Effect of spermidine on misfolding and interactions of alpha-synuclein (Q34291522)

1 August 2017

Effect of spermidine on misfolding and interactions of alpha-synuclein (English)

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1 August 2017

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Alexey V Krasnoslobodtsev

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1 August 2017

Jie Peng

2

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1 August 2017

Josephat M Asiago

3

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1 August 2017

Jagadish Hindupur

4

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1 August 2017

Jean-Christophe Rochet

5

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1 August 2017

Yuri L Lyubchenko

6

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1 August 2017

language of work or name

English

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publication date

25 May 2012

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1 August 2017

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1 August 2017

7

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1 August 2017

5

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1 August 2017

e38099

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Creative Commons Attribution 4.0 International

1 August 2017

start time

25 May 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Phosphorylation of α-Synuclein at Y125 and S129 alters its metal binding properties: implications for understanding the role of α-Synuclein in the pathogenesis of Parkinson's Disease and related disorders

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Structural role of compensatory amino acid replacements in the α-synuclein protein.

6 July 2018

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Single-molecule atomic force microscopy force spectroscopy study of Aβ-40 interactions

6 July 2018

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Single molecule characterization of α-synuclein in aggregation-prone states

6 July 2018

1 reference

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Polyamine pathway contributes to the pathogenesis of Parkinson disease

6 July 2018

1 reference

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Nanoimaging for protein misfolding diseases

6 July 2018

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E46K Parkinson's-linked mutation enhances C-terminal-to-N-terminal contacts in alpha-synuclein

6 July 2018

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Structural insights on physiological functions and pathological effects of alpha-synuclein.

6 July 2018

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alpha-Synuclein misfolding: single molecule AFM force spectroscopy study

6 July 2018

1 reference

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Spermine binding to Parkinson's protein alpha-synuclein and its disease-related A30P and A53T mutants

6 July 2018

1 reference

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Characterization of conformational and dynamic properties of natively unfolded human and mouse alpha-synuclein ensembles by NMR: implication for aggregation.

6 July 2018

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Conformational equilibria in monomeric alpha-synuclein at the single-molecule level

6 July 2018

1 reference

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Alpha-synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers

6 July 2018

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Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein

6 July 2018

1 reference

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NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation.

6 July 2018

1 reference

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

6 July 2018

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Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

6 July 2018

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Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein

6 July 2018

1 reference

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A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

6 July 2018

1 reference

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Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein

6 July 2018

1 reference

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Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

6 July 2018

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Unfolding pathways of individual bacteriorhodopsins.

6 July 2018

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Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

6 July 2018

1 reference

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Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360652

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360652

Ionization-reactivity relationships for cysteine thiols in polypeptides.

6 July 2018

1 reference

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

6 July 2018

1 reference

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

6 July 2018

1 reference

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NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360652

Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation

6 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038099

Conformational properties of alpha-synuclein in its free and lipid-associated states

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038099

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

21 January 2018

1 reference

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Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: relevance for Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038099

Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038099

The N-terminal region of non-A beta component of Alzheimer's disease amyloid is responsible for its tendency to assume beta-sheet and aggregate to form fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038099

Cellular polyamines promote the aggregation of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038099

Impact of the acidic C-terminal region comprising amino acids 109-140 on alpha-synuclein aggregation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038099

Solid-state NMR reveals structural differences between fibrils of wild-type and disease-related A53T mutant alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038099

Stabilization of partially folded conformation during alpha-synuclein oligomerization in both purified and cytosolic preparations

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038099

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038099

Pathogenic mutations shift the equilibria of alpha-synuclein single molecules towards structured conformers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038099

Nanomedicine and protein misfolding diseases.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360652

Familial Mutants of α-Synuclein with Increased Neurotoxicity Have a Destabilized Conformation

28 October 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0038099

Protein interactions and misfolding analyzed by AFM force spectroscopy

21 January 2018

1 reference

12 December 2020

Early stages for Parkinson's development: alpha-synuclein misfolding and aggregation

1 reference

12 December 2020

Nanoprobing of α-synuclein misfolding and aggregation with atomic force microscopy

1 reference

12 December 2020

Aluminum-induced structural alterations of the precursor of the non-A beta component of Alzheimer's disease amyloid

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0038099

Identifiers

DOI

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1 August 2017

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1 August 2017

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