Does the antitumor adenovirus ONYX-015/dl1520 selectively target cells defective in the p53 pathway? (Q34253427)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11356950%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

review article

1 reference

title

Does the antitumor adenovirus ONYX-015/dl1520 selectively target cells defective in the p53 pathway? (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11356950%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11356950%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

author name string

B R Dix

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11356950%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

A W Braithwaite

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11356950%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

language of work or name

English

0 references

publication date

1 June 2001

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7 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11356950%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

volume

75

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7 November 2019

page(s)

5443-5447

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7 November 2019

issue

12

1 reference

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Selective replication and oncolysis in p53 mutant tumors with ONYX-015, an E1B-55kD gene-deleted adenovirus, in patients with advanced head and neck cancer: a phase II trial.

7 November 2019

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1 reference

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a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

6 July 2018

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6 July 2018

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6 July 2018

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ONYX-015 works synergistically with chemotherapy in lung cancer cell lines and primary cultures freshly made from lung cancer patients.

6 July 2018

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6 July 2018

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6 July 2018

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p53-Independent and -dependent requirements for E1B-55K in adenovirus type 5 replication

6 July 2018

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6 July 2018

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The replicative capacities of large E1B-null group A and group C adenoviruses are independent of host cell p53 status

6 July 2018

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p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection

6 July 2018

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Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells.

6 July 2018

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p14ARF links the tumour suppressors RB and p53.

6 July 2018

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p53-dependent cell death/apoptosis is required for a productive adenovirus infection

6 July 2018

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

6 July 2018

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The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis

6 July 2018

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6 July 2018

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

6 July 2018

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p53/E1b58kDa complex regulates adenovirus replication

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Intermediates in the Synthesis of Type 2 Adenovirus Deoxyribonucleic Acid

6 July 2018

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6 July 2018

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6 July 2018

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Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

6 July 2018

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6 July 2018

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Domains required for in vitro association between the cellular p53 and the adenovirus 2 E1B 55K proteins.

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Efficiency of adenovirus-mediated gene transfer to oropharyngeal epithelial cells correlates with cellular differentiation and human coxsackie and adenovirus receptor expression

28 October 2018

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Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015).

28 October 2018

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The role of the E1B 55 kDa gene product in oncolytic adenoviral vectors expressing herpes simplex virus-tk: assessment of antitumor efficacy and toxicity.

28 October 2018

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In vivo antitumor activity of ONYX-015 is influenced by p53 status and is augmented by radiotherapy

28 October 2018

1 reference

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Intravenous administration of ONYX-015, a selectively replicating adenovirus, induces antitumoral efficacy

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=114255

ONYX-015: clinical data are encouraging

28 October 2018

1 reference

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ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

28 October 2018

1 reference

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The transforming oncoproteins determine the mechanism by which p53 suppresses cell transformation: pRb-mediated growth arrest or apoptosis

28 October 2018

1 reference

12 December 2020

The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells

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12 December 2020

Induction of DNA synthesis by adenoviruses in contact-inhibited hamster cells

1 reference

12 December 2020

Effect of adenovirus on host cell DNA synthesis in synchronized cells

1 reference

12 December 2020

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1 reference

12 December 2020

The adenovirus oncoprotein E1a stimulates binding of transcription factor ETF to transcriptionally activate the p53 gene

1 reference

12 December 2020

10.1128/JVI.75.12.5443-5447.2001

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