The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response. (Q34325516)

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7 February 2020

title

The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response (English)

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7 February 2020

0 references

3

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7 February 2020

Mariane B Melo

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7 February 2020

Jeroen P Saeij

10

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Eric Spooner

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7 February 2020

author name string

Wendy Niedelman

1

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7 February 2020

Daniel A Gold

2

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7 February 2020

Joris K Sprokholt

4

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7 February 2020

Daniel Lim

5

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7 February 2020

Ailan Farid Arenas

6

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7 February 2020

Michael B Yaffe

9

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7 February 2020

publication date

28 June 2012

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7 February 2020

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7 February 2020

volume

8

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7 February 2020

issue

6

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7 February 2020

page(s)

e1002784

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Creative Commons Attribution 4.0 International

7 February 2020

copyright license

start time

28 June 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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ImageQuant

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11 June 2022

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CZ Software Mentions: A large dataset of software mentions in the biomedical literature

cites work

Globally diverse Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineages

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A monomorphic haplotype of chromosome Ia is associated with widespread success in clonal and nonclonal populations of Toxoplasma gondii

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A Conserved Non-canonical Motif in the Pseudoactive Site of the ROP5 Pseudokinase Domain Mediates Its Effect on Toxoplasma Virulence

6 July 2018

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ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18.

6 July 2018

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Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases

6 July 2018

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Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence

6 July 2018

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6 July 2018

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Genetic analyses of atypical Toxoplasma gondii strains reveal a fourth clonal lineage in North America

6 July 2018

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Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii

6 July 2018

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Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein.

6 July 2018

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Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence

6 July 2018

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Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria

6 July 2018

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NALP1 influences susceptibility to human congenital toxoplasmosis, proinflammatory cytokine response, and fate of Toxoplasma gondii-infected monocytic cells.

6 July 2018

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Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6.

6 July 2018

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P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages.

6 July 2018

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Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole

6 July 2018

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A helical membrane-binding domain targets the Toxoplasma ROP2 family to the parasitophorous vacuole

6 July 2018

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Sensitive and accurate detection of copy number variants using read depth of coverage

6 July 2018

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Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria

6 July 2018

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Selection at a single locus leads to widespread expansion of Toxoplasma gondii lineages that are virulent in mice

6 July 2018

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Virulent Toxoplasma gondii evade immunity-related GTPase-mediated parasite vacuole disruption within primed macrophages

6 July 2018

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Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death

6 July 2018

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Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens

6 July 2018

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Extending genome-wide association studies to copy-number variation

6 July 2018

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Mapping short DNA sequencing reads and calling variants using mapping quality scores

6 July 2018

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Ocular sequelae of congenital toxoplasmosis in Brazil compared with Europe

6 July 2018

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Recent transcontinental sweep of Toxoplasma gondii driven by a single monomorphic chromosome

6 July 2018

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Bradyzoite-specific surface antigen SRS9 plays a role in maintaining Toxoplasma gondii persistence in the brain and in host control of parasite replication in the intestine

6 July 2018

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Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue

6 July 2018

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Polymorphic secreted kinases are key virulence factors in toxoplasmosis

6 July 2018

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A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii

6 July 2018

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Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages

6 July 2018

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Emerging roles of pseudokinases

6 July 2018

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Globalization and the population structure of Toxoplasma gondii

6 July 2018

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Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii

6 July 2018

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Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases.

6 July 2018

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The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage

6 July 2018

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Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

6 July 2018

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Bioluminescence imaging of Toxoplasma gondii infection in living mice reveals dramatic differences between strains.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3386190

The function of gamma interferon-inducible GTP-binding protein IGTP in host resistance to Toxoplasma gondii is Stat1 dependent and requires expression in both hematopoietic and nonhematopoietic cellular compartments

6 July 2018

1 reference

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Population biology of Toxoplasma gondii and its relevance to human infection: do different strains cause different disease?

6 July 2018

1 reference

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Biogenesis of nanotubular network in Toxoplasma parasitophorous vacuole induced by parasite proteins

6 July 2018

1 reference

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Severe acute disseminated toxoplasmosis acquired by an immunocompetent patient in French Guiana

6 July 2018

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6 July 2018

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Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection

6 July 2018

1 reference

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Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP

6 July 2018

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Targeted disruption of the GRA2 locus in Toxoplasma gondii decreases acute virulence in mice

6 July 2018

1 reference

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Pathogenicity and infectivity of Toxoplasma gondii oocysts for rats.

6 July 2018

1 reference

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Antiparasitic and antiproliferative effects of indoleamine 2,3-dioxygenase enzyme expression in human fibroblasts

6 July 2018

1 reference

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Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan

6 July 2018

1 reference

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Molecular analysis of the gene encoding the major surface antigen of Toxoplasma gondii.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3386190

Virulent strains of Toxoplasma gondii comprise a single clonal lineage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3386190

Unusual abundance of atypical strains associated with human ocular toxoplasmosis.

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002784

Toxoplasma gondii: inconsistent dissemination patterns following oral infection in mice.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002784

Toxoplasma gondii comprises three clonal lineages: correlation of parasite genotype with human disease

21 January 2018

1 reference

12 December 2020

In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection

1 reference

12 December 2020

Interferon-gamma-activated primary enterocytes inhibit Toxoplasma gondii replication: a role for intracellular iron.

1 reference

12 December 2020

Inverted topology of the Toxoplasma gondii ROP5 rhoptry protein provides new insights into the association of the ROP2 protein family with the parasitophorous vacuole membrane

1 reference

12 December 2020

Population structure and mouse-virulence of Toxoplasma gondii in Brazil

1 reference

12 December 2020

10.1371/JOURNAL.PPAT.1002784

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22761577%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22761577%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22761577%20AND%20SRC:MED&resulttype=core&format=json