Blockade of nociceptin/orphanin FQ receptor signaling in rat substantia nigra pars reticulata stimulates nigrostriatal dopaminergic transmission and motor behavior. (Q34337014)

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English	Blockade of nociceptin/orphanin FQ receptor signaling in rat substantia nigra pars reticulata stimulates nigrostriatal dopaminergic transmission and motor behavior.	scientific article

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1 August 2017

Blockade of nociceptin/orphanin FQ receptor signaling in rat substantia nigra pars reticulata stimulates nigrostriatal dopaminergic transmission and motor behavior (English)

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12 May 2020

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1 reference

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substantia nigra

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1

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12 May 2020

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12 May 2020

Severo Salvadori

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12 May 2020

Nicola B. Mercuri

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12 May 2020

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Flora Mela

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Carlo Veronesi

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12 May 2020

Anna Rizzi

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12 May 2020

Gianfranco Franchi

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12 May 2020

Lorenzo Beani

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12 May 2020

Clementina Bianchi

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12 May 2020

Michele Morari

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12 May 2020

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publication date

1 July 2004

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1 August 2017

Journal of Neuroscience

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12 May 2020

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12 May 2020

6659-6666

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12 May 2020

GABA(A) and GABA(B) antagonists differentially affect the firing pattern of substantia nigra dopaminergic neurons in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Orphanin FQ/nociceptin modulation of mesolimbic dopamine transmission determined by microdialysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Orphanin FQ reduces morphine-induced dopamine release in the nucleus accumbens: a microdialysis study in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pertussis toxin lesions of the rat substantia nigra block the inhibitory effects of the gamma-hydroxybutyrate agent, S(-)HA-966 without affecting the basal firing properties of dopamine neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl-1, 3-dihydro-2H-benzimidazol-2-one (J-113397)

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A potent and highly selective nonpeptidyl nociceptin/orphanin FQ receptor (ORL1) antagonist: J-113397.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacology of nociceptin and its receptor: a novel therapeutic target

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological characterization of the nociceptin receptor mediating hyperphagia: identification of a selective antagonist.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Further Studies on Nociceptin-Related Peptides: Discovery of a New Chemical Template with Antagonist Activity on the Nociceptin Receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of an antisense oligonucleotide to pronociceptin and long-term prevention of morphine actions by nociceptin

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nociceptin differentially affects morphine-induced dopamine release from the nucleus accumbens and nucleus caudate in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced spinal nociceptin receptor expression develops morphine tolerance and dependence.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the locomotor activity-inhibiting effect of nociceptin/orphanin FQ in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Orphanin FQ/nociceptin attenuates motor stimulation and changes in nucleus accumbens extracellular dopamine induced by cocaine in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new synthetic approach to 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-benzimidazol-2-one(J-113397), the first non-peptide ORL-1 receptor antagonist..

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular and behavioral pharmacology of the orphanin FQ/nociceptin peptide and receptor family

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory action of nociceptin/orphanin FQ on functionally different thalamic neurons in urethane-anaesthetized rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nociceptin receptor antagonists display antidepressant-like properties in the mouse forced swimming test

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nociceptin/orphanin FQ and opioid receptor-like receptor mRNA expression in dopamine systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Nphe1,Arg14,Lys15]nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nociceptin/orphanin FQ receptors modulate glutamate extracellular levels in the substantia nigra pars reticulata. A microdialysis study in the awake freely moving rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Actions of orphanin FQ/nociceptin on rat ventral tegmental area neurons in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat ventral midbrain dopamine neurons express the orphanin FQ/nociceptin receptor ORL-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of the nociceptin receptor does not affect acute or chronic nociception in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heroin-induced locomotion and mesolimbic dopamine release is unchanged in mice lacking the ORL.1 receptor gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Striatal dopamine-NMDA receptor interactions in the modulation of glutamate release in the substantia nigra pars reticulata in vivo: opposite role for D1 and D2 receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of striatal and retinal dopamine release via nociceptin/orphanin FQ receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological profiles of presynaptic nociceptin/orphanin FQ receptors modulating 5-hydroxytryptamine and noradrenaline release in the rat neocortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatodendritic dopamine release in rat substantia nigra influences motor performance on the accelerating rod.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of task parameters on rotarod performance and sensitivity to ethanol in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of nociceptin/orphanin FQ-NOP receptor signalling produces antidepressant-like effects: pharmacological and genetic evidences from the mouse forced swimming test.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptide and nonpeptide ligands for the nociceptin/orphanin FQ receptor ORL1: research tools and potential therapeutic agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modification of Nociception and Morphine Tolerance by the Selective Opiate Receptor-Like Orphan Receptor Antagonist (–)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111)

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tonic inhibition by orphanin FQ/nociceptin of noradrenaline neurotransmission in the amygdala

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exogenous, but not endogenous nociceptin modulates mesolimbic dopamine release in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of glycine on neurons in the rat substantia nigra zona compacta: in vitro electrophysiological study

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine acts on D2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rotational behavior mediated by dopaminergic and nondopaminergic mechanisms after intranigral microinjection of specific mu, delta and kappa opioid agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Non-dopaminergic mechanisms in the turning behavior evoked by intranigral opiates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve conduction, tactile sensibility, and the electromyogram after suture or compression of peripheral nerve: a longitudinal study in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circling behavior and stereotypy induced by intranigral opiate microinjections

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The actions of antipsychotic drugs on dopamine receptors in the rat substantia nigra

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disinhibition of nigral GABA output neurons mediates muscular rigidity elicited by striatal opioid receptor stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of the substantia nigra in motility of the rat. Muscular rigidity, body asymmetry and catalepsy after injection of morphine into the nigra

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Properties of the hyperpolarization-activated cation current Ih in rat midbrain dopaminergic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of haloperidol on the activity and membrane physiology of substantia nigra dopamine neurons recorded in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracerebroventricular orphanin FQ/nociceptin suppresses dopamine release in the nucleus accumbens of anaesthetized rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rats rapidly develop tolerance to the locomotor-inhibiting effects of the novel neuropeptide orphanin FQ.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic morphine-induced Fos protein in the rat striatum and nucleus accumbens is regulated by mu opioid receptors in the substantia nigra and ventral tegmental area

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An automated rotarod method for quantitative drug-free evaluation of overall motor deficits in rat models of parkinsonism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of antinociception induced by naloxone benzoylhydrazone in nociceptin receptor-knockout mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ontogeny of the diurnal rhythm of tuberoinfundibular dopaminergic neuronal activity in peripubertal female rats: possible involvement of cholinergic and opioidergic systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/15282268

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.0987-04.2004

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729727&resulttype=core&format=json

12 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729727&resulttype=core&format=json

12 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729727&resulttype=core&format=json

12 May 2020

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