Caspase-dependent, geldanamycin-enhanced cleavage of co-chaperone p23 in leukemic apoptosis (Q34358774)

1 August 2017

Caspase-dependent, geldanamycin-enhanced cleavage of co-chaperone p23 in leukemic apoptosis (English)

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1 August 2017

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Gjertsen BT

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1 August 2017

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Døskeland SO

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1 August 2017

Gausdal G

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1 August 2017

Fladmark KE

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1 August 2017

Demol H

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1 August 2017

Vandekerckhove J

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1 December 2004

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1989-1996

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2403508

1 August 2017

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The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation

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Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

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Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

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The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR

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Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis

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Properties of the co-chaperone protein p23 erroneously attributed to ALG-2 (apoptosis-linked gene 2).

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An unstructured C-terminal region of the Hsp90 co-chaperone p23 is important for its chaperone function

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Regulation of cytosolic prostaglandin E synthase by phosphorylation

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Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

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Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases

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p23, a simple protein with complex activities

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Genetic dissection of p23, an Hsp90 cochaperone, reveals a distinct surface involved in estrogen receptor signaling

21 January 2018

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Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis

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Regulation of cytosolic prostaglandin E2 synthase by 90-kDa heat shock protein

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A novel, extraneuronal role for cyclin-dependent protein kinase 5 (CDK5): modulation of cAMP-induced apoptosis in rat leukemia cells

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The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

21 January 2018

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Stoichiometry, abundance, and functional significance of the hsp90/hsp70-based multiprotein chaperone machinery in reticulocyte lysate.

21 January 2018

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The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy

21 January 2018

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Hsp90 as an anti-cancer target

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7 January 2021

Chaperone function of Hsp90-associated proteins

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7 January 2021

Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23

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7 January 2021

Analysis of heat-shock protein expression in myeloid leukaemia cells by flow cytometry

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7 January 2021

p41 as a possible marker for cell death is generated by caspase cleavage of p42/SETbeta in irradiated MOLT-4 cells

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7 January 2021

The 23-kDa acidic protein in reticulocyte lysate is the weakly bound component of the hsp foldosome that is required for assembly of the glucocorticoid receptor into a functional heterocomplex with hsp90

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7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2403508

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Dimensions Publication ID

1 August 2017

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