Tumor protein p53 (TP53) testing and Li-Fraumeni syndrome : current status of clinical applications and future directions (Q34324683)

1 August 2017

1 reference

title

Tumor protein p53 (TP53) testing and Li-Fraumeni syndrome : current status of clinical applications and future directions (English)

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1 August 2017

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April D Sorrell

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1 August 2017

Carin R Espenschied

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2

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1 August 2017

Julie O Culver

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3

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1 August 2017

Jeffrey N Weitzel

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4

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1 August 2017

1 February 2013

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Molecular Diagnosis and Therapy

1 August 2017

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1 August 2017

17

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1 August 2017

31-47

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1 August 2017

1

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https://scigraph.springernature.com/pub.10.1007/s40291-013-0020-0

1 August 2017

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Early onset HER2-positive breast cancer is associated with germline TP53 mutations

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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A novel HER2-positive breast cancer phenotype arising from germline TP53 mutations.

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Tumor protein 53 mutations and inherited cancer: beyond Li-Fraumeni syndrome.

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Li-Fraumeni syndrome: the genetics and treatment considerations for the sarcoma and associated neoplasms

6 July 2018

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Association of the germline TP53 R337H mutation with breast cancer in southern Brazil

6 July 2018

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Excessive genomic DNA copy number variation in the Li-Fraumeni cancer predisposition syndrome

6 July 2018

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TP53 status and response to chemotherapy in breast cancer

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography

6 July 2018

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Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

6 July 2018

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

6 July 2018

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Restoration of p53 function leads to tumour regression in vivo

6 July 2018

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6 July 2018

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The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer

6 July 2018

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Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition

6 July 2018

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6 July 2018

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An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma

6 July 2018

1 reference

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Sensitivity and predictive value of criteria for p53 germline mutation screening

6 July 2018

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Patterns of p53 G-->T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke

6 July 2018

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Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.

6 July 2018

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P53 germline mutations in childhood cancers and cancer risk for carrier individuals

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627545

Are there low-penetrance TP53 Alleles? evidence from childhood adrenocortical tumors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627545

Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma.

6 July 2018

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Multiple primary cancers in families with Li-Fraumeni syndrome

6 July 2018

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Li-Fraumeni syndrome--a molecular and clinical review

6 July 2018

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6 July 2018

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Germline mutations in the TP53 gene

6 July 2018

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Tumor spectrum analysis in p53-mutant mice

6 July 2018

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The 53,000-dalton cellular protein and its role in transformation

6 July 2018

1 reference

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Detection of a common feature in several human tumor cell lines--a 53,000-dalton protein

6 July 2018

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Rhabdomyosarcoma in children: epidemiologic study and identification of a familial cancer syndrome

6 July 2018

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Cancer in survivors of childhood soft tissue sarcoma and their relatives

6 July 2018

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A cancer family syndrome in twenty-four kindreds

6 July 2018

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p53 in chronic myelogenous leukemia. Study of mechanisms of differential expression

6 July 2018

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Increased expression of p53 protein in human leukemia cells

6 July 2018

1 reference

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Rearrangement of the p53 gene in human osteogenic sarcomas

6 July 2018

1 reference

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High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene

6 July 2018

1 reference

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Expression of the p53 oncogene in acute myeloblastic leukemia

6 July 2018

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Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

6 July 2018

1 reference

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Choroid plexus tumors in the breast cancer-sarcoma syndrome.

6 July 2018

1 reference

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p53 functions as a cell cycle control protein in osteosarcomas

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627545

Suppression of human colorectal carcinoma cell growth by wild-type p53

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627545

The p53 tumour suppressor gene

6 July 2018

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Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627545

Segregation analysis of cancer in families of childhood soft-tissue-sarcoma patients

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627545

Relationship Between Mammographic and Histological Risk Factors for Breast Cancer

6 July 2018

1 reference

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Cancer. p53, guardian of the genome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627545

Case-control study of factors associated with failure to detect breast cancer by mammography

6 July 2018

1 reference

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627545

The Li-Fraumeni syndrome: from clinical epidemiology to molecular genetics

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627545

Germline mutations in the p53 tumour suppressor gene: scientific, clinical and ethical challenges

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627545

Genetic and pathologic findings in a kindred with hereditary sarcoma, breast cancer, brain tumors, leukemia, lung, laryngeal, and adrenal cortical carcinoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627545

The SV40 a gene product is required for the production of a 54,000 MW cellular tumor antigen

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627545

Simian virus 40-transformed cells express new species of proteins precipitable by anti-simian virus 40 tumor serum

6 July 2018

1 reference

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Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

6 July 2018

1 reference

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Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse

6 July 2018

1 reference

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T antigen is bound to a host protein in SY40-transformed cells

6 July 2018

1 reference

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Beyond Li Fraumeni Syndrome: clinical characteristics of families with p53 germline mutations.

6 July 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Chest wall leiomyosarcoma after breast-conservative therapy for early-stage breast cancer in a young woman with Li-Fraumeni syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Universal poor survival in children with medulloblastoma harboring somatic TP53 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Low rate of TP53 germline mutations in breast cancer/sarcoma families not fulfilling classical criteria for Li-Fraumeni syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Choroid plexus tumors; management, outcome, and association with the Li-Fraumeni syndrome: the Children's Hospital Los Angeles (CHLA) experience, 1991-2010.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Detection of R337H, a germline TP53 mutation predisposing to multiple cancers, in asymptomatic women participating in a breast cancer screening program in Southern Brazil

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Highly prevalent TP53 mutation predisposing to many cancers in the Brazilian population: a case for newborn screening?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Penetrance of adrenocortical tumours associated with the germline TP53 R337H mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

The TP53 mutation, R337H, is associated with Li-Fraumeni and Li-Fraumeni-like syndromes in Brazilian families.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Prevalence of early onset colorectal cancer in 397 patients with classic Li-Fraumeni syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Routine TP53 testing for breast cancer under age 30: ready for prime time?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: a prospective observational study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Preimplantation genetic diagnosis for cancer predisposition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Psychological functioning in persons considering genetic counseling and testing for Li-Fraumeni syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Genetic testing in Li-Fraumeni syndrome: uptake and psychosocial consequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Distress in partners of individuals diagnosed with or at high risk of developing tumors due to rare hereditary cancer syndromes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Informing patients: translating the NCCN guidelines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

F18-fluorodeoxyglucose-positron emission tomography/computed tomography screening in Li-Fraumeni syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Younger age of cancer initiation is associated with shorter telomere length in Li-Fraumeni syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Heritability of mammographic density, a risk factor for breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Reduced mammographic density with use of a gonadotropin-releasing hormone agonist-based chemoprevention regimen in BRCA1 carriers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

TP53 alterations determine clinical subgroups and survival of patients with choroid plexus tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

PARP1 expression in pediatric central nervous system tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Results of first salvage therapy for patients refractory to a fludarabine regimen in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

The natural history of fludarabine-refractory chronic lymphocytic leukemia patients who fail alemtuzumab or have bulky lymphadenopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Cancer gene therapy steadily advances

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Time to first tumor progression as a predictor of efficacy of continued treatment with trastuzumab beyond progression in human epidermal growth factor receptor 2-positive metastatic breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Metformin use is associated with a decreased incidence of colorectal adenomas in diabetic patients with previous colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Women age < or = 35 years with primary breast carcinoma: disease features at presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

NCCN molecular testing white paper: effectiveness, efficiency, and reimbursement

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627545

Myelodysplastic syndromes arising in patients with germline TP53 mutation and Li-Fraumeni syndrome.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627545

New challenges for informed consent through whole genome array testing

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627545

Li-Fraumeni and related syndromes: correlation between tumor type, family structure, and TP53 genotype.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627545

Preimplantation diagnosis for p53 tumour suppressor gene mutations.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627545

Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627545

Founder effect for the highly prevalent R337H mutation of tumor suppressor p53 in Brazilian patients with adrenocortical tumors

28 October 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

An Inherited Mutation Outside the Highly Conserved DNA-Binding Domain of the p53 Tumor Suppressor Protein in Children and Adults with Sporadic Adrenocortical Tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

A Japanese patient with Li-Fraumeni syndrome who had nine primary malignancies associated with a germline mutation of the p53 tumor-suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

TP53 germline mutation testing in 180 families suspected of Li-Fraumeni syndrome: mutation detection rate and relative frequency of cancers in different familial phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Pharmacogenetic and Germline Prognostic Markers of Lung Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Screening for germ line TP53 mutations in breast cancer patients

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627545

28 October 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

TP53Germline Mutations in Adult Patients with Adrenocortical Carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40291-013-0020-0

Metformin use and improved response to therapy in esophageal adenocarcinoma

21 January 2018

1 reference

12 December 2020

An inherited mutation outside the highly conserved DNA-binding domain of the p53 tumor suppressor protein in children and adults with sporadic adrenocortical tumors

1 reference

12 December 2020

Phase I trial of an antisense oligonucleotide OL(1)p53 in hematologic malignancies

1 reference

12 December 2020

Identification of five new families strengthens the link between childhood choroid plexus carcinoma and germline TP53 mutations

1 reference

12 December 2020

Genetic background alters the spectrum of tumors that develop in p53-deficient mice

1 reference

12 December 2020

A germ line mutation in exon 5 of the p53 gene in an extended cancer family

1 reference

12 December 2020

High frequency of de novo mutations in Li-Fraumeni syndrome

1 reference

12 December 2020

A comparison of the efficacy and safety of oral and intravenous fludarabine in chronic lymphocytic leukemia in the LRF CLL4 trial

1 reference

12 December 2020

2009 Version of the Chompret Criteria for Li Fraumeni Syndrome

1 reference

12 December 2020

Preimplantation genetic diagnosis for cancer syndromes: a new challenge for preventive medicine

1 reference

12 December 2020

The cellular protein p53 in human tumours

1 reference

12 December 2020

Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer

1 reference

12 December 2020

Molecular basis of the Li-Fraumeni syndrome: an update from the French LFS families

1 reference

12 December 2020

Prenatal diagnosis in Li-Fraumeni syndrome

1 reference

12 December 2020

Multiple primary cutaneous melanomas in Li-Fraumeni syndrome

1 reference

12 December 2020

Ex vivo treatment of bone marrow with phosphorothioate oligonucleotide OL(1)p53 for autologous transplantation in acute myelogenous leukemia and myelodysplastic syndrome

1 reference

12 December 2020

NCCN panel calls for higher standards, better ways of translating molecular genetics into clinical practice

1 reference

12 December 2020

10.1007/S40291-013-0020-0

Identifiers

DOI

1 reference

Dimensions Publication ID

1 August 2017

0 references

1 reference

1 August 2017

1 reference