A review of pharmacology of NCS-382, a putative antagonist of gamma-hydroxybutyric acid (GHB) receptor. (Q34360139)

1 August 2017

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title

A review of pharmacology of NCS-382, a putative antagonist of gamma-hydroxybutyric acid (GHB) receptor (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741708&resulttype=core&format=json

12 May 2020

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M Paola Castelli

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741708&resulttype=core&format=json

12 May 2020

Fabio Pibiri

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741708&resulttype=core&format=json

12 May 2020

Giovanni Carboni

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741708&resulttype=core&format=json

12 May 2020

A Paola Piras

series ordinal

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741708&resulttype=core&format=json

12 May 2020

publication date

1 January 2004

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CNS Neuroscience & Therapeutics

1 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741708&resulttype=core&format=json

12 May 2020

volume

10

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741708&resulttype=core&format=json

12 May 2020

issue

3

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12 May 2020

page(s)

243-260

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Roles of gamma-aminobutyric acidB (GABA B) and gamma-hydroxybutyric acid receptors in hippocampal long-term potentiation and pathogenesis of absence seizures.

12 May 2020

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2004.TB00025.X

Evaluation of the discriminative stimulus and reinforcing effects of gammahydroxybutyrate (GHB).

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2004.TB00025.X

Gamma-hydroxybutyric acid, unlike gamma-aminobutyric acid, does not stimulate Gi/Go proteins in rat brain membranes

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1527-3458.2004.TB00025.X

Reduction of blood ethanol levels by the gamma-hydroxybutyric acid receptor antagonist, NCS-382

21 January 2018

1 reference

12 December 2020

Gamma-hydroxybutyric acid: an endogenous neuromodulator with abuse potential?

1 reference

12 December 2020

Gamma-hydroxybutyrate increases gastric emptying in rats.

1 reference

12 December 2020

gamma-Hydroxybutyrate modulates synthesis and extracellular concentration of gamma-aminobutyric acid in discrete rat brain regions in vivo.

1 reference

12 December 2020

Gamma-Hydroxybutyrate inhibits excitatory postsynaptic potentials in rat hippocampal slices

1 reference

12 December 2020

Design and structure-activity relationship analysis of ligands of gamma-hydroxybutyric acid receptors

1 reference

12 December 2020

Quantitative autoradiographic distribution of γ-hydroxybutyric acid binding sites in human and monkey brain

1 reference

12 December 2020

Evidence for a G protein-coupled gamma-hydroxybutyric acid receptor

1 reference

12 December 2020

A bibliography of drug discrimination research, 1992-1994

1 reference

12 December 2020

gamma-Hydroxybutyrate modulation of glutamate levels in the hippocampus: an in vivo and in vitro study

1 reference

12 December 2020

Role of GABA(B) receptors in the sedative/hypnotic effect of gamma-hydroxybutyric acid

1 reference

12 December 2020

Binding characteristics of the gamma-hydroxybutyric acid receptor antagonist [(3)H](2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid in the rat brain

1 reference

12 December 2020

Effects of the putative antagonist NCS382 on the behavioral pharmacological actions of gammahydroxybutyrate in mice

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12 December 2020

Stereoselectivity of NCS-382 binding to gamma-hydroxybutyrate receptor in the rat brain.

1 reference

12 December 2020

GABA(B)-receptor mediation of the inhibitory effect of gamma-hydroxybutyric acid on intestinal motility in mice

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12 December 2020

Gamma-hydroxybutyrate reduces GABA(A)-mediated inhibitory postsynaptic potentials in the CA1 region of hippocampus

1 reference

12 December 2020

The role of GABAB receptors in the discriminative stimulus effects of gamma-hydroxybutyrate in rats: time course and antagonism studies

1 reference

12 December 2020

Quantitative autoradiographic analysis of the new radioligand [(3)H](2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid ([(3)H]NCS-382) at gamma-hydroxybutyric acid (GHB) binding sites in rat brain

1 reference

12 December 2020

Cloning and characterization of a rat brain receptor that binds the endogenous neuromodulator gamma-hydroxybutyrate (GHB).

1 reference

12 December 2020

Experimental absence seizures: potential role of gamma-hydroxybutyric acid and GABAB receptors

1 reference

12 December 2020

gamma-Hydroxybutyrate depresses monosynaptic excitatory and inhibitory postsynaptic potentials in rat hippocampal slices.

1 reference

12 December 2020

Selective gamma-hydroxybutyric acid receptor ligands increase extracellular glutamate in the hippocampus, but fail to activate G protein and to produce the sedative/hypnotic effect of gamma-hydroxybutyric acid.

1 reference

12 December 2020

Effects of γ-Hydroxybutyrate (GHB) on Schedule-Controlled Responding in Rats: Role of GHB and GABAB Receptors

1 reference

12 December 2020

Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice

1 reference

12 December 2020

Pathway-specific action of gamma-hydroxybutyric acid in sensory thalamus and its relevance to absence seizures.

1 reference

12 December 2020

Discriminative stimulus effects of gamma-hydroxybutyrate in pigeons: role of diazepam-sensitive and -insensitive GABA(A) and GABA(B) receptors

1 reference

12 December 2020

From the street to the brain: neurobiology of the recreational drug gamma-hydroxybutyric acid

1 reference

12 December 2020

Calcium antagonists isradipine and nimodipine suppress cocaine and morphine intravenous self-administration in drug-naive mice.

1 reference

12 December 2020

Anti-sedative and anti-cataleptic properties of NCS-382, a γ-hydroxybutyrate receptor antagonist

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12 December 2020

Extracellular events induced by gamma-hydroxybutyrate in striatum: a microdialysis study.

1 reference

12 December 2020

GABAB autoreceptors regulate the induction of LTP

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12 December 2020

Effect of gamma-crotonolactone in experimental models of generalized absence seizures.

1 reference

12 December 2020

Gamma-hydroxybutyric acid in alcohol preference, dependence and withdrawal.

1 reference

12 December 2020

A specific gamma-hydroxybutyrate receptor ligand possesses both antagonistic and anticonvulsant properties

1 reference

12 December 2020

Properties of γ-aminobutyric acid (GABA) receptor binding in rat brain synaptic membrane fractions

1 reference

12 December 2020

Gamma-hydroxybutyrate stimulation of the formation of cyclic GMP and inositol phosphates in rat hippocampal slices.

1 reference

12 December 2020

[3H](-)Baclofen: an improved ligand for GABAB sites

1 reference

12 December 2020

3'-5' cyclic-guanosine monophosphate increase in rat brain hippocampus after gamma-hydroxybutyrate administration. Prevention by valproate and naloxone.

1 reference

12 December 2020

Effects of gamma-hydroxybutyrate and gamma-butyrolactone derivates on spontaneous generalized non-convulsive seizures in the rat.

1 reference

12 December 2020

Gamma-hydroxybutyric acid binding sites in rat and human brain synaptosomal membranes

1 reference

12 December 2020

The stimulus properties of gamma-hydroxybutyrate.

1 reference

12 December 2020

High affinity binding sites for gamma-hydroxybutyric acid in rat brain.

1 reference

12 December 2020

Gamma-hydroxybutyrate promotes oscillatory activity of rat and cat thalamocortical neurons by a tonic GABAB, receptor-mediated hyperpolarization.

1 reference

12 December 2020

Effect of gamma-hydroxybutyrate and its antagonist NCS-382 on spontaneous cell firing in the prefrontal cortex of the rat.

1 reference

12 December 2020

Presynaptic gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acidB (GABAB) receptor-mediated release of GABA and glutamate (GLU) in rat thalamic ventrobasal nucleus (VB): a possible mechanism for the generation of absence-like seizures [...]

1 reference

12 December 2020

The ontogeny of [3H]gamma-hydroxybutyrate and [3H]GABAB binding sites: relation to the development of experimental absence seizures

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12 December 2020

Symmetrical generalization between the discriminative stimulus effects of gamma-hydroxybutyric acid and ethanol: occurrence within narrow dose ranges.

1 reference

12 December 2020

Blockade of the discriminative stimulus effects of gamma-hydroxybutyric acid (GHB) by the GHB receptor antagonist NCS-382.

1 reference

12 December 2020

Oral self-administration of gamma-hydroxybutyric acid in the rat.

1 reference

12 December 2020

Antiabsence seizure activity of specific GABAB and gamma-Hydroxybutyric acid receptor antagonists

1 reference

12 December 2020

Functional observational battery comparing effects of ethanol, 1,1,1-trichloroethane, ether, and flurothyl

1 reference

12 December 2020

Relation of the [3H] gamma-hydroxybutyric acid (GHB) binding site to the gamma-aminobutyric acidB (GABAB) receptor in rat brain

1 reference

12 December 2020

Effect of gamma-hydroxybutyrate on central dopamine release in vivo. A microdialysis study in awake and anesthetized animals

1 reference

12 December 2020

Does gamma-hydroxybutyrate inhibit or stimulate central DA release?

1 reference

12 December 2020

Binding characteristics of gamma-hydroxybutyric acid as a weak but selective GABAB receptor agonist.

1 reference

12 December 2020

The gamma-hydroxybutyrate signalling system in brain: organization and functional implications.

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12 December 2020

gamma-Hydroxybutyrate conversion into GABA induces displacement of GABAB binding that is blocked by valproate and ethosuximide.

1 reference

12 December 2020

Rewarding properties of gamma-hydroxybutyric acid: an evaluation through place preference paradigm.

1 reference

12 December 2020

Gammahydroxybutyrate (GHB) receptor ligand effects on evoked synaptic field potentials in CA1 of the rat hippocampal slice

1 reference

12 December 2020

Inhibition of firing rate and changes in the firing pattern of nigral dopamine neurons by gamma-hydroxybutyric acid (GHBA) are specifically induced by activation of GABA(B) receptors.

1 reference

12 December 2020

Neurochemical and electrophysiological evidence for the existence of a functional gamma-hydroxybutyrate system in NCB-20 neurons

1 reference

12 December 2020

Gamma-hydroxybutyrate is a GABAB receptor agonist that increases a potassium conductance in rat ventral tegmental dopamine neurons.

1 reference

12 December 2020

Gamma-hydroxybutyric acid reducing effect on ethanol intake: evidence in favour of a substitution mechanism

1 reference

12 December 2020

Intravenous self-administration of gamma-hydroxybutyric acid in drug-naive mice.

1 reference

12 December 2020

10.1111/J.1527-3458.2004.TB00025.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741708&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741708&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6741708&resulttype=core&format=json