A single E627K mutation in the PB2 protein of H9N2 avian influenza virus increases virulence by inducing higher glucocorticoids (GCs) level (Q34311835)

1 August 2017

title

A single E627K mutation in the PB2 protein of H9N2 avian influenza virus increases virulence by inducing higher glucocorticoids (GCs) level (English)

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1 August 2017

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5

Peirong Jiao

1 reference

1 August 2017

Jin Tian

1

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1 August 2017

Wenbao Qi

2

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1 August 2017

Xiaokang Li

3

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1 August 2017

Jun He

4

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1 August 2017

Changhui Zhang

6

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1 August 2017

Guo-Qian Liu

7

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1 August 2017

Ming Liao

8

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1 August 2017

language of work or name

English

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publication date

13 June 2012

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1 August 2017

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1 August 2017

volume

7

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1 August 2017

issue

6

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1 August 2017

page(s)

e38233

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Creative Commons Attribution 4.0 International

1 August 2017

copyright license

start time

13 June 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Biochemical impact of the host adaptation-associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex

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Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation

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Highly pathogenic influenza virus infection of the thymus interferes with T lymphocyte development

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Influenza virus-induced glucocorticoids compromise innate host defense against a secondary bacterial infection

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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A single-amino-acid substitution in a polymerase protein of an H5N1 influenza virus is associated with systemic infection and impaired T-cell activation in mice

6 July 2018

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A novel genotype H9N2 influenza virus possessing human H5N1 internal genomes has been circulating in poultry in eastern China since 1998.

6 July 2018

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Minimal molecular constraints for respiratory droplet transmission of an avian-human H9N2 influenza A virus

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TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection.

6 July 2018

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Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus

6 July 2018

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CD8 T cells utilize TRAIL to control influenza virus infection

6 July 2018

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Evidence of expanded host range and mammalian-associated genetic changes in a duck H9N2 influenza virus following adaptation in quail and chickens.

6 July 2018

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Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

6 July 2018

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6 July 2018

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H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice.

6 July 2018

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6 July 2018

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Glucocorticoids in T cell apoptosis and function.

6 July 2018

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6 July 2018

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Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection

6 July 2018

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CD4(+)CD8(+)TCR(low) thymocytes express low levels of glucocorticoid receptors while being sensitive to glucocorticoid-induced apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374829

Inflammatory responses in influenza A virus infection

6 July 2018

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H9N2 influenza viruses possessing H5N1-like internal genomes continue to circulate in poultry in southeastern China

6 July 2018

1 reference

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Avian-to-human transmission of H9N2 subtype influenza A viruses: relationship between H9N2 and H5N1 human isolates.

6 July 2018

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Depletion of lymphocytes and diminished cytokine production in mice infected with a highly virulent influenza A (H5N1) virus isolated from humans

6 July 2018

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6 July 2018

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Glucocorticoids and immune function: unknown dimensions and new frontiers

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374829

Regulation of apoptosis by viral gene products

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374829

A single amino acid in the PB2 gene of influenza A virus is a determinant of host range.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374829

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6 July 2018

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Characterization of H5N2 influenza viruses isolated in South Korea and their influence on the emergence of a novel H9N2 influenza virus

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374829

Apoptosis of lymphocytes and monocytes infected with influenza virus might be the mechanism of combating virus and causing secondary infection by influenza

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374829

Single mutation at the amino acid position 627 of PB2 that leads to increased virulence of an H5N1 avian influenza virus during adaptation in mice can be compensated by multiple mutations at other sites of PB2.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374829

Multiple amino acid substitutions are involved in the adaptation of H9N2 avian influenza virus to mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374829

Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374829

The stress response and immune function: clinical implications. The 1999 Novera H. Spector Lecture.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374829

Characterization of the pathogenicity of members of the newly established H9N2 influenza virus lineages in Asia

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3374829

Glucocorticoid-induced thymocyte apoptosis: protease-dependent activation of cell shrinkage and DNA degradation

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22719870

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0038233

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1 August 2017

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1 August 2017

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