Bivalent enzyme inhibitors discovered using dynamic covalent chemistry (Q34287232)

1 August 2017

Bivalent enzyme inhibitors discovered using dynamic covalent chemistry (English)

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1 August 2017

Iain McNae

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Dominic J Campopiano

object named as

Dominic J Campopiano

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author name string

Alexandra J Clipson

1

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1 August 2017

Venugopal T Bhat

2

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1 August 2017

Anne M Caniard

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1 August 2017

Michael F Greaney

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1 August 2017

language of work or name

English

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publication date

10 July 2012

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Chemistry—A European Journal

1 August 2017

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1 August 2017

18

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1 August 2017

34

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1 August 2017

10562-10570

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The advantage of being virtual--target-induced adaptation and selection in dynamic combinatorial libraries

1 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Correlation between host-guest binding and host amplification in simulated dynamic combinatorial libraries.

21 January 2018

1 reference

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Exploring the relation between amplification and binding in dynamic combinatorial libraries of macrocyclic synthetic receptors in water.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Virtual combinatorial libraries: dynamic generation of molecular and supramolecular diversity by self-assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Enzymatic generation and in situ screening of a dynamic combinatorial library of sialic acid analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Fragment-based drug discovery of carbonic anhydrase II inhibitors by dynamic combinatorial chemistry utilizing alkene cross metathesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Site-directed ligand discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Dynamic combinatorial mass spectrometry leads to metallo-beta-lactamase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Combined mass spectrometry and dynamic chemistry approach to identify metalloenzyme inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Direct screening of a dynamic combinatorial library using mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

21 January 2018

Glutathione transferases

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

The role of glutathione-S-transferase in anti-cancer drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Isozyme-specific fluorescent inhibitor of glutathione s-transferase omega 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Rational design of an organometallic glutathione transferase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Overcoming the drug resistance in breast cancer cells by rational design of efficient glutathione S-transferase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Genetic alterations of glutathione S-transferases in asthma: do they modulate lung growth and response to environmental stimuli?

21 January 2018

1 reference

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Regulation of lipopolysaccharide-induced inflammatory response by glutathione S-transferase P1 in RAW264.7 cells

21 January 2018

1 reference

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Design of potent inhibitors for Schistosoma japonica glutathione S-transferase

21 January 2018

1 reference

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Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily

21 January 2018

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https://api.crossref.org/works/10.1002%2FCHEM.201201507

Novel class of bivalent glutathione S-transferase inhibitors

21 January 2018

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https://api.crossref.org/works/10.1002%2FCHEM.201201507

Bivalent inhibitors of glutathione S-transferase: the effect of spacer length on isozyme selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Optimization of bivalent glutathione S-transferase inhibitors by combinatorial linker design

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Discovery of glutathione S-transferase inhibitors using dynamic combinatorial chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Nucleophilic catalysis of acylhydrazone equilibration for protein-directed dynamic covalent chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Nucleophilic catalysis of hydrazone formation and transimination: implications for dynamic covalent chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

4-aminophenylalanine as a biocompatible nucleophilic catalyst for hydrazone ligations at low temperature and neutral pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

From static to dynamic: escaping kinetic traps in hydrazone-based dynamic combinatorial libraries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

A new cyclic pseudopeptide receptor for Li+ from a dynamic combinatorial library

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Simultaneous selection, amplification and isolation of a pseudo-peptide receptor by an immobilised N-methyl ammonium ion template

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Generation of bis-cationic heterocyclic inhibitors of Bacillus subtilis HPr kinase/phosphatase from a ditopic dynamic combinatorial library

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Dynamic combinatorial carbohydrate libraries: probing the binding site of the concanavalin A lectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Dynamic combinatorial libraries of hydrazone-linked pseudo-peptides: dependence of diversity on building block structure and chirality

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Dynamic combinatorial chemistry with hydrazones: cholate-based building blocks and libraries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Dynamic combinatorial chemistry with hydrazones: libraries incorporating heterocyclic and steroidal motifs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Discovery of linear receptors for multiple dihydrogen phosphate ions using dynamic combinatorial chemistry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Ternary resin-bound Dynamic Combinatorial Chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Glutathione S-transferase Pi has at least three distinguishable xenobiotic substrate sites close to its glutathione-binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

The glutathione conjugate of ethacrynic acid can bind to human pi class glutathione transferase P1-1 in two different modes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Glutathione S-transferase polymorphisms: cancer incidence and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Glutathione S-transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Activation of the p38 signaling pathway by heat shock involves the dissociation of glutathione S-transferase Mu from Ask1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Negative regulation of MEKK1-induced signaling by glutathione S-transferase Mu.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Inhibition of human glutathione S-transferases by curcumin and analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Transition state model and mechanism of nucleophilic aromatic substitution reactions catalyzed by human glutathione S-transferase M1a-1a.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Dynamic Combinatorial Chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

GSTM1 and GSTP1 and respiratory health in asthmatic children exposed to ozone

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

Ferrocene-amino acid macrocycles as hydrazone-based receptors for anions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201201507

21 January 2018

Identifiers

DOI

10.1002/CHEM.201201507

1 reference

1 August 2017

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