Bioactivation mechanism of the cytotoxic and nephrotoxic S-conjugate S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine (Q34357210)

1 August 2017

title

Bioactivation mechanism of the cytotoxic and nephrotoxic S-conjugate S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine (English)

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1 August 2017

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W Dekant

1

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1 August 2017

L H Lash

series ordinal

2

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1 August 2017

M W Anders

series ordinal

3

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1 August 2017

language of work or name

English

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publication date

1 November 1987

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Proceedings of the National Academy of Sciences of the United States of America

1 August 2017

published in

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1 August 2017

volume

84

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1 August 2017

issue

21

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1 August 2017

page(s)

7443-7447

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The metabolic effects of dichloroacetate

1 August 2017

cites work

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6 July 2018

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Fluoride-induced diuresis: renal-tissue solute concentrations, functional, hemodynamic, and histologic correlates in the rat.

6 July 2018

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Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids

6 July 2018

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Nephrotoxicity of S-(2-chloro-1,1,2-trifluoroethyl)glutathione and S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine, the glutathione and cysteine conjugates of chlorotrifluoroethene

6 July 2018

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A purified cysteine conjugate beta-lyase from rat kidney cytosol. Requirement for an alpha-keto acid or an amino acid oxidase for activity and identity with soluble glutamine transaminase K.

6 July 2018

1 reference

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Identification of S-1,2-dichlorovinyl-N-acetyl-cysteine as a urinary metabolite of trichloroethylene: a possible explanation for its nephrocarcinogenicity in male rats.

6 July 2018

1 reference

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Metabolism of S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine to hydrogen sulfide and the role of hydrogen sulfide in S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine-induced mitochondrial toxicity

6 July 2018

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S-[2-(N7-guanyl)ethyl]glutathione, the major DNA adduct formed from 1,2-dibromoethane.

6 July 2018

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Bacterial beta-lyase mediated cleavage and mutagenicity of cysteine conjugates derived from the nephrocarcinogenic alkenes trichloroethylene, tetrachloroethylene and hexachlorobutadiene

6 July 2018

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Cellular effects of reactive intermediates: nephrotoxicity of S-conjugates of amino acids

6 July 2018

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Purification of soluble and mitochondrial glutamine transaminase K from rat kidney. Use of a sensitive assay involving transamination between L-phenylalanine and alpha-keto-gamma-methiolbutyrate

6 July 2018

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The mutagenic effect of 1,2-dichloroethane on Salmonella typhimurium I. Activation through conjugation with glutathion in vitro

6 July 2018

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Identification of S-1,2,2-trichlorovinyl-N-acetylcysteine as a urinary metabolite of tetrachloroethylene: bioactivation through glutathione conjugation as a possible explanation of its nephrocarcinogenicity

6 July 2018

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12 December 2020

Effects of inhaled chlorotrifluoroethylene and hexafluoropropene on the rat kidney

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12 December 2020

Assay of cysteine conjugate beta-lyase activity with S-(2-benzothiazolyl)cysteine as the substrate

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12 December 2020

Renal processing of glutathione conjugates. Role in nephrotoxicity

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12 December 2020

Enzymatic reaction of chlorotrifluoroethene with glutathione: 19F NMR evidence for stereochemical control of the reaction

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12 December 2020

The transamination of L-cystathionine, L-cystine and related compounds by a bovine kidney transaminase

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12 December 2020

Alpha-ketoacids stimulate rat renal cysteine conjugate beta-lyase activity and potentiate the cytotoxicity of S-(1,2-dichlorovinyl)-L-cysteine

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12 December 2020

Identifiers

DOI

10.1073/PNAS.84.21.7443

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1 August 2017

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1 August 2017

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