Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase (Q34208791)

31 July 2017

title

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase (English)

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31 July 2017

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Julie Adam

9

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Patrick J Pollard

Patrick J Pollard

13

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Eyal Gottlieb

Eyal Gottlieb

18

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Christian Frezza

Christian Frezza

1

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Eytan Ruppin

17

Eytan Ruppin

1 reference

31 July 2017

12

Ian P M Tomlinson

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31 July 2017

15

Ralph J Deberardinis

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31 July 2017

Liang Zheng

2

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31 July 2017

Ori Folger

3

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31 July 2017

Kartik N Rajagopalan

4

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31 July 2017

Elaine D MacKenzie

5

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31 July 2017

Livnat Jerby

6

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31 July 2017

Massimo Micaroni

7

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31 July 2017

Barbara Chaneton

8

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31 July 2017

Ann Hedley

10

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31 July 2017

Gabriela Kalna

11

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31 July 2017

Dave G Watson

14

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31 July 2017

Tomer Shlomi

16

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31 July 2017

language of work or name

English

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publication date

17 August 2011

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31 July 2017

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31 July 2017

volume

477

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31 July 2017

issue

7363

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31 July 2017

page(s)

225-228

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describes a project that uses

31 July 2017

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Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10363

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10363

Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10363

Inborn and acquired metabolic defects in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10363

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10363

UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10363

Genome-scale microbial in silico models: the constraints-based approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10363

Predicting selective drug targets in cancer through metabolic networks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10363

Computational reconstruction of tissue‐specific metabolic models: application to human liver metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10363

A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10363

Global reconstruction of the human metabolic network based on genomic and bibliomic data

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10363

What is flux balance analysis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10363

Distinct expression profile in fumarate-hydratase-deficient uterine fibroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10363

The effects of metalloporphyrins, porphyrins and metals on the activity of delta-aminolevulinic acid synthase in monolayers of chick embryo liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10363

Open-label study of hemin for acute porphyria: clinical practice implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10363

Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10363

Immortalized mouse epithelial cell models to study the role of apoptosis in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10363

Inhibition of mitochondrial fission favours mutant over wild-type mitochondrial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10363

Clonogenic assay of cells in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10363

Heme transport exhibits polarity in Caco-2 cells: evidence for an active and membrane protein-mediated process.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10363

Sulforhodamine B colorimetric assay for cytotoxicity screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE10363

Multiple knockout analysis of genetic robustness in the yeast metabolic network

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21849978

12 December 2020

inferred from PubMed ID database lookup

Zinc protoporphyrin: A metabolite with a mission.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21849978

12 December 2020

inferred from PubMed ID database lookup

Correction of 13C mass isotopomer distributions for natural stable isotope abundance

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21849978

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NATURE10363

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Dimensions Publication ID

31 July 2017

1044931865

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Fatcat ID

release_narmnzwv5ffrfbnjljwg5h2l6u

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/narmnzwv5ffrfbnjljwg5h2l6u

24 November 2022

mapped directly with Wikidata item

1 reference