Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth (Q34236816)

31 July 2017

Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth (English)

1 reference

31 July 2017

6

Morris F White

1 reference

31 July 2017

2

Sunmin Park

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31 July 2017

1

Xiaocheng Dong

1 reference

31 July 2017

Xueying Lin

3

1 reference

31 July 2017

Kyle Copps

series ordinal

4

1 reference

31 July 2017

Xianjin Yi

series ordinal

5

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31 July 2017

language of work or name

English

0 references

publication date

22 December 2005

1 reference

Journal of Clinical Investigation

31 July 2017

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31 July 2017

116

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31 July 2017

101-114

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31 July 2017

1

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describes a project that uses

31 July 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1319221/fullTextXML

inferred from PubMed Central ID database lookup

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Severe impairment in liver insulin signaling fails to alter hepatic insulin action in conscious mice

28 July 2018

1 reference

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Hypothalamic K(ATP) channels control hepatic glucose production

28 July 2018

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The role of insulin receptor substrate 2 in hypothalamic and beta cell function.

28 July 2018

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

28 July 2018

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Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism

28 July 2018

1 reference

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PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes.

28 July 2018

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Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes.

28 July 2018

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Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

28 July 2018

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Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus

28 July 2018

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Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes

28 July 2018

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Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element

28 July 2018

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Transgenic rescue of insulin receptor-deficient mice

28 July 2018

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Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors

28 July 2018

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Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity

28 July 2018

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Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling

28 July 2018

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Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status.

28 July 2018

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Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation

28 July 2018

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Control of glycogen deposition.

28 July 2018

1 reference

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Insulin receptor substrate-4 signaling in quiescent rat hepatocytes and in regenerating rat liver.

28 July 2018

1 reference

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Differing Roles of Akt and Serum- and Glucocorticoid-regulated Kinase in Glucose Metabolism, DNA Synthesis, and Oncogenic Activity

28 July 2018

1 reference

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Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR.

28 July 2018

1 reference

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Insulin's effect on glucose production: direct or indirect?

28 July 2018

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Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice

28 July 2018

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Regulation of the activity of the pyruvate dehydrogenase complex

28 July 2018

1 reference

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Pdx1 restores beta cell function in Irs2 knockout mice

28 July 2018

1 reference

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Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

28 July 2018

1 reference

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Insulin signalling and the regulation of glucose and lipid metabolism

28 July 2018

1 reference

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GSK3 takes centre stage more than 20 years after its discovery

28 July 2018

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Evidence for a circulating islet cell growth factor in insulin-resistant states

28 July 2018

1 reference

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Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

28 July 2018

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CAP defines a second signalling pathway required for insulin-stimulated glucose transport

28 July 2018

1 reference

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Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover

28 July 2018

1 reference

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Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

28 July 2018

1 reference

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Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain.

28 July 2018

1 reference

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Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck

28 July 2018

1 reference

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Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development

28 July 2018

1 reference

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Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Tyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migration

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Disruption of IRS-2 causes type 2 diabetes in mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Signaling through scaffold, anchoring, and adaptor proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

The IRS-signalling system during insulin and cytokine action

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Metabolism: a higher power for insulin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Type 2 diabetes-a matter of beta-cell life and death?

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Diabetes: outfoxing insulin resistance?

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Lilly lecture 2003: the struggle for mastery in insulin action: from triumvirate to republic

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

SREBPs suppress IRS-2-mediated insulin signalling in the liver.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Molecular insights into insulin action and secretion

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Dual promoter structure of mouse and human fatty acid translocase/CD36 genes and unique transcriptional activation by peroxisome proliferator-activated receptor alpha and gamma ligands

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Insulin signaling after exercise in insulin receptor substrate-2-deficient mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Liver-derived IGF-I is of importance for normal carbohydrate and lipid metabolism.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

The functional significance of Shc in insulin signaling as a substrate of the insulin receptor

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1319221

DNA excision in liver by an albumin-Cre transgene occurs progressively with age

28 October 2018

1 reference

12 December 2020

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

1 reference

12 December 2020

IRS-2 pathways integrate female reproduction and energy homeostasis

1 reference

12 December 2020

Insulin signaling in health and disease

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI25735

1 reference

31 July 2017

1 reference

31 July 2017

1 reference