Do mammalian cytochrome P450s show multiple ligand access pathways and ligand channelling? (Q34360317)

1 August 2017

Do mammalian cytochrome P450s show multiple ligand access pathways and ligand channelling? (English)

1 reference

1 August 2017

Peter J Winn

3

0 references

Rebecca C Wade

object named as

Rebecca C Wade

5

0 references

author name string

Karin Schleinkofer

1

1 reference

PubMed ID

16028306

1 August 2017

Sudarko

2

1 reference

PubMed ID

16028306

1 August 2017

Susanne K Lüdemann

4

1 reference

1 August 2017

1 June 2005

1 reference

1 August 2017

1 reference

1 August 2017

6

1 reference

1 August 2017

584-589

1 reference

1 August 2017

6

1 reference

A survey of active site access channels in cytochromes P450.

1 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369091

Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369091

Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helix

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369091

Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369091

Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369091

A rational approach to Re-engineer cytochrome P450 2B1 regioselectivity based on the crystal structure of cytochrome P450 2C5.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369091

Comparison of the dynamics of substrate access channels in three cytochrome P450s reveals different opening mechanisms and a novel functional role for a buried arginine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369091

Pivotal role of water in the mechanism of P450BM-3

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369091

How do substrates enter and products exit the buried active site of cytochrome P450cam? 1. Random expulsion molecular dynamics investigation of ligand access channels and mechanisms.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369091

Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369091

Engineering microsomal cytochrome P450 2C5 to be a soluble, monomeric enzyme. Mutations that alter aggregation, phospholipid dependence of catalysis, and membrane binding

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369091

P450s: structural similarities and functional differences.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369091

Essential dynamics of proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369091

A computational procedure for determining energetically favorable binding sites on biologically important macromolecules

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369091

An inhibitory monoclonal antibody binds in close proximity to a determinant for substrate binding in cytochrome P450IIC5

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369091

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

6 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOR.7400420

Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOR.7400420

Estriol bound and ligand-free structures of sterol 14alpha-demethylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOR.7400420

How do substrates enter and products exit the buried active site of cytochrome P450cam? 2. Steered molecular dynamics and adiabatic mapping of substrate pathways.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1369091

Binding of camphor to Pseudomonas putida cytochrome p450(cam): steady-state and picosecond time-resolved fluorescence studies

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16028306

12 December 2020

inferred from PubMed ID database lookup

Identification of rabbit microsomal cytochrome P-450 isozyme, form 1, as a hepatic progesterone 21-hydroxylase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16028306

12 December 2020

inferred from PubMed ID database lookup

Rabbit hepatic progesterone 21-hydroxylase exhibits a bimodal distribution of activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16028306

12 December 2020

inferred from PubMed ID database lookup

Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOR.7400420

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/SJ.EMBOR.7400420

1 reference

1 August 2017

1 reference

1 August 2017

1 reference

PubMed ID

16028306