Toll-like receptors; their physiological role and signal transduction system (Q34253911)

31 July 2017

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title

Toll-like receptors; their physiological role and signal transduction system (English)

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31 July 2017

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O Takeuchi

1

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PubMed ID

11357875

31 July 2017

S Akira

series ordinal

2

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31 July 2017

1 April 2001

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International Immunopharmacology

31 July 2017

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31 July 2017

1

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31 July 2017

625-635

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31 July 2017

4

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Innate immunity: the virtues of a nonclonal system of recognition

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

A conserved signaling pathway: the Drosophila toll-dorsal pathway

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https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Antimicrobial peptide defense in Drosophila

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https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Signaling mechanisms in the antimicrobial host defense of Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

A family of human receptors structurally related to Drosophila Toll

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

TLR6: A novel member of an expanding toll-like receptor family

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

1 reference

7 January 2021

Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Bacterial lipopolysaccharide activates NF-kappaB through toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells. Differential expression of TLR-4 and TLR-2 in endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Expression of toll-like receptor 2 on gamma delta T cells bearing invariant V gamma 6/V delta 1 induced by Escherichia coli infection in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

IRAK: a kinase associated with the interleukin-1 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

IL-1 receptor-associated kinase modulates host responsiveness to endotoxin.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

TRAF6 is a signal transducer for interleukin-1

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Limb and skin abnormalities in mice lacking IKKalpha

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

IKK1-deficient mice exhibit abnormal development of skin and skeleton

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

TAK1 mediates an activation signal from toll-like receptor(s) to nuclear factor-kappaB in lipopolysaccharide-stimulated macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Unresponsiveness of MyD88-deficient mice to endotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex

1 reference

https://api.crossref.org/works/10.1016%2FS1567-5769%2801%2900010-8

7 January 2021

10.1016/S1567-5769(01)00010-8

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

11357875