Discovery of a novel noniminosugar acid α glucosidase chaperone series (Q34352720)

1 August 2017

title

Discovery of a novel noniminosugar acid α glucosidase chaperone series (English)

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1 August 2017

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7

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8

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Leslie Matalonga

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Antonia Ribes

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Antonia Ribes

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Anton Simeonov

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object named as

Anton Simeonov

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Juan J Marugan

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Ehud Goldin

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3

Omid Motabar

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2

Wendy Westbroek

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Arash Velayati

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1 August 2017

Jingbo Xiao

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Wendy A Lea

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1 August 2017

Xin Hu

5

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Ann Marie Gustafson

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Ellen Sidransky

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Ke Liu

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Rafael J Tamargo

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Marc Ferrer

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language of work or name

English

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publication date

17 August 2012

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Journal of Medicinal Chemistry

1 August 2017

published in

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volume

55

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1 August 2017

issue

17

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1 August 2017

page(s)

7546-7559

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Molecular interaction studies using microscale thermophoresis

1 August 2017

cites work

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Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity

6 July 2018

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Pharmacological small molecules for the treatment of lysosomal storage disorders.

6 July 2018

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Effects of pH and Iminosugar Pharmacological Chaperones on Lysosomal Glycosidase Structure and Stability

6 July 2018

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A new resorufin-based alpha-glucosidase assay for high-throughput screening

6 July 2018

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A counterintuitive approach to treat enzyme deficiencies: use of enzyme inhibitors for restoring mutant enzyme activity

6 July 2018

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Active-site-specific chaperone therapy for Fabry disease. Yin and Yang of enzyme inhibitors

6 July 2018

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The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

6 July 2018

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Synthesis and antiproliferative activities of isoindigo and azaisoindigo derivatives.

6 July 2018

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Pharmacological enhancement of mutated alpha-glucosidase activity in fibroblasts from patients with Pompe disease

6 July 2018

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Recombinant human acid [alpha]-glucosidase: major clinical benefits in infantile-onset Pompe disease

6 July 2018

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New therapeutic options for lysosomal storage disorders: enzyme replacement, small molecules and gene therapy

6 July 2018

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Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

6 July 2018

1 reference

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Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

6 July 2018

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NIH Molecular Libraries Initiative

6 July 2018

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Glycosidase inhibitors: update and perspectives on practical use.

6 July 2018

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Therapeutic applications of imino sugars in lysosomal storage disorders

6 July 2018

1 reference

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Acid alpha-glucosidase deficiency (glycogenosis type II, Pompe disease).

6 July 2018

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Allosteric activation of acid alpha-glucosidase by the human papillomavirus E7 protein

6 July 2018

1 reference

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Clinical diversity in glycogenosis type II. Biosynthesis and in situ localization of acid alpha-glucosidase in mutant fibroblasts

6 July 2018

1 reference

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The pharmacological chaperone 1-deoxynojirimycin increases the activity and lysosomal trafficking of multiple mutant forms of acid alpha-glucosidase

6 July 2018

1 reference

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Binding parameters and thermodynamics of the interaction of imino sugars with a recombinant human acid alpha-glucosidase (alglucosidase alfa): insight into the complex formation mechanism

27 October 2018

1 reference

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Glycogenosis type II: identification and expression of three novel mutations in the acid alpha-glucosidase gene causing the infantile form of the disease.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448374

Twenty-two novel mutations in the lysosomal ?-glucosidase gene (GAA) underscore the genotype-phenotype correlation in glycogen storage disease type II

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3448374

Carrier frequency for glycogen storage disease type II in New York and estimates of affected individuals born with the disease

27 October 2018

1 reference

12 December 2020

Chemical chaperones improve transport and enhance stability of mutant alpha-glucosidases in glycogen storage disease type II

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12 December 2020

Defects in synthesis, phosphorylation, and maturation of acid alpha-glucosidase in glycogenosis type II

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12 December 2020

Characterization of human saposins by NMR spectroscopy

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12 December 2020

Identifiers

DOI

10.1021/JM3005543

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1 August 2017

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1 August 2017

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