High glucose dephosphorylates serine 46 and inhibits p53 apoptotic activity (Q34274477)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25260780%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

High glucose dephosphorylates serine 46 and inhibits p53 apoptotic activity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25260780%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

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2

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20 February 2020

author name string

Alessia Garufi

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25260780%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

publication date

27 September 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25260780%20AND%20SRC:MED&resulttype=core&format=json

Journal of Experimental & Clinical Cancer Research

20 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25260780%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

volume

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25260780%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

page(s)

79

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25260780%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

20 February 2020

copyright license

start time

27 September 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1186/s13046-014-0079-4

0 references

cites work

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Role of p53 serine 46 in p53 target gene regulation

6 July 2018

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HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation.

6 July 2018

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6 July 2018

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6 July 2018

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Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis.

6 July 2018

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HIPK2 modulates p53 activity towards pro-apoptotic transcription

6 July 2018

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Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha

6 July 2018

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6 July 2018

Modes of p53 regulation

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Blinded by the Light: The Growing Complexity of p53

6 July 2018

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PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53.

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage

6 July 2018

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HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations.

6 July 2018

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Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified.

6 July 2018

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6 July 2018

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Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

6 July 2018

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6 July 2018

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6 July 2018

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Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.

6 July 2018

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Hyperglycaemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase.

21 January 2018

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Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress

21 January 2018

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A redox-regulated SUMO/acetylation switch of HIPK2 controls the survival threshold to oxidative stress.

21 January 2018

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Conquering the complexity of p53

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25260780

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

HIPK2-induced p53Ser46 phosphorylation activates the KILLER/DR5-mediated caspase-8 extrinsic apoptotic pathway

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25260780

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/S13046-014-0079-4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25260780%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

20 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25260780%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference