Library screening by means of mass spectrometry (MS) binding assays-exemplarily demonstrated for a pseudostatic library addressing γ-aminobutyric acid (GABA) transporter 1 (GAT1). (Q34300638)

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English	Library screening by means of mass spectrometry (MS) binding assays-exemplarily demonstrated for a pseudostatic library addressing γ-aminobutyric acid (GABA) transporter 1 (GAT1).	scientific article

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scholarly article

1 reference

Europe PubMed Central

1 August 2017

Library screening by means of mass spectrometry (MS) binding assays-exemplarily demonstrated for a pseudostatic library addressing γ-aminobutyric acid (GABA) transporter 1 (GAT1). (English)

1 reference

Europe PubMed Central

1 August 2017

Klaus Theodor Wanner

2

object named as

Klaus T Wanner

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Europe PubMed Central

1 August 2017

author name string

Miriam Sindelar

1

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Europe PubMed Central

1 August 2017

publication date

11 June 2012

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Europe PubMed Central

1 August 2017

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Europe PubMed Central

1 August 2017

7

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Europe PubMed Central

1 August 2017

9

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Europe PubMed Central

1 August 2017

1678-1690

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Europe PubMed Central

1 August 2017

Affinity selection-mass spectrometry and its emerging application to the high throughput screening of G protein-coupled receptors

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Competitive Binding Assays Made Easy with a Native Marker and Mass Spectrometric Quantification

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Drug discovery by dynamic combinatorial libraries

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Supramolecular templating in thermodynamically controlled synthesis

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Direct screening of a dynamic combinatorial library using mass spectrometry

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Electrospray ionisation Fourier-transform ion cyclotron resonance mass spectrometry of dynamic combinatorial libraries

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Dynamic combinatorial mass spectrometry leads to metallo-beta-lactamase inhibitors

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Dynamic combinatorial carbohydrate libraries: probing the binding site of the concanavalin A lectin

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Generation of bis-cationic heterocyclic inhibitors of Bacillus subtilis HPr kinase/phosphatase from a ditopic dynamic combinatorial library

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Dynamic combinatorial chemistry: on the road to fulfilling the promise

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Expanding the scope of MS binding assays to low-affinity markers as exemplified for mGAT1.

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Inhibition of gamma-aminobutyric acid uptake: anatomy, physiology and effects against epileptic seizures

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Basic mechanisms of gabitril (tiagabine) and future potential developments

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Inhibition of GABA uptake in rat brain slices by nipecotic acid, various isoxazoles and related compounds

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GABA uptake inhibitors: relevance to antiepileptic drug research

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Influence of inhibitors of the high affinity GABA uptake on seizure thresholds in mice

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GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors.

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Orally active and potent inhibitors of gamma-aminobutyric acid uptake

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(R)-N-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier

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NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization

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Structure-activity relationships of selective GABA uptake inhibitors.

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Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1.

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Tiagabine in the treatment of epilepsy--a clinical review with a guide for the prescribing physician

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Synthesis of novel GABA uptake inhibitors. Part 6: preparation and evaluation of N-Omega asymmetrically substituted nipecotic acid derivatives

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Comparison of azabicyclic esters and oxadiazoles as ligands for the muscarinic receptor.

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Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4.

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Rate constants for 1,5- and 1,6-hydrogen atom transfer reactions of mono-, di-, and tri-aryl-substituted donors, models for hydrogen atom transfers in polyunsaturated fatty acid radicals

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

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MS-binding assays: kinetic, saturation, and competitive experiments based on quantitation of bound marker as exemplified by the GABA transporter mGAT1

1 reference

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7 January 2021

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10.1002/CMDC.201200201

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

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