Physiochemical and biochemical factors influencing the pharmacokinetics of antibody therapeutics (Q34275537)

1 August 2017

Physiochemical and biochemical factors influencing the pharmacokinetics of antibody therapeutics (English)

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1 August 2017

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Daniela Bumbaca

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1 August 2017

C Andrew Boswell

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2

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1 August 2017

Paul J Fielder

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3

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1 August 2017

Leslie A Khawli

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4

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1 August 2017

language of work or name

English

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publication date

18 May 2012

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1 August 2017

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1 August 2017

14

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1 August 2017

3

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1 August 2017

554-558

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https://scigraph.springernature.com/pub.10.1208/s12248-012-9369-y

1 August 2017

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cites work

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.

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Monoclonal antibodies: what are the pharmacokinetic and pharmacodynamic considerations for drug development?

6 July 2018

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High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans

6 July 2018

1 reference

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Effects of charge on antibody tissue distribution and pharmacokinetics.

6 July 2018

1 reference

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Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in rats

6 July 2018

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Subcutaneous administration of biotherapeutics: current experience in animal models.

6 July 2018

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Stability of IgG isotypes in serum

6 July 2018

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Subcutaneous bioavailability of golimumab at 3 different injection sites in healthy subjects

6 July 2018

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Biodistribution mechanisms of therapeutic monoclonal antibodies in health and disease

6 July 2018

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CNS delivery via adsorptive transcytosis

6 July 2018

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Factors determining antibody distribution in tumors

6 July 2018

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FcRn: the neonatal Fc receptor comes of age.

6 July 2018

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The pharmacokinetics and pharmacodynamics of monoclonal antibodies--mechanistic modeling applied to drug development.

6 July 2018

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Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types

6 July 2018

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Drug penetration in solid tumours

6 July 2018

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Results of a randomized open-label crossover study of the bioequivalence of subcutaneous versus intramuscular administration of alefacept.

6 July 2018

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Elimination mechanisms of therapeutic monoclonal antibodies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385840

Pharmacokinetics and concentration-effect relationships of therapeutic monoclonal antibodies and fusion proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385840

Mechanisms of aggregate formation and carbohydrate excipient stabilization of lyophilized humanized monoclonal antibody formulations.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385840

Monoclonal antibody radiopharmaceuticals: cationization, pegylation, radiometal chelation, pharmacokinetics, and tumor imaging

6 July 2018

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Transport of molecules, particles, and cells in solid tumors

6 July 2018

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Improved tumor localization and radioimaging with chemically modified monoclonal antibodies

6 July 2018

1 reference

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Effect of C2-associated carbohydrate structure on Ig effector function: studies with chimeric mouse-human IgG1 antibodies in glycosylation mutants of Chinese hamster ovary cells.

6 July 2018

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Studies of aglycosylated chimeric mouse-human IgG. Role of carbohydrate in the structure and effector functions mediated by the human IgG constant region

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385840

Mapping and comparison of the interaction sites on the Fc region of IgG responsible for triggering antibody dependent cellular cytotoxicity (ADCC) through different types of human Fc gamma receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385840

Quantitative prediction of human pharmacokinetics for monoclonal antibodies: retrospective analysis of monkey as a single species for first-in-human prediction.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385840

Translational pharmacokinetics and pharmacodynamics of an FcRn-variant anti-CD4 monoclonal antibody from preclinical model to phase I study

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385840

Reduced elimination of IgG antibodies by engineering the variable region.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385840

Effect of constant and variable domain glycosylation on pharmacokinetics of therapeutic antibodies in mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385840

Imaging tumors with an albumin-binding Fab, a novel tumor-targeting agent.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385840

Heterogeneity of recombinant antibodies: linking structure to function

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385840

Comparison of recombinant derivatives of chimeric TNT-3 antibody for the radioimaging of solid tumors

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385840

In vivo trafficking and catabolism of IgG1 antibodies with Fc associated carbohydrates of differing structure

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385840

Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3385840

Effect of intraperitoneal injection volume and antibody protein dose on the pharmacokinetics of intraperitoneally administered IgG2a kappa murine monoclonal antibody in the rat

28 October 2018

1 reference

12 December 2020

The pharmacokinetic characteristics of glycolated humanized anti-Tac Fabs are determined by their isoelectric points

1 reference

12 December 2020

Monoclonal antibody pharmacokinetics and pharmacodynamics

1 reference

12 December 2020

Engineering human IgG1 affinity to human neonatal Fc receptor: impact of affinity improvement on pharmacokinetics in primates

1 reference

12 December 2020

Pharmacokinetics of humanized monoclonal anti-tumor necrosis factor-{alpha} antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys

1 reference

12 December 2020

10.1208/S12248-012-9369-Y

Identifiers

DOI

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Dimensions Publication ID

1 August 2017

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1 August 2017

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