Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity (Q34354902)

1 August 2017

Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity. (English)

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1 August 2017

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Marta Filizola

9

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author name string

Ivone Gomes

1

1 reference

1 August 2017

Wakako Fujita

2

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1 August 2017

Achla Gupta

3

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1 August 2017

S Adrian Saldanha

4

1 reference

1 August 2017

Ana Negri

5

1 reference

1 August 2017

Christine E Pinello

6

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1 August 2017

Christina Eberhart

7

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1 August 2017

Edward Roberts

8

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1 August 2017

Peter Hodder

10

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1 August 2017

Lakshmi A Devi

11

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1 August 2017

language of work or name

English

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publication date

1 July 2013

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Proceedings of the National Academy of Sciences of the United States of America

1 August 2017

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1 August 2017

110

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1 August 2017

29

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1 August 2017

12072-12077

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The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors

1 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3718106

Standard opioid agonists activate heteromeric opioid receptors: evidence for morphine and [d-Ala(2)-MePhe(4)-Glyol(5)]enkephalin as selective μ-δ agonists

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3718106

Identification of a dual δ OR antagonist/μ OR agonist as a potential therapeutic for diarrhea-predominant Irritable Bowel Syndrome (IBS-d).

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3718106

Modulation of gastrointestinal function by MuDelta, a mixed µ opioid receptor agonist/ µ opioid receptor antagonist

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3718106

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3718106

Chronic morphine alters the presynaptic protein profile: identification of novel molecular targets using proteomics and network analysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3718106

G protein-coupled receptor heteromerization: a role in allosteric modulation of ligand binding

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3718106

jCompoundMapper: An open source Java library and command-line tool for chemical fingerprints

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3718106

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3718106

Increased abundance of opioid receptor heteromers after chronic morphine administration

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3718106

Augmentation of spinal morphine analgesia and inhibition of tolerance by low doses of mu- and delta-opioid receptor antagonists

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3718106

Receptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimers

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3718106

Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3718106

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3718106

A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3718106

Opioid Receptor Oligomerization: Detection and Functional Characterization of Interacting Receptors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3718106

Heterodimerization of mu and delta opioid receptors: A role in opiate synergy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3718106

Enhanced morphine analgesia in mice lacking beta-arrestin 2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3718106

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3718106

Retention of supraspinal delta-like analgesia and loss of morphine tolerance in delta opioid receptor knockout mice

6 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1222044110

Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1222044110

Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1222044110

Automatic generation of 3D-atomic coordinates for organic molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1222044110

Using extended-connectivity fingerprints with Laplacian-modified Bayesian analysis in high-throughput screening follow-up

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1222044110

Intrathecal morphine in mice: a new technique

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23818586

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1222044110

1 reference

1 August 2017

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1 reference

1 August 2017

1 reference