The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A. (Q34302668)

1 August 2017

The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A. (English)

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1 August 2017

Michael Gassel

1

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1 August 2017

Christine B Breitenlechner

2

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1 August 2017

Norbert König

3

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1 August 2017

Robert Huber

4

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1 August 2017

Richard A Engh

5

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1 August 2017

Dirk Bossemeyer

6

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1 August 2017

language of work or name

English

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publication date

1 March 2004

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Journal of Biological Chemistry

1 August 2017

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1 August 2017

279

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1 August 2017

22

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1 August 2017

23679-23690

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The protein kinase complement of the human genome

1 August 2017

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Structural aspects of protein kinase control-role of conformational flexibility

21 January 2018

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The protein kinase activity modulation sites: mechanisms for cellular regulation - targets for therapeutic intervention

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The conformational plasticity of protein kinases

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A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase

21 January 2018

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Design of allele-specific inhibitors to probe protein kinase signaling

21 January 2018

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Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT)

21 January 2018

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Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity

21 January 2018

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Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential

21 January 2018

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Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase

21 January 2018

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Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity

21 January 2018

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Potent selective inhibitors of protein kinase C

21 January 2018

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Inhibitors of protein kinase C. 2. Substituted bisindolylmaleimides with improved potency and selectivity

21 January 2018

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Inhibitors of protein kinase C. 1. 2,3-bisarylmaleimides

21 January 2018

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Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm

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Identification of PKC-isoform-specific biological actions using pharmacological approaches

21 January 2018

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Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions

21 January 2018

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Protein kinase C alpha (PKC alpha): regulation and biological function

21 January 2018

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Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2

21 January 2018

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Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine

21 January 2018

1 reference

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Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2.

21 January 2018

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Structural basis for Chk1 inhibition by UCN-01

21 January 2018

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(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta

21 January 2018

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Potential new medical therapies for diabetic retinopathy: protein kinase C inhibitors

21 January 2018

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Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

21 January 2018

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Structure of the mammalian catalytic subunit of cAMP-dependent protein kinase and an inhibitor peptide displays an open conformation

21 January 2018

1 reference

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Evidence for an internal entropy contribution to phosphoryl transfer: a study of domain closure, backbone flexibility, and the catalytic cycle of cAMP-dependent protein kinase

21 January 2018

1 reference

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Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure

21 January 2018

1 reference

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Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition

21 January 2018

1 reference

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Alternative binding modes of an inhibitor to two different kinases

21 January 2018

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Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

21 January 2018

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A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility

21 January 2018

1 reference

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Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations

21 January 2018

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The glycine-rich sequence of protein kinases: a multifunctional element

21 January 2018

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pH-dependent binding modes observed in trypsin crystals: lessons for structure-based drug design

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M314082200

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1 August 2017

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