The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing. (Q34341876)

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English	The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing.	scientific article

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29 February 2020

The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing (English)

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alternative mRNA splicing, via spliceosome

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John S. Mattick

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Darya P Vanichkina

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Murray J Cairns

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Ernst Wolvetang

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J A Briggs

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E M Poth

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N J Beveridge

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V S Ratnu

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S P Nayler

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K Nones

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J Hu

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T W Bredy

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S Nakagawa

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F Rigo

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R J Taft

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S Blackshaw

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30 April 2013

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Molecular Psychiatry

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486-494

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29 February 2020

https://scigraph.springernature.com/pub.10.1038/mp.2013.45

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Exome sequencing supports a de novo mutational paradigm for schizophrenia.

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Aberrant regulation of alternative pre-mRNA splicing in schizophrenia

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DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms

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Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia

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Competition between a noncoding exon and introns: Gomafu contains tandem UACUAAC repeats and associates with splicing factor-1.

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RNA maps reveal new RNA classes and a possible function for pervasive transcription

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The mRNA-like noncoding RNA Gomafu constitutes a novel nuclear domain in a subset of neurons.

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Transcriptome sequencing revealed significant alteration of cortical promoter usage and splicing in schizophrenia.

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Identifiers

10.1038/MP.2013.45

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29 February 2020

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29 February 2020

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