Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes (Q34307424)

1 August 2017

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title

Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes (English)

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1 August 2017

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C L Hammond

1

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PubMed ID

11451183

1 August 2017

T K Lee

series ordinal

2

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PubMed ID

11451183

1 August 2017

N Ballatori

series ordinal

3

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1 August 2017

1 June 2001

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1 August 2017

Journal of Hepatology

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1 August 2017

34

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1 August 2017

946-954

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1 August 2017

6

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

1 August 2017

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7 January 2021

New developments in glutathione metabolism and their potential application in therapy

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Importance and regulation of hepatic glutathione

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

The physiological consequences of glutathione variations.

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Hepatic glutathione homeostasis in the rat: efflux accounts for glutathione turnover.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Glutathione S-conjugate formation from 1-chloro-2,4-dinitrobenzene and biliary S-conjugate excretion in the perfused rat liver

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Glutathione and Related γ-Glutamyl Compounds: Biosynthesis and Utilization

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Glutathione conjugation and conversion to mercapturic acids can occur as an intrahepatic process

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Glutathione metabolism and its role in hepatotoxicity

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

The Glutathione Status of Cells

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

L-cysteine, a bicarbonate-sensitive endogenous excitotoxin.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

The role of glutathione and glutathione transferases in chemical carcinogenesis

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Glutathione mercaptides as transport forms of metals

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Fas-mediated apoptosis is modulated by intracellular glutathione in human T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Involvement of hydrogen peroxide in topoisomerase inhibitor beta-lapachone-induced apoptosis and differentiation in human leukemia cells.

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Effect of ceramide on intracellular glutathione determines apoptotic or necrotic cell death of JB6 tumor cells

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Apoptosis or necrosis: intracellular levels of glutathione influence mode of cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Differential effects of L-buthionine sulfoximine and ethacrynic acid on glutathione levels and mitochondrial function in PC12 cells

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Glutathione depletion and neuronal cell death: the role of reactive oxygen intermediates and mitochondrial function.

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

GSH extrusion and and the mitochondrial pathway of apoptotic signalling

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Overproduction of Cu/Zn-superoxide dismutase or Bcl-2 prevents the brain mitochondrial respiratory dysfunction induced by glutathione depletion.

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Ebselen induces apoptosis in HepG(2) cells through rapid depletion of intracellular thiols

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

ASTRO research fellowship: the role of BCL-2 and glutathione in an antioxidant pathway to prevent radiation-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

BCL-2 and glutathione: alterations in cellular redox state that regulate apoptosis sensitivity

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Adenovirus-mediated wild-type-p53-gene expression sensitizes TNF-resistant tumor cells to TNF-induced cytotoxicity by altering the cellular redox state

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Expression of Bcl-2 increases intracellular glutathione by inhibiting methionine-dependent GSH efflux.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Role of small heat shock protein HSP25 in radioresistance and glutathione-redox cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Bcl-xL overexpression attenuates glutathione depletion in FL5.12 cells following interleukin-3 withdrawal

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Overexpression of bcl-xL protects astrocytes from glucose deprivation and is associated with higher glutathione, ferritin, and iron levels.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Rescue of cells from apoptosis by inhibition of active GSH extrusion.

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Specific efflux of glutathione from the basolateral membrane domain in polarized MDCK cells during ricin-induced apoptosis

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Glutathione levels determine apoptosis in macrophages

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

CD95-Mediated murine hepatic apoptosis requires an intact glutathione status

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Depletion of hepatic glutathione prevents death receptor-dependent apoptotic and necrotic liver injury in mice

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

A comparative study of apoptosis and necrosis in HepG2 cells: oxidant-induced caspase inactivation leads to necrosis

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Redox regulation of the caspases during apoptosis

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Regulation of gene expression by reactive oxygen

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Suppression of transcription factor NF-kappaB activity by Bcl-2 protein in NIH3T3 cells: implication of a novel NF-kappaB p50-Bcl-2 complex for the anti-apoptotic function of Bcl-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Control of apoptosis by Rel/NF-kappaB transcription factors

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Is NF-kappaB the sensor of oxidative stress?

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal.

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

The inhibition of NF-kappaB activation pathways and the induction of apoptosis by dithiocarbamates in T cells are blocked by the glutathione precursor N-acetyl-L-cysteine

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Optimal NF kappa B mediated transcriptional responses in Jurkat T cells exposed to oxidative stress are dependent on intracellular glutathione and costimulatory signals

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Redox signals and NF-kappaB activation in T cells.

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Antioxidant and redox regulation of gene transcription

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Heterogeneity in c-jun gene expression in normal and malignant cells exposed to either ionizing radiation or hydrogen peroxide

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Heme oxygenase-1 gene expression by a glutathione depletor, phorone, mediated through AP-1 activation in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Involvement of glutathione in induction of c-jun proto-oncogene by methylmethanesulfonate in NIH 3T3 cells

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Induction of heme oxygenase-1 by hypoxia and free radicals in human dermal fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Endogenous glutathione levels modulate both constitutive and UVA radiation/hydrogen peroxide inducible expression of the human heme oxygenase gene

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Thyroid-specific gene expression is differentially influenced by intracellular glutathione level in FRTL-5 cells

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https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Influence of the cellular redox state on NF-kappaB-regulated gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

N-terminal DNA-binding domains contribute to differential DNA-binding specificities of NF-kappa B p50 and p65.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Redox regulation of fos and jun DNA-binding activity in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Expression cloning of a rat liver Na(+)-independent organic anion transporter

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Stable inducible expression of a functional rat liver organic anion transport protein in HeLa cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Oatp2 mediates bidirectional organic solute transport: a role for intracellular glutathione.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

ATP-dependent transport of reduced glutathione on YCF1, the yeast orthologue of mammalian multidrug resistance associated proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Roles of MRP2 and oatp1 in hepatocellular export of reduced glutathione.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

ATP-dependent efflux of calcein by the multidrug resistance protein (MRP): no inhibition by intracellular glutathione depletion.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Buthionine sulphoximine-mediated sensitisation of etoposide-resistant human breast cancer MCF7 cells overexpressing the multidrug resistance-associated protein involves increased drug accumulation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

ATP-dependent transport of aflatoxin B1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

ATPase activity of purified multidrug resistance-associated protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

The effect of glutathione on the ATPase activity of MRP1 in its natural membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Nonequivalent nucleotide trapping in the two nucleotide binding folds of the human multidrug resistance protein MRP1

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Allosteric interactions between the two non-equivalent nucleotide binding domains of multidrug resistance protein MRP1.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR-) rats with conjugated hyperbilirubinemia

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Redox control of ion channel activity in vascular endothelial cells by glutathione

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Glutathione modulates the N-methyl-D-aspartate receptor-activated calcium influx into cultured rat cerebellar granule cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Glutathione is an endogenous ligand of rat brain N-methyl-D-aspartate (NMDA) and 2-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Glutathione and signal transduction in the mammalian CNS.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Redox modulatory site of the NMDA receptor-channel complex: regulation by oxidized glutathione

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Glutathione modulates ryanodine receptor from skeletal muscle sarcoplasmic reticulum. Evidence for redox regulation of the Ca2+ release mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Mutations in the glutathione-gated KefC K+ efflux system of Escherichia coli that cause constitutive activation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

Glutathione and the gated potassium channels of Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

The cloning and DNA sequence of the gene for the glutathione-regulated potassium-efflux system KefC of Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0168-8278%2801%2900037-X

7 January 2021

10.1016/S0168-8278(01)00037-X

Identifiers

DOI

1 reference

1 August 2017

1 reference

PubMed ID

11451183