CD19 regulates intrinsic B lymphocyte signal transduction and activation through a novel mechanism of processive amplification (Q34242679)

31 July 2017

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title

CD19 regulates intrinsic B lymphocyte signal transduction and activation through a novel mechanism of processive amplification (English)

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31 July 2017

Fujimoto M

1

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31 July 2017

Poe JC

series ordinal

2

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31 July 2017

Hasegawa M

series ordinal

3

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31 July 2017

Tedder TF

series ordinal

4

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31 July 2017

1 January 2000

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31 July 2017

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31 July 2017

22

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31 July 2017

2-3

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31 July 2017

281-298

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https://scigraph.springernature.com/pub.10.1385/ir:22:2-3:281

31 July 2017

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Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65

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Hyperresponsive B cells in CD22-deficient mice

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Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81.

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CD38 ligation in human B cell progenitors triggers tyrosine phosphorylation of CD19 and association of CD19 with lyn and phosphatidylinositol 3-kinase

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Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice

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Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

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The guanine-nucleotide exchange factor Vav is a crucial regulator of B cell receptor activation and B cell responses to nonrepetitive antigens.

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Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen.

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Syk is required for BCR-mediated activation of p90Rsk, but not p70S6k, via a mitogen-activated protein kinase-independent pathway in B cells

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syk kinase activation by a src kinase-initiated activation loop phosphorylation chain reaction

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Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.

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12 December 2020

Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization

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PI3K: downstream AKTion blocks apoptosis

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Signaling through CD19, Fc receptors or transforming growth factor-β: each inhibits the activation of resting human B cells differently

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12 December 2020

Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.

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Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19

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Quantitative genetic variation in CD19 expression correlates with autoimmunity

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Specific binding of Fyn and phosphatidylinositol 3‐kinase to the B cell surface glycoprotein CD19 through their src homology 2 domains

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12 December 2020

The role of complement and complement receptors in induction and regulation of immunity.

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The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity

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12 December 2020

Specific stimulation of c-Fgr kinase by tyrosine-phosphorylated (poly)peptides--possible implication in the sequential mode of protein phosphorylation

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12 December 2020

The protein product of the proto-oncogene c-cbl forms a complex with phosphatidylinositol 3-kinase p85 and CD19 in anti-IgM-stimulated human B-lymphoma cells

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12 December 2020

CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system

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12 December 2020

Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors

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12 December 2020

CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling.

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12 December 2020

B cell antigen receptor cross-linking induces tyrosine phosphorylation and membrane translocation of a multimeric Shc complex that is augmented by CD19 co-ligation

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12 December 2020

CD19 monoclonal antibody HD37 inhibits anti-immunoglobulin-induced B cell activation and proliferation

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PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

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CD19 as a membrane-anchored adaptor protein of B lymphocytes: costimulation of lipid and protein kinases by recruitment of Vav.

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CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes

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The CD19/CR2/TAPA-1 complex of B lymphocytes: linking natural to acquired immunity

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A role for lipid rafts in B cell antigen receptor signaling and antigen targeting

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Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain

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Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.

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Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors

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12 December 2020

Recognition and specificity in protein tyrosine kinase-mediated signalling

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Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes

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Tissue-specific expression of the human CD19 gene in transgenic mice inhibits antigen-independent B-lymphocyte development.

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12 December 2020

Co-ligation of mouse complement receptors 1 and 2 with surface IgM rescues splenic B cells and WEHI-231 cells from anti-surface IgM-induced apoptosis

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12 December 2020

Introduction: response-regulators of B lymphocyte signaling thresholds provide a context for antigen receptor signal transduction

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12 December 2020

Tyrosine phosphorylation of CD19 in pre-B and mature B cells

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12 December 2020

CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux

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12 December 2020

Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling

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12 December 2020

Membrane rafts and signaling by the multichain immune recognition receptors

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12 December 2020

Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop

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12 December 2020

Convergence of CD19 and B cell antigen receptor signals at MEK1 in the ERK2 activation cascade.

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12 December 2020

SH2 domains recognize specific phosphopeptide sequences

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12 December 2020

CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation

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12 December 2020

Membrane IgM-induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen receptor complex

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12 December 2020

Normal lymphocyte development but delayed humoral immune response in CD81-null mice

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12 December 2020

A requirement for lipid rafts in B cell receptor induced Ca(2+) flux

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12 December 2020

CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice.

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12 December 2020

CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19

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12 December 2020

Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes

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12 December 2020

The CD19/CD21 signal transduction complex of B lymphocytes

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12 December 2020

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

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12 December 2020

CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification

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12 December 2020

Signal transduction through the CD19 receptor during discrete developmental stages of human B-cell ontogeny

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12 December 2020

The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules

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12 December 2020

The CR2/CD19 complex on human B cells contains the src-family kinase Lyn

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12 December 2020

The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation

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12 December 2020

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

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12 December 2020

Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth

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12 December 2020

Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines

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12 December 2020

Rapid redistribution of CD20 to a low density detergent-insoluble membrane compartment

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12 December 2020

Defective B cell development and function in Btk-deficient mice

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12 December 2020

Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

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12 December 2020

CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes

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12 December 2020

CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity

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12 December 2020

Positive and negative roles of the tyrosine kinase Lyn in B cell function

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12 December 2020

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

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12 December 2020

Counterregulation by the Coreceptors CD19 and CD22 of MAP Kinase Activation by Membrane Immunoglobulin

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12 December 2020

The signaling activity of murine CD19 is regulated during cell development

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12 December 2020

Dual antigen recognition by B cells

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12 December 2020

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

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12 December 2020

CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase

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12 December 2020

CD19 regulates B lymphocyte responses to transmembrane signals

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12 December 2020

The CD19 signal transduction complex of B lymphocytes. Deletion of the CD19 cytoplasmic domain alters signal transduction but not complex formation with TAPA-1 and Leu 13.

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12 December 2020

Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity

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12 December 2020

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

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12 December 2020

CD19 and CD22 regulate a B lymphocyte signal transduction pathway that contributes to autoimmunity

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12 December 2020

Alteration of B-cell antigen receptor signaling by CD19 co-ligation. A study with bispecific antibodies.

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12 December 2020

Differential induction of DNA-binding activities following CD19 cross-linking in human B lineage cells

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12 December 2020

Role of CD19 tyrosine 391 in synergistic activation of B lymphocytes by coligation of CD19 and membrane Ig

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12 December 2020

The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19

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12 December 2020

Inhibition of B cell proliferation with anti-CD19 monoclonal antibodies: anti-CD19 antibodies do not interfere with early signaling events triggered by anti-IgM or interleukin 4.

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12 December 2020

Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2

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12 December 2020

SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling

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12 December 2020

Requirement for B cell linker protein (BLNK) in B cell development

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12 December 2020

CD19 regulation of human B cell responses. B cell proliferation and antibody secretion are inhibited or enhanced by ligation of the CD19 surface glycoprotein depending on the stimulating signal used

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12 December 2020

Identifiers

DOI

10.1385/IR:22:2-3:281

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Dimensions Publication ID

31 July 2017

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