RNAi or overexpression: alternative therapies for Spinocerebellar Ataxia Type 1 (Q34235172)

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28 February 2020

title

RNAi or overexpression: alternative therapies for Spinocerebellar Ataxia Type 1 (English)

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28 February 2020

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spinocerebellar ataxia type 1

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3

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28 February 2020

author name string

Megan S Keiser

1

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28 February 2020

James C Geoghegan

2

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28 February 2020

Kim A Lennox

4

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28 February 2020

Beverly L Davidson

5

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28 February 2020

publication date

10 April 2013

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28 February 2020

published in

Neurobiology of Disease

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28 February 2020

volume

56

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28 February 2020

page(s)

6-13

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siSPOTR: a tool for designing highly specific and potent siRNAs for human and mouse.

28 February 2020

cites work

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6 July 2018

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Oral zinc sulphate supplementation for six months in SCA2 patients: a randomized, double-blind, placebo-controlled trial.

6 July 2018

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Current prospects for RNA interference-based therapies

6 July 2018

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A simple composite phenotype scoring system for evaluating mouse models of cerebellar ataxia.

6 July 2018

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Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice.

6 July 2018

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6 July 2018

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Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease

6 July 2018

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Minimizing variables among hairpin-based RNAi vectors reveals the potency of shRNAs

6 July 2018

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Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi

6 July 2018

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Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

6 July 2018

1 reference

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MicroRNA expression profiling of single whole embryonic stem cells

6 July 2018

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Real-time quantification of microRNAs by stem-loop RT-PCR

6 July 2018

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Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1.

6 July 2018

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RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

6 July 2018

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Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

6 July 2018

1 reference

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Insect cells as a factory to produce adeno-associated virus type 2 vectors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4173078

siRNA-mediated gene silencing in vitro and in vivo.

6 July 2018

1 reference

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Reduced immunoreactivity to calcium-binding proteins in Purkinje cells precedes onset of ataxia in spinocerebellar ataxia-1 transgenic mice.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4173078

Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1.

6 July 2018

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Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation.

6 July 2018

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Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4173078

ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4173078

Silencing primary dystonia: lentiviral-mediated RNA interference therapy for DYT1 dystonia.

28 October 2018

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Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice.

28 October 2018

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RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

28 October 2018

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Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

28 October 2018

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Purkinje cell expression of a mutant allele of SCA1 in transgenic mice leads to disparate effects on motor behaviors, followed by a progressive cerebellar dysfunction and histological alterations.

28 October 2018

1 reference

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Spinocerebellar ataxia: variable age of onset and linkage to human leukocyte antigen in a large kindred.

28 October 2018

1 reference

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Relationship between ataxin-1 nuclear inclusions and Purkinje cell specific proteins in SCA-1 transgenic mice

28 October 2018

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12 December 2020

The AXH module: an independently folded domain common to ataxin-1 and HBP1

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12 December 2020

Spinocerebellar ataxia type 1

1 reference

12 December 2020

SCA1 transgenic mice: A model for neurodegeneration caused by an expanded CAG trinucleotide repeat

1 reference

12 December 2020

10.1016/J.NBD.2013.04.003

Identifiers

DOI

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28 February 2020

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28 February 2020

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