Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger (Q34321453)

1 August 2017

Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger (English)

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1 August 2017

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Matthew J Craner

1

1 reference

1 August 2017

Jia Newcombe

2

1 reference

1 August 2017

Joel A Black

3

1 reference

1 August 2017

Caroline Hartle

4

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1 August 2017

M Louise Cuzner

5

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1 August 2017

Stephen G Waxman

6

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1 August 2017

language of work or name

English

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publication date

17 May 2004

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Proceedings of the National Academy of Sciences of the United States of America

1 August 2017

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1 August 2017

101

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1 August 2017

8168-8173

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1 August 2017

21

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Distinct repriming and closed-state inactivation kinetics of Nav1.6 and Nav1.7 sodium channels in mouse spinal sensory neurons

1 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Molecular cloning, distribution and functional analysis of the NA(V)1.6. Voltage-gated sodium channel from human brain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Nomenclature of voltage-gated sodium channels

6 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

6 July 2018

https://api.crossref.org/works/10.1073%2FPNAS.0402765101

Potent analgesic effects of GDNF in neuropathic pain states.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapses

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Functional analysis of the mouse Scn8a sodium channel.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Disruption and reorganization of sodium channels in experimental allergic neuritis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Resistance to anoxic injury in the dorsal columns of adult rat spinal cord following demyelination.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Axonal transection in the lesions of multiple sclerosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Immunolocalization of the Na(+)-Ca2+ exchanger in mammalian myelinated axons.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

The axonal membrane protein Caspr, a homologue of neurexin IV, is a component of the septate-like paranodal junctions that assemble during myelination

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Axonal damage in acute multiple sclerosis lesions.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Mechanisms of secondary injury to spinal cord axons in vitro: role of Na+, Na(+)-K(+)-ATPase, the Na(+)-H+ exchanger, and the Na(+)-Ca2+ exchanger.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Noninactivating, tetrodotoxin-sensitive Na+ conductance in rat optic nerve axons.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Organization and research applications of the U.K. Multiple Sclerosis Society Tissue Bank.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

A rat brain Na+ channel alpha subunit with novel gating properties

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Sodium channels in single demyelinated mammalian axons.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Anoxic injury of mammalian central white matter: decreased susceptibility in myelin-deficient optic nerve

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Changed distribution of sodium channels along demyelinated axons

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Increase of sodium channels in demyelinated lesions of multiple sclerosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Increased numbers of sodium channels form along demyelinated axons

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Elevated expression of type II Na+ channels in hypomyelinated axons of shiverer mouse brain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Tertiary and quaternary local anesthetics protect CNS white matter from anoxic injury at concentrations that do not block excitability.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Density of sodium channels in mammalian myelinated nerve fibers and nature of the axonal membrane under the myelin sheath

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Abnormal sodium channel distribution in optic nerve axons in a model of inflammatory demyelination

6 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402765101

Nitric oxide toxicity in CNS white matter: an in vitro study using rat optic nerve

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402765101

Blockers of sodium and calcium entry protect axons from nitric oxide-mediated degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402765101

Phenytoin protects spinal cord axons and preserves axonal conduction and neurological function in a model of neuroinflammation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402765101

Axonal protection using flecainide in experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402765101

Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402765101

Dysregulation of axonal sodium channel isoforms after adult-onset chronic demyelination

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402765101

Co-localization of sodium channel Nav1.6 and the sodium-calcium exchanger at sites of axonal injury in the spinal cord in EAE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402765101

Sodium channel Na(v)1.6 is expressed along nonmyelinated axons and it contributes to conduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402765101

Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402765101

Conduction in myelinated, unmyelinated, and demyelinated fibers

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402765101

Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Type I and type II Na(+) channel alpha-subunit polypeptides exhibit distinct spatial and temporal patterning, and association with auxiliary subunits in rat brain.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Effects of the sodium channel blocker tetrodotoxin on acute white matter pathology after experimental contusive spinal cord injury.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Rescue of alpha-SNS sodium channel expression in small dorsal root ganglion neurons after axotomy by nerve growth factor in vivo.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Rat optic nerve: electrophysiological, pharmacological and anatomical studies during development.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Rat optic nerve: Electrophysiological, pharmacological and anatomical studies during development

28 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402765101

Genetic dysmyelination alters the molecular architecture of the nodal region

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=419575

Structural parts involved in activation and inactivation of the sodium channel

28 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0402765101

Axonal changes in chronic demyelinated cervical spinal cord plaques

21 January 2018

1 reference

12 December 2020

Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation

1 reference

12 December 2020

A single pulse of nerve growth factor triggers long-term neuronal excitability through sodium channel gene induction

1 reference

12 December 2020

Demyelinating diseases--new pathological insights, new therapeutic targets

1 reference

12 December 2020

Internodal conduction in undissected demyelinated nerve fibres

1 reference

12 December 2020

The internodal axon membrane: electrical excitability and continuous conduction in segmental demyelination

1 reference

12 December 2020

Reorganization of the Axon Membrane in Demyelinated Peripheral Nerve Fibers: Morphological Evidence

1 reference

12 December 2020

Differential subcellular localization of the RI and RII Na+ channel subtypes in central neurons

1 reference

12 December 2020

Characterization and distribution of phagocytic macrophages in multiple sclerosis plaques

1 reference

12 December 2020

Neurological disability correlates with spinal cord axonal loss and reduced N-acetyl aspartate in chronic multiple sclerosis patients

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0402765101

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1 August 2017

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1 August 2017

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