Inhibition of phosphodiestrase 9 induces cGMP accumulation and apoptosis in human breast cancer cell lines, MCF-7 and MDA-MB-468. (Q34216942)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22469131%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

title

Inhibition of phosphodiestrase 9 induces cGMP accumulation and apoptosis in human breast cancer cell lines, MCF-7 and MDA-MB-468 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22469131%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496613&resulttype=core&format=json

14 May 2020

author name string

R Saravani

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496613&resulttype=core&format=json

14 May 2020

F Karami-Tehrani

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496613&resulttype=core&format=json

14 May 2020

M Aghaei

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496613&resulttype=core&format=json

14 May 2020

R Edalat

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496613&resulttype=core&format=json

14 May 2020

publication date

2 April 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22469131%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496613&resulttype=core&format=json

14 May 2020

volume

45

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496613&resulttype=core&format=json

14 May 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496613&resulttype=core&format=json

14 May 2020

page(s)

199-206

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496613&resulttype=core&format=json

Identification and distribution of different mRNA variants produced by differential splicing in the human phosphodiesterase 9A gene

14 May 2020

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Signalling by cGMP-dependent protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Evidence for the involvement of cGMP and protein kinase G in nitric oxide-induced apoptosis in the pancreatic B-cell line, HIT-T15.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Selective blockade of phosphodiesterase types 2, 5 and 9 results in cyclic 3'5' guanosine monophosphate accumulation in retinal pigment epithelium cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive funct

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Induction of apoptosis by an inhibitor of cAMP-specific PDE in malignant murine carcinoma cells overexpressing PDE activity in comparison to their nonmalignant counterparts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Targeting cancer with phosphodiesterase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Colon Tumor Cell Growth–Inhibitory Activity of Sulindac Sulfide and Other Nonsteroidal Anti-Inflammatory Drugs Is Associated with Phosphodiesterase 5 Inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

In vivo activation of cAMP signaling induces growth arrest and differentiation in acute promyelocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

The type IV phosphodiesterase inhibitor rolipram induces expression of the cell cycle inhibitors p21(Cip1) and p27(Kip1), resulting in growth inhibition, increased differentiation, and subsequent apoptosis of malignant A-172 glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Molecular mechanisms of A3 adenosine receptor-induced G1 cell cycle arrest and apoptosis in androgen-dependent and independent prostate cancer cell lines: involvement of intrinsic pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Hyperoxia increases phosphodiesterase 5 expression and activity in ovine fetal pulmonary artery smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Cyclic GMP induced apoptosis via protein kinase G in oestrogen receptor-positive and -negative breast cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Adenosine and deoxyadenosine induces apoptosis in oestrogen receptor-positive and -negative human breast cancer cells via the intrinsic pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines: the role of ROS and the effect of metal ions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Selective phosphodiesterase inhibitors: a promising target for cognition enhancement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Phosphodiesterase inhibitors as anti-cancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Cyclic 3',5'-nucleotide phosphodiesterases: potential targets for anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Regulation of p53 and suppression of apoptosis by the soluble guanylyl cyclase/cGMP pathway in human ovarian cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Adenosine triphosphate induces activation of caspase-3 in apoptosis of human granulosa-luteal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Effect of protein kinase C alpha, caspase-3, and survivin on apoptosis of oral cancer cells induced by staurosporine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2184.2012.00819.X

Nitric oxide induces apoptotic death of cardiomyocytes via a cyclic-GMP-dependent pathway

21 January 2018

1 reference

12 December 2020

Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects

1 reference

12 December 2020

Signal transduction by cGMP-dependent protein kinases and their emerging roles in the regulation of cell adhesion and gene expression

1 reference

12 December 2020

Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis

1 reference

12 December 2020

Characterization of the first potent and selective PDE9 inhibitor using a cGMP reporter cell line

1 reference

12 December 2020

10.1111/J.1365-2184.2012.00819.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496613&resulttype=core&format=json

14 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496613&resulttype=core&format=json

14 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496613&resulttype=core&format=json