DNA-binding small molecules as inhibitors of transcription factors (Q34253203)

31 July 2017

DNA-binding small molecules as inhibitors of transcription factors (English)

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31 July 2017

1

Chung-Hang Leung

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31 July 2017

Daniel Shiu-Hin Chan

2

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PubMed ID

22549740

31 July 2017

Victor Pui-Yan Ma

series ordinal

3

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PubMed ID

22549740

31 July 2017

Dik-Lung Ma

series ordinal

4

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31 July 2017

30 April 2012

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Medicinal Research Reviews

31 July 2017

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31 July 2017

33

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31 July 2017

4

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31 July 2017

823-846

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Transcription factors: structural families and principles of DNA recognition

31 July 2017

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Nuclear receptors and inflammatory diseases

21 January 2018

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Transcription-factor mutations and disease

21 January 2018

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Structure and evolution of transcriptional regulatory networks

21 January 2018

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Transcription factors as targets for cancer therapy

21 January 2018

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ETS transcription factors and their emerging roles in human cancer

21 January 2018

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Metastatic bone disease: role of transcription factors and future targets

21 January 2018

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The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome

21 January 2018

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Variation in residual PITX2 activity underlies the phenotypic spectrum of anterior segment developmental disorders.

21 January 2018

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The molecular basis for developmental disorders of the pituitary gland in man.

21 January 2018

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The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation.

21 January 2018

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The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

21 January 2018

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Inflammation meets cancer, with NF-κB as the matchmaker

21 January 2018

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NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

21 January 2018

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Transcription of eukaryotic protein-coding genes

21 January 2018

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The molecular basis of eukaryotic transcription

21 January 2018

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A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II

21 January 2018

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Mediator and the mechanism of transcriptional activation

21 January 2018

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Inhibition of transcription factors with small organic molecules

21 January 2018

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Chemical approaches to transcriptional regulation

21 January 2018

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Small molecule modulators of transcription

21 January 2018

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A complex task? Direct modulation of transcription factors with small molecules

21 January 2018

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Evolution of transcription factors and the gene regulatory network in Escherichia coli

21 January 2018

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Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

21 January 2018

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Strategies for targeting protein-protein interactions with synthetic agents.

21 January 2018

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Transcription factors as targets for DNA-interacting drugs.

21 January 2018

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Effects of anticancer drugs on transcription factor-DNA interactions.

21 January 2018

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Electrophoretic mobility shift assay (EMSA) for detecting protein-nucleic acid interactions

21 January 2018

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Sequence-dependent drug binding to the minor groove of DNA: crystal structure of the DNA dodecamer d(CGCAAATTTGCG)2 complexed with propamidine

21 January 2018

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Criteria for the mode of binding of DNA binding agents.

21 January 2018

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In vitro DNA-binding profile of transcription factors: methods and new insights

21 January 2018

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21 January 2018

Drug--DNA interactions.

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Novel DNA bis-intercalation by MLN944, a potent clinical bisphenazine anticancer drug

21 January 2018

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Antitumor activity of XR5944, a novel and potent topoisomerase poison

21 January 2018

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Dicationic bis(9-methylphenazine-1-carboxamides): relationships between biological activity and linker chain structure for a series of potent topoisomerase targeted anticancer drugs

21 January 2018

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AP-1: a double-edged sword in tumorigenesis

21 January 2018

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Transcription factors control invasion: AP-1 the first among equals

21 January 2018

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Hypoxia-inducible factor 1 (HIF-1) pathway

21 January 2018

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Hypoxia inducible factor-1: a novel target for cancer therapy

21 January 2018

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Regulation of cancer cell metabolism by hypoxia-inducible factor 1.

21 January 2018

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Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

21 January 2018

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Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity

21 January 2018

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Echinomycin Binding Sites on DNA

21 January 2018

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Drug insight: VEGF as a therapeutic target for breast cancer

21 January 2018

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Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy

21 January 2018

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A road map for those who don't know JAK-STAT

21 January 2018

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The STATs of cancer--new molecular targets come of age

21 January 2018

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STATs in cancer inflammation and immunity: a leading role for STAT3

21 January 2018

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Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

21 January 2018

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The formation, isolation and characterization of DNA adducts produced by anticancer platinum complexes

21 January 2018

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Site-specific inhibition of transcription factor binding to DNA by a metallointercalator

21 January 2018

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Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.

21 January 2018

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DNA minor groove binders as potential antitumor and antimicrobial agents

21 January 2018

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DNA minor-groove recognition by small molecules

21 January 2018

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Targeting the minor groove of DNA.

21 January 2018

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The genome as a drug target: sequence specific minor groove binding ligands

21 January 2018

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Molecular recognition of DNA by small molecules

21 January 2018

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Allosteric modulation of DNA by small molecules

21 January 2018

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Structural characterization of a 2:1 distamycin A.d(CGCAAATTGGC) complex by two-dimensional NMR.

21 January 2018

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Antiparallel side-by-side dimeric motif for sequence-specific recognition in the minor groove of DNA by the designed peptide 1-methylimidazole-2-carboxamide netropsin

21 January 2018

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Recognition of DNA by designed ligands at subnanomolar concentrations

21 January 2018

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Expanding the recognition of the minor groove of DNA by incorporation of beta-alanine in hairpin polyamides

21 January 2018

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Completion of a Programmable DNA-Binding Small Molecule Library

21 January 2018

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Recognition of the DNA minor groove by pyrrole-imidazole polyamides

21 January 2018

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Allosteric inhibition of protein--DNA complexes by polyamide--intercalator conjugates

21 January 2018

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Sequence-specific gene silencing in mammalian cells by alkylating pyrrole-imidazole polyamides

21 January 2018

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Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cells

21 January 2018

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Improved nuclear localization of DNA-binding polyamides

21 January 2018

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Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist

21 January 2018

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Exploring the limits of benzimidazole DNA-binding oligomers for the hypoxia inducible factor (HIF) site.

21 January 2018

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Suppression of VEGF transcription in renal cell carcinoma cells by pyrrole-imidazole hairpin polyamides targeting the hypoxia responsive element.

21 January 2018

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Role of transforming growth factor beta in human disease

21 January 2018

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Development of gene silencing pyrrole-imidazole polyamide targeting the TGF-beta1 promoter for treatment of progressive renal diseases

21 January 2018

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Transcriptional inhibition of progressive renal disease by gene silencing pyrrole-imidazole polyamide targeting of the transforming growth factor-β1 promoter.

21 January 2018

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Novel gene silencer pyrrole-imidazole polyamide targeting lectin-like oxidized low-density lipoprotein receptor-1 attenuates restenosis of the artery after injury

21 January 2018

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LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis

21 January 2018

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Modulation of topoisomerase IIalpha expression by a DNA sequence-specific polyamide

21 January 2018

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Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation

21 January 2018

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Androgen receptor in prostate cancer

21 January 2018

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New androgen receptor genomic targets show an interaction with the ETS1 transcription factor.

21 January 2018

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Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide

21 January 2018

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The androgen receptor in hormone-refractory prostate cancer

21 January 2018

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Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide

21 January 2018

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Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites

21 January 2018

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Solution structure of the mithramycin dimer-DNA complex

21 January 2018

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Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78.

21 January 2018

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Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates

21 January 2018

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Direct inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dication

21 January 2018

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Pit-1 is expressed in normal and tumorous human breast and regulates GH secretion and cell proliferation

21 January 2018

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POU domain transcription factors: BRN2 as a regulator of melanocytic growth and tumourigenesis

21 January 2018

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Recognition of ATGA sequences by the unfused aromatic dication DB293 forming stacked dimers in the DNA minor groove

21 January 2018

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Sequence-specific cleavage of double helical DNA by triple helix formation.

21 January 2018

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Specific inhibition of transcription by triple helix-forming oligonucleotides

21 January 2018

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Triplex-forming molecules: from concepts to applications

21 January 2018

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DNA triplex-mediated inhibition of MET leads to cell death and tumor regression in hepatoma.

21 January 2018

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Triplex forming oligonucleotides: sequence-specific tools for gene targeting

21 January 2018

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Targeting DNA with triplex-forming oligonucleotides to modify gene sequence

21 January 2018

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Chemical properties and toxicity of chromium(III) nutritional supplements

21 January 2018

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Specific blocking of CREB/DNA binding by cyclometalated platinum(II) complexes

21 January 2018

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CREB: the unindicted cancer co-conspirator

21 January 2018

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CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy

21 January 2018

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Modulating hypoxia-inducible transcription by disrupting the HIF-1-DNA interface

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MED.21266

1 reference

31 July 2017

1 reference

PubMed ID

22549740