Knockdown of the Drosophila fused in sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches. (Q34314477)

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English	Knockdown of the Drosophila fused in sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches.	scientific article

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5 February 2020

Knockdown of the Drosophila fused in sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches (English)

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Cabeza Dmel_CG3606

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GOA release 2020-03-11

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Hiroshi Sasayama

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Mai Shimamura

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Takahiko Tokuda

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Yumiko Azuma

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Tomokatsu Yoshida

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Masanori Nakagawa

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Nobuhiro Fujikake

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Yoshitaka Nagai

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Masamitsu Yamaguchi

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19 June 2012

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e39483

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Creative Commons Attribution 4.0 International

19 June 2012

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The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span.

1 reference

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6 July 2018

Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS

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6 July 2018

A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43.

1 reference

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6 July 2018

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

1 reference

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6 July 2018

Implications of the prion-related Q/N domains in TDP-43 and FUS.

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6 July 2018

Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations

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6 July 2018

TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

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6 July 2018

Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules

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6 July 2018

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

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6 July 2018

Extensive FUS-immunoreactive pathology in juvenile amyotrophic lateral sclerosis with basophilic inclusions

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6 July 2018

FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration

1 reference

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6 July 2018

TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

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6 July 2018

Prion-like disorders: blurring the divide between transmissibility and infectivity

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6 July 2018

De novo truncating FUS gene mutation as a cause of sporadic amyotrophic lateral sclerosis

1 reference

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6 July 2018

Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS).

1 reference

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6 July 2018

A Drosophila model for TDP-43 proteinopathy

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6 July 2018

TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration

1 reference

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6 July 2018

Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo

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6 July 2018

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

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6 July 2018

The RNA-binding protein FUS/TLS is a common aggregate-interacting protein in polyglutamine diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378546

6 July 2018

FUS pathology in basophilic inclusion body disease

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6 July 2018

Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis

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6 July 2018

The molecular links between TDP-43 dysfunction and neurodegeneration

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6 July 2018

TARDBP mutations in motoneuron disease with frontotemporal lobar degeneration

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378546

6 July 2018

Rethinking ALS: the FUS about TDP-43.

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6 July 2018

Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

1 reference

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6 July 2018

Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis

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6 July 2018

The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response

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6 July 2018

TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis

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6 July 2018

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

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6 July 2018

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

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6 July 2018

TDP-43 A315T mutation in familial motor neuron disease

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6 July 2018

Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophy

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6 July 2018

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

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6 July 2018

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

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6 July 2018

ALS: a disease of motor neurons and their nonneuronal neighbors

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6 July 2018

Rules for nuclear localization sequence recognition by karyopherin beta 2

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6 July 2018

Mass spectroscopy identifies the splicing-associated proteins, PSF, hnRNP H3, hnRNP A2/B1, and TLS/FUS as interacting partners of the ZNF198 protein associated with rearrangement in myeloproliferative disease

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6 July 2018

Domain architectures and characterization of an RNA-binding protein, TLS

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6 July 2018

Identification of an RNA binding specificity for the potential splicing factor TLS

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6 July 2018

Male sterility and enhanced radiation sensitivity in TLS(-/-) mice

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6 July 2018

Identification of three conserved regions in the DREF transcription factors from Drosophila melanogaster and Drosophila virilis

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6 July 2018

TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378546

6 July 2018

Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma

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6 July 2018

TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domain

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6 July 2018

Cabeza, a Drosophila gene encoding a novel RNA binding protein, shares homology with EWS and TLS, two genes involved in human sarcoma formation

1 reference

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6 July 2018

A stable genomic source of P element transposase in Drosophila melanogaster.

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6 July 2018

The overlap of amyotrophic lateral sclerosis and frontotemporal dementia

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21 January 2018

Continuum of frontal lobe impairment in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0039483

21 January 2018

TDP-43 mutation in familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0039483

21 January 2018

TARDBP variation associated with frontotemporal dementia, supranuclear gaze palsy, and chorea.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0039483

21 January 2018

Novel FUS/TLS mutations and pathology in familial and sporadic amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0039483

21 January 2018

FUS-immunoreactive intranuclear inclusions in neurodegenerative disease.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0039483

21 January 2018

Nuclear transport impairment of amyotrophic lateral sclerosis-linked mutations in FUS/TLS.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0039483

21 January 2018

Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0039483

21 January 2018

Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies.

1 reference

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21 January 2018

Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death.

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21 January 2018

The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology.

1 reference

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21 January 2018

Dominant-negative NSF2 disrupts the structure and function of Drosophila neuromuscular synapses.

1 reference

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21 January 2018

Rapid construction of Drosophila RNAi transgenes using pRISE, a P-element-mediated transformation vector exploiting an in vitro recombination system.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0039483

21 January 2018

Syntrophin-2 is required for eye development in Drosophila

1 reference

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21 January 2018

FUS mutations in frontotemporal lobar degeneration with amyotrophic lateral sclerosis

1 reference

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28 October 2018

Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22724023

12 December 2020

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