Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex (Q34314489)

1 August 2017

Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex (English)

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1 August 2017

Matthew C Franklin

1

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1 August 2017

Kendall D Carey

2

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1 August 2017

Felix F Vajdos

3

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1 August 2017

Daniel J Leahy

4

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1 August 2017

Abraham M de Vos

5

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1 August 2017

Mark X Sliwkowski

6

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1 August 2017

1 April 2004

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1 August 2017

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1 August 2017

5

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1 August 2017

317-328

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1 August 2017

4

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Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth

1 August 2017

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

ErbB-targeted therapeutic approaches in human cancer

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Humanization of an anti-p185HER2 antibody for human cancer therapy

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Development of herceptin

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Structure of the extracellular region of HER3 reveals an interdomain tether

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Neuregulins: functions, forms, and signaling strategies

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Extracellular domains drive homo- but not hetero-dimerization of erbB receptors

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Mechanism of action of erbB tyrosine kinase inhibitors

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

A model for the activation of the epidermal growth factor receptor kinase involvement of an asymmetric dimer?

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

The ErbB receptors and their role in cancer progression.

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Epidermal growth factor receptor: mechanisms of activation and signalling.

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Antigen binding thermodynamics and antiproliferative effects of chimeric and humanized anti-p185HER2 antibody Fab fragments

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

The Drosophila EGF receptor gene homolog: conservation of both hormone binding and kinase domains

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Targeting cyclooxygenase 2 and HER-2/neu pathways inhibits colorectal carcinoma growth

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Structural analysis of p185c-neu and epidermal growth factor receptor tyrosine kinases: oligomerization of kinase domains

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Refinement of macromolecular structures by the maximum-likelihood method

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

AMoRe: an automated package for molecular replacement

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

The ErbB signaling network: receptor heterodimerization in development and cancer

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Mammalian cell transient expression of tissue factor for the production of antigen

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

HER2 as a predictor of therapeutic response in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

The HER-2/neu oncogene in breast cancer: prognostic factor, predictive factor, and target for therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

A discrete three-amino acid segment (LVI) at the C-terminal end of kinase-impaired ErbB3 is required for transactivation of ErbB2.

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Cell signaling by receptor tyrosine kinases

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Evolutionary analysis of the ErbB receptor and ligand families

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Comprehensive functional maps of the antigen-binding site of an anti-ErbB2 antibody obtained with shotgun scanning mutagenesis

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

A Drosophila genomic sequence with homology to human epidermal growth factor receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

The relationship between the L1 and L2 domains of the insulin and epidermal growth factor receptors and leucine-rich repeat modules

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

Untangling the ErbB signalling network

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

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https://api.crossref.org/works/10.1016%2FS1535-6108%2804%2900083-2

7 January 2021

10.1016/S1535-6108(04)00083-2

Identifiers

DOI

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1 August 2017

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