 July 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015108

Delayed synaptic degeneration in the CNS of Wlds mice after cortical lesion.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015108

Wlds-mediated protection of dopaminergic fibers in an animal model of Parkinson disease

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015108

Wld(S) mice are protected against the Parkinsonian mimetic MPTP.

21 January 2018

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Neuroprotection after transient global cerebral ischemia in Wld(s) mutant mice.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015108

The WldS protein protects against axonal degeneration: a model of gene therapy for peripheral neuropathy

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015108

A rat model of slow Wallerian degeneration (WldS) with improved preservation of neuromuscular synapses

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015108

The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015108

Axonal and neuromuscular synaptic phenotypes in Wld(S), SOD1(G93A) and ostes mutant mice identified by fiber-optic confocal microendoscopy.

21 January 2018

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Ultrastructural correlates of synapse withdrawal at axotomized neuromuscular junctions in mutant and transgenic mice expressing the Wld gene.

21 January 2018

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Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration.

21 January 2018

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WldS can delay Wallerian degeneration in mice when interaction with valosin-containing protein is weakened.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015108

SMN deficiency disrupts brain development in a mouse model of severe spinal muscular atrophy

21 January 2018

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Loss of translation elongation factor (eEF1A2) expression in vivo differentiates between Wallerian degeneration and dying-back neuronal pathology

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015108

Pre-symptomatic development of lower motor neuron connectivity in a mouse model of severe spinal muscular atrophy

21 January 2018

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The Wlds mutation delays robust loss of motor and sensory axons in a genetic model for myelin-related axonopathy.

21 January 2018

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Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve

27 October 2018

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12 December 2020

Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease

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12 December 2020

Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man

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12 December 2020

Synapse loss associated with abnormal PrP precedes neuronal degeneration in the scrapie-infected murine hippocampus

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12 December 2020

Prolonged axonal survival in transected nerves of C57BL/Ola mice is independent of age

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12 December 2020

Stable inheritance of an 85-kb triplication in C57BL/WldS mice

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12 December 2020

Age-dependent synapse withdrawal at axotomised neuromuscular junctions in Wld(s) mutant and Ube4b/Nmnat transgenic mice

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0015108

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DOI

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1 August 2017

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1 August 2017

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