Whole-genome sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma. (Q34293927)

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11 February 2020

title

Whole-genome sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma (English)

1 reference

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11 February 2020

main subject

whole genome sequencing

1 reference

6

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11 February 2020

Nathanael G. Bailey

8

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11 February 2020

Govind Bhagat

10

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11 February 2020

Roberto N. Miranda

11

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11 February 2020

Megan S Lim

14

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11 February 2020

Kojo Elenitoba-Johnson

15

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Thirunavukkarasu Velusamy

11 February 2020

2

object named as

Thirunavukkarasu Velusamy

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11 February 2020

author name string

Mark J Kiel

1

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11 February 2020

Bryan L Betz

3

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11 February 2020

Lili Zhao

4

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11 February 2020

Helmut G Weigelin

5

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11 February 2020

David R Huebner-Chan

7

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11 February 2020

David T Yang

9

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David W Bahler

12

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11 February 2020

L Jeffrey Medeiros

13

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11 February 2020

language of work or name

English

0 references

publication date

13 August 2012

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Journal of Experimental Medicine

11 February 2020

published in

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11 February 2020

volume

209

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11 February 2020

page(s)

1553-1565

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issue

9

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Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma.

11 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Analysis of the coding genome of diffuse large B-cell lymphoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

The mutational landscape of head and neck squamous cell carcinoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Notch pathway activation induces neuroblastoma tumor cell growth arrest

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Analysis of genetic inheritance in a family quartet by whole-genome sequencing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

The canonical Notch signaling pathway: unfolding the activation mechanism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Structural basis for autoinhibition of Notch

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Notch signaling in lymphocyte development and function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Splenic marginal zone lymphoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

7q31-32 allelic loss is a frequent finding in splenic marginal zone lymphoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Transduction of Notch2 in feline leukemia virus-induced thymic lymphoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428949

Splenic marginal zone lymphoma: a prognostic model for clinical use.

6 July 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120910

Notch1 expression in early lymphopoiesis influences B versus T lineage determination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120910

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120910

Alteration of BIRC3 and multiple other NF-κB pathway genes in splenic marginal zone lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120910

Cytogenetic aberrations and their prognostic value in a series of 330 splenic marginal zone B-cell lymphomas: a multicenter study of the Splenic B-Cell Lymphoma Group.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120910

Notch2 haploinsufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120910

Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120910

Splenic marginal zone lymphoma: clinical characteristics and prognostic factors in a series of 60 patients

21 January 2018

1 reference

12 December 2020

Deletion mapping on the long arm of chromosome 7 in splenic lymphoma with villous lymphocytes

1 reference

12 December 2020

NOTCH2 mutations in marginal zone lymphoma

1 reference

12 December 2020

Splenic marginal zone lymphoma: characterization of 7q deletion and its value in diagnosis

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20120910

1 reference

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11 February 2020

1 reference

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11 February 2020

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