RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis. (Q34282328)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20595512%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis (English)

1 reference

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6 February 2020

0 references

4

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6 February 2020

5

Lino Tessarollo

1 reference

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6 February 2020

author name string

Ande Satyanarayana

1

1 reference

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6 February 2020

Kristbjorn Orri Gudmundsson

2

1 reference

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6 February 2020

Xiu Chen

3

1 reference

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6 February 2020

Jonathan R Keller

6

1 reference

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6 February 2020

Steven X Hou

7

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6 February 2020

language of work or name

English

0 references

publication date

1 July 2010

1 reference

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6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20595512%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

volume

116

1 reference

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6 February 2020

issue

16

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6 February 2020

page(s)

2921-2931

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Control of cell adhesion dynamics by Rap1 signaling

6 February 2020

cites work

1 reference

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Rap1 maintains adhesion between cells to affect Egfr signaling and planar cell polarity in Drosophila

6 July 2018

1 reference

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Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Both primitive and definitive blood cells are derived from Flk-1+ mesoderm

6 July 2018

1 reference

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Soluble Flt-1 regulates Flk-1 activation to control hematopoietic and endothelial development in an oxygen-responsive manner

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development.

6 July 2018

1 reference

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Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins

6 July 2018

1 reference

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Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice.

6 July 2018

1 reference

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Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafish

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Maturation and enucleation of primitive erythroblasts during mouse embryogenesis is accompanied by changes in cell-surface antigen expression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Rap1: a turnabout for the crosstalk between cadherins and integrins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Essential role of B-Raf in ERK activation during extraembryonic development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Hematopoiesis in the yolk sac: more than meets the eye.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Evidence for the hemangioblast

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Rap1 and SPA-1 in hematologic malignancy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Rap1 GTPase: Functions, Regulation, and Malignancy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Tracking mesoderm induction and its specification to the hemangioblast during embryonic stem cell differentiation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Thrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathways

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Ras and Rap1: two highly related small GTPases with distinct function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Endothelial apoptosis in Braf-deficient mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

The transcriptional control of hematopoiesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Expression of tal-1 and GATA-binding proteins during human hematopoiesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

GATA-binding transcription factors in hematopoietic cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Rap-GEF signaling controls stem cell anchoring to their niche through regulating DE-cadherin-mediated cell adhesion in the Drosophila testis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Rap1A-deficient T and B cells show impaired integrin-mediated cell adhesion

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

A hierarchical order of factors in the generation of FLK1- and SCL-expressing hematopoietic and endothelial progenitors from embryonic stem cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Transcription factors and the regulation of haemopoiesis: lessons from GATA and SCL proteins.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2974602

Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20595512

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Ectopic B-Raf expression enhances extracellular signal-regulated kinase (ERK) signaling in T cells and prevents antigen-presenting cell-induced anergy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20595512

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20595512

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2010-01-262964

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20595512%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20595512%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference