Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasis (Q34293667)

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English	Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasis	scientific article

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scholarly article

1 reference

Europe PubMed Central

1 August 2017

Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasis (English)

1 reference

Europe PubMed Central

1 August 2017

apoptotic process

1 reference

based on heuristic

inferred from title

author name string

Christina Wanka

1

1 reference

Europe PubMed Central

1 August 2017

Joachim P Steinbach

2

1 reference

Europe PubMed Central

1 August 2017

Johannes Rieger

3

1 reference

Europe PubMed Central

1 August 2017

language of work or name

0 references

publication date

10 August 2012

1 reference

Europe PubMed Central

1 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

1 August 2017

287

1 reference

Europe PubMed Central

1 August 2017

33436-33446

1 reference

Europe PubMed Central

1 August 2017

40

1 reference

Europe PubMed Central

1 August 2017

Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo

1 reference

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Metabolic reprogramming: a cancer hallmark even warburg did not anticipate

1 reference

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6 July 2018

Synthesis of cytochrome C oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death

1 reference

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6 July 2018

Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells

1 reference

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Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer

1 reference

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6 July 2018

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

1 reference

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Lactate-dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1

1 reference

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Silencing of TKTL1 by siRNA inhibits proliferation of human gastric cancer cells in vitro and in vivo

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TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization

1 reference

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6 July 2018

Glycolytic metabolism and tumour response to fractionated irradiation.

1 reference

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Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts.

1 reference

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6 July 2018

Modulation of intracellular ROS levels by TIGAR controls autophagy

1 reference

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Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer

1 reference

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How mitochondria produce reactive oxygen species

1 reference

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ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis

1 reference

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Genetic pathways to primary and secondary glioblastoma

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Pentose phosphate cycle oxidative and nonoxidative balance: A new vulnerable target for overcoming drug resistance in cancer

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TIGAR, a p53-inducible regulator of glycolysis and apoptosis

1 reference

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Tissue metabolism under the influence of low oxygen tension

1 reference

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6 July 2018

p53 regulates mitochondrial respiration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460445

6 July 2018

Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted

1 reference

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The antioxidant function of the p53 tumor suppressor

1 reference

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6 July 2018

Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer

1 reference

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6 July 2018

Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460445

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Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

1 reference

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6 July 2018

On respiratory impairment in cancer cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460445

6 July 2018

On the Origin of Cancer Cells

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Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

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Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo

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Metabolic mapping with bioluminescence: basic and clinical relevance

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Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3460445

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Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress

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Cells overexpressing fructose-2,6-bisphosphatase showed enhanced pentose phosphate pathway flux and resistance to oxidative stress

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Redox-dependent signal transduction

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Stress, superoxide, and signal transduction.

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Necrogenesis and Fas/APO-1 (CD95) expression in primary (de novo) and secondary glioblastomas

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6 July 2018

Reactive oxygen species, mitochondria, apoptosis and aging.

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Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas.

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Requirement for generation of H2O2 for platelet-derived growth factor signal transduction

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DNA-protein cross-linking between thymine and tyrosine in chromatin of gamma-irradiated or H2O2-treated cultured human cells.

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Mitochondrial ROS initiate phosphorylation of p38 MAP kinase during hypoxia in cardiomyocytes

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ROS induced DNA damage and checkpoint responses: influences on aging?

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Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B.

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21 January 2018

Inhibition of epidermal growth factor receptor signaling protects human malignant glioma cells from hypoxia-induced cell death

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The effect of thiamine supplementation on tumour proliferation. A metabolic control analysis study

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Expression of transketolase-like 1 and activation of Akt in grade IV glioblastomas compared with grades II and III astrocytic gliomas.

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https://api.crossref.org/works/10.1074%2FJBC.M112.384578

21 January 2018

Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells

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https://api.crossref.org/works/10.1074%2FJBC.M112.384578

21 January 2018

A noncommercial dual luciferase enzyme assay system for reporter gene analysis

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https://api.crossref.org/works/10.1074%2FJBC.M112.384578

21 January 2018

p53 and its family members -- reporter genes may not see the difference.

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https://api.crossref.org/works/10.1074%2FJBC.M112.384578

21 January 2018

Hypoxia-induced cell death in human malignant glioma cells: energy deprivation promotes decoupling of mitochondrial cytochrome c release from caspase processing and necrotic cell death

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21 January 2018

Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain.

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EFFECT OF ELECTRODE DIMENSIONS ON TISSUE PO-2 MEASUREMENT IN VIVO.

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21 January 2018

Hypoxia and succinate antagonize 2-deoxyglucose effects on glioblastoma

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21 January 2018

Poor outcome in primary non-small cell lung cancers is predicted by transketolase TKTL1 expression

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21 January 2018

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21 January 2018

Baseline levels of glucose metabolites, glutamate and glycerol in malignant glioma assessed by stereotactic microdialysis

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21 January 2018

Metabolomic patterns in glioblastoma and changes during radiotherapy: a clinical microdialysis study

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21 January 2018

TP53 induced glycolysis and apoptosis regulator (TIGAR) knockdown results in radiosensitization of glioma cells.

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21 January 2018

CD95-mediated apoptosis of human glioma cells: modulation by epidermal growth factor receptor activity

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28 October 2018

Transketolase protein TKTL1 overexpression: A potential biomarker and therapeutic target in breast cancer

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https://pubmed.ncbi.nlm.nih.gov/22887998

12 December 2020

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Transketolase-like 1 expression correlates with subtypes of ovarian cancer and the presence of distant metastases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22887998

12 December 2020

based on heuristic

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Nonoxidative pentose phosphate pathways and their direct role in ribose synthesis in tumors: is cancer a disease of cellular glucose metabolism?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22887998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of physiological oxygen concentration on human tumor colony growth in soft agar

1 reference

https://pubmed.ncbi.nlm.nih.gov/22887998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual Role of Reactive Oxygen Species in Vascular Growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/22887998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of O(2)-tension in the inspired air upon the O(2)-tension in the tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/22887998

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Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22887998

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.384578

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

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