Telomere maintenance mechanisms as a target for drug development (Q34293590)

1 August 2017

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title

Telomere maintenance mechanisms as a target for drug development (English)

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1 August 2017

1

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1 August 2017

Hurley LH

2

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1 August 2017

Von Hoff DD

series ordinal

3

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1 August 2017

language of work or name

English

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publication date

1 December 2000

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1 August 2017

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1 August 2017

19

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1 August 2017

56

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1 August 2017

6632-6641

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1204092

1 August 2017

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cites work

Significant telomere shortening in childhood leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Anthracene-9,10-diones as potential anticancer agents. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Human telomeres contain at least three types of G-rich repeat distributed non-randomly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Telomere length predicts replicative capacity of human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Porphyrin binding to quadrupled T4G4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Reconstitution of human telomerase activity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

A nucleic acid triple helix formed by a peptide nucleic acid-DNA complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

A functional telomerase RNA swap in vivo reveals the importance of nontemplate RNA domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Mechanism of telomerase induction during T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Extension of life-span by introduction of telomerase into normal human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Secondary structure of vertebrate telomerase RNA

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Telomere maintenance mechanisms and cellular immortalization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Purification of Tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Telomerase activity in human ovarian carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Poly(ADP-ribose) polymerase: a molecular nick-sensor

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

For better or worse? Telomerase inhibition and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Characterization of a G-quartet formation reaction promoted by the beta-subunit of the Oxytricha telomere-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

The telomerase RNA pseudoknot is critical for the stable assembly of a catalytically active ribonucleoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Specific RNA residue interactions required for enzymatic functions of Tetrahymena telomerase

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Altering specific telomerase RNA template residues affects active site function

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Inhibition of telomerase activity of melanoma cells in vitro by antisense oligonucleotides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Mammalian telomeres end in a large duplex loop

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Creation of human tumour cells with defined genetic elements

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Identification of determinants for inhibitor binding within the RNA active site of human telomerase using PNA scanning

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Cellular delivery of peptide nucleic acids and inhibition of human telomerase

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

G-quadruplex DNA: a potential target for anti-cancer drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Telomere loss: mitotic clock or genetic time bomb?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Telomeres shorten during ageing of human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Human telomerase contains evolutionarily conserved catalytic and structural subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Telomere reduction in human colorectal carcinoma and with ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Length of telomeric repeats in neuroblastoma: correlation with prognosis and other biological characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Functional requirement of p23 and Hsp90 in telomerase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

G-quadruplexes as targets for drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Discovering new ADP-ribose polymer cycles: protecting the genome and more

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Specific association of human telomerase activity with immortal cells and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Sequence-specific DNA recognition by the myb-like domain of the human telomere binding protein TRF1: a model for the protein-DNA complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

2-5A antisense directed against telomerase RNA produces apoptosis in ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Essential role of mouse telomerase in highly proliferative organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Telomere end-replication problem and cell aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Telomerase is controlled by protein kinase Calpha in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

A mutant with a defect in telomere elongation leads to senescence in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Telomerase catalytic subunit homologs from fission yeast and human

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Telomere maintenance in telomerase-deficient mouse embryonic stem cells: characterization of an amplified telomeric DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

The telomerase reverse transcriptase: components and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Reduction of telomeric length and c-erbB-2 gene amplification in human breast cancer, fibroadenoma, and gynecomastia. Relationship to histologic grade and clinical parameters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Telomere changes in human hepatocellular carcinomas and hepatitis virus infected noncancerous livers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Detection of telomerase activity in Chinese hamster V79 cells and its inhibition by 7-deaza-deoxy guanosine triphosphate and (TTAGGG)4 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Strand-invasion of duplex DNA by peptide nucleic acid oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Inhibition of human telomerase by 2'-O-methyl-RNA

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Agents that target telomerase and telomeres

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Photodynamic therapy: a promising new modality for the treatment of cancer.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Preclinical and clinical strategies for development of telomerase and telomere inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

A survey of telomerase activity in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Telomere reduction in endometrial adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

TRF1, a mammalian telomeric protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

The effects of nucleoside analogs on telomerase and telomeres in Tetrahymena

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Substituent position dictates the intercalative DNA-binding mode for anthracene-9,10-dione antitumor drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Template boundary in a yeast telomerase specified by RNA structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

TRF2 Protects Human Telomeres from End-to-End Fusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

21 January 2018

Myc activates telomerase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Origin of Concatemeric T7DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Reconstitution of wild-type or mutant telomerase activity in telomerase-negative immortal human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

Normal human chromosomes have long G-rich telomeric overhangs at one end

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

7 January 2021

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

7 January 2021

Accelerated assembly of G-quadruplex structures by a small molecule

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

7 January 2021

Cooperativity in nicotinamide adenine dinucleotide binding induced by mutations of arginine 475 located at the subunit interface in the human liver mitochondrial class 2 aldehyde dehydrogenase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

7 January 2021

Protein phosphatase 2A inhibits nuclear telomerase activity in human breast cancer cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

7 January 2021

DNA molecules can drive the assembly of other DNA molecules into specific four-stranded structures

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

7 January 2021

BCL-2 antisense therapy in patients with non-Hodgkin lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

7 January 2021

Evidence for a new step in telomere maintenance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204092

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204092

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Dimensions Publication ID

1 August 2017

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1 reference