Structure-activity analysis of a CFTR channel potentiator: Distinct molecular parts underlie dual gating effects (Q34262476)

1 August 2017

Structure-activity analysis of a CFTR channel potentiator: Distinct molecular parts underlie dual gating effects (English)

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1 August 2017

1

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4 June 2020

author name string

Beáta Töröcsik

series ordinal

2

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4 June 2020

publication date

1 October 2014

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The Journal of General Physiology

1 August 2017

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4 June 2020

volume

144

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4 June 2020

issue

4

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4 June 2020

page(s)

321-336

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Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.

4 June 2020

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Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis

28 July 2018

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Combined effects of VX-770 and VX-809 on several functional abnormalities of F508del-CFTR channels

28 July 2018

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Catalyst-like modulation of transition states for CFTR channel opening and closing: new stimulation strategy exploits nonequilibrium gating

28 July 2018

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Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle

28 July 2018

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Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation

28 July 2018

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New model of cystic fibrosis transmembrane conductance regulator proposes active channel-like conformation.

28 July 2018

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Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809.

28 July 2018

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Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

28 July 2018

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Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations.

28 July 2018

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Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

28 July 2018

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Gating of the CFTR Cl- channel by ATP-driven nucleotide-binding domain dimerisation

28 July 2018

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28 July 2018

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The ABC protein turned chloride channel whose failure causes cystic fibrosis

28 July 2018

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Activating cystic fibrosis transmembrane conductance regulator channels with pore blocker analogs

28 July 2018

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CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains

28 July 2018

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Location of a common inhibitor binding site in the cytoplasmic vestibule of the cystic fibrosis transmembrane conductance regulator chloride channel pore.

28 July 2018

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Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating

28 July 2018

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On the mechanism of MgATP-dependent gating of CFTR Cl- channels

28 July 2018

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The First Nucleotide Binding Domain of Cystic Fibrosis Transmembrane Conductance Regulator Is a Site of Stable Nucleotide Interaction, whereas the Second Is a Site of Rapid Turnover

28 July 2018

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Severed channels probe regulation of gating of cystic fibrosis transmembrane conductance regulator by its cytoplasmic domains

28 July 2018

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Severed molecules functionally define the boundaries of the cystic fibrosis transmembrane conductance regulator's NH(2)-terminal nucleotide binding domain

28 July 2018

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Rapid kinetic analysis of multichannel records by a simultaneous fit to all dwell-time histograms

28 July 2018

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Walker mutations reveal loose relationship between catalytic and channel-gating activities of purified CFTR (cystic fibrosis transmembrane conductance regulator)

28 July 2018

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Multi-Ion mechanism for ion permeation and block in the cystic fibrosis transmembrane conductance regulator chloride channel

28 July 2018

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Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

28 July 2018

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Cl(-)-channel blockers in the thick ascending limb of the loop of Henle. Structure activity relationship

28 July 2018

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An electrostatic interaction between TEA and an introduced pore aromatic drives spring-in-the-door inactivation in Shaker potassium channels

28 July 2018

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A CFTR corrector (lumacaftor) and a CFTR potentiator (ivacaftor) for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation: a phase 2 randomised controlled trial

21 January 2018

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Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

21 January 2018

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Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle

21 January 2018

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Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates

21 January 2018

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Conformational states of CFTR associated with channel gating: the role ATP binding and hydrolysis.

21 January 2018

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Potentiation of disease-associated cystic fibrosis transmembrane conductance regulator mutants by hydrolyzable ATP analogs

21 January 2018

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A CFTR potentiator in patients with cystic fibrosis and the G551D mutation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1085/JGP.201411246

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4 June 2020

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4 June 2020

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