Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism (Q34202240)

31 July 2017

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title

Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism (English)

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31 July 2017

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Kentaro Hanada

1

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PubMed ID

12782147

31 July 2017

language of work or name

English

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publication date

1 June 2003

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Biochimica et Biophysica Acta

31 July 2017

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31 July 2017

1632

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31 July 2017

16-30

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31 July 2017

1-3

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Ceramide in the eukaryotic stress response

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Signal transduction of stress via ceramide

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Sphingolipid metabolism and cell growth regulation.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Insolubility of lipids in triton X-100: physical origin and relationship to sphingolipid/cholesterol membrane domains (rafts).

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Both sphingolipids and cholesterol participate in the detergent insolubility of alkaline phosphatase, a glycosylphosphatidylinositol-anchored protein, in mammalian membranes.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Reduction of sphingomyelin level without accumulation of ceramide in Chinese hamster ovary cells affects detergent-resistant membrane domains and enhances cellular cholesterol efflux to methyl-beta -cyclodextrin.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Functional rafts in cell membranes

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Skin barrier structure and function: the single gel phase model

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Sphingolipid long chain bases

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Sphingolipids in lower animals

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Sphingolipid functions in Saccharomyces cerevisiae: comparison to mammals

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

The cell envelope structure of the lipopolysaccharide-lacking gram-negative bacterium Sphingomonas paucimobilis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Metabolism of Sphingosine Bases, V. Biosynthesis of Dihydrosphingosinein vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Sphingolipid long-chain-base auxotrophs of Saccharomyces cerevisiae: genetics, physiology, and a method for their selection

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Characterization of enzymatic synthesis of sphingolipid long-chain bases in Saccharomyces cerevisiae: mutant strains exhibiting long-chain-base auxotrophy are deficient in serine palmitoyltransferase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Mammalian cell mutants resistant to a sphingomyelin-directed cytolysin. Genetic and biochemical evidence for complex formation of the LCB1 protein with the LCB2 protein for serine palmitoyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

De novo synthesis of sphingolipids is required for cell survival by down-regulating c-Jun N-terminal kinase in Drosophila imaginal discs

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Cloning and characterization of LCB1, a Saccharomyces gene required for biosynthesis of the long-chain base component of sphingolipids

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Localization, topology, and function of the LCB1 subunit of serine palmitoyltransferase in mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Enzymology of long-chain base synthesis by liver: characterization of serine palmitoyltransferase in rat liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniques

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Mutations in the Lcb2p subunit of serine palmitoyltransferase eliminate the requirement for the TSC3 gene in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

The biosynthesis of dihydrosphingosine in cell-free preparations of Hansenula ciferri

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

2-Amino-3-ketobutyrate CoA ligase of Escherichia coli: stoichiometry of pyridoxal phosphate binding and location of the pyridoxyllysine peptide in the primary structure of the enzyme.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

A water-soluble homodimeric serine palmitoyltransferase from Sphingomonas paucimobilis EY2395T strain. Purification, characterization, cloning, and overproduction

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Biosynthesis of sphingolipid bases. IV. The biosynthetic origin of sphingosine in Hansenula ciferri

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Mechanism and stereochemistry of the 5-aminolaevulinate synthetase reaction

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Mechanistic studies on the 8-amino-7-oxopelargonate synthase, a pyridoxal-5'-phosphate-dependent enzyme involved in biotin biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Slow-binding and competitive inhibition of 8-amino-7-oxopelargonate synthase, a pyridoxal-5'-phosphate-dependent enzyme involved in biotin biosynthesis, by substrate and intermediate analogs. Kinetic and binding studies

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Mechanism of 8-amino-7-oxononanoate synthase: spectroscopic, kinetic, and crystallographic studies

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Characterization of serine palmitoyltransferase activity in Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

The quantitation of long-chain acyl-CoA in mammalian tissue

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Improved and simplified tissue extraction method for quantitating long-chain acyl-coenzyme A thioesters with picomolar detection using high-performance liquid chromatography

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

A fast and versatile method for extraction and quantitation of long-chain acyl-CoA esters from tissue: content of individual long-chain acyl-CoA esters in various tissues from fed rat

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Identification and quantitation of the fatty acids composing the CoA ester pool of bovine retina, heart, and liver

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

D-Serine inhibits serine palmitoyltransferase, the enzyme catalyzing the initial step of sphingolipid biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

The presence of free D-serine in rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Distribution of free D-serine in vertebrate brains.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Inhibition of serine palmitoyl-transferase activity by lipoxamycin

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

The identification of myriocin-binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Viridiofungins, novel inhibitors of sphingolipid synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Antimicrobial activity of viridiofungins

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Inhibition of serine palmitoyltransferase in vitro and long-chain base biosynthesis in intact Chinese hamster ovary cells by beta-chloroalanine

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Specificity of inhibitors of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis, in intact cells. A novel evaluation system using an SPT-defective mammalian cell mutant

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Dual roles of sphingolipids in signaling of the escape from and onset of apoptosis in a mouse cytotoxic T-cell line, CTLL-2.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Serine palmitoyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Sphingomyelin metabolism is developmentally regulated in rat lung

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Undernutrition decreases serine palmitoyltransferase activity in developing rat hypothalamus.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Tumor necrosis factor mediates the effects of endotoxin on cholesterol and triglyceride metabolism in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Structural and biochemical basis for the UVB-induced alterations in epidermal barrier function.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Palmitate-induced apoptosis can occur through a ceramide-independent pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Dealing with energy demand: the AMP-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Production of ceramides causes apoptosis during early neural differentiation in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Acute activation of de novo sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

A role for the de novo sphingolipids in apoptosis of photosensitized cells

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Sphingolipid biosynthesis in cultured neurons. Down-regulation of serine palmitoyltransferase by sphingoid bases

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Metabolism of short-chain ceramide and dihydroceramide analogues in Chinese hamster ovary (CHO) cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

1-Methylthiodihydroceramide, a novel analog of dihydroceramide, stimulates sphinganine degradation resulting in decreased de novo sphingolipid biosynthesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Cholesterol consumption alters hepatic sphingomyelin metabolism in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

The rate of sphingomyelin synthesis de novo is influenced by the level of cholesterol in cultured human skin fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Regulation of gene expression by SREBP and SCAP.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Sphingolipid biosynthesis by rat liver cells: effects of serine, fatty acids and lipoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Formation of endogenous free sphingoid bases in cells induced by changing medium conditions

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Identification of ammonium ion and 2,6-bis(omega-aminobutyl)- 3, 5-diiminopiperazine as endogenous factors that account for the "burst" of sphingosine upon changing the medium of J774 cells in culture

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

SPTLC1 is mutated in hereditary sensory neuropathy, type 1

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Multiple sequence alignment with hierarchical clustering

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

CLUSTAL: a package for performing multiple sequence alignment on a microcomputer

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Total synthesis of (+)-thermozymocidin (myriocin) from D-fructose

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Isolation, structural elucidation and biological properties of neoenactins B1, B2, M1 and M2, neoenactin congeners

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Activation of the de novo biosynthesis of sphingolipids mediates angiotensin II type 2 receptor-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Hexachlorobenzene-induced alterations on neutral and acidic sphingomyelinases and serine palmitoyltransferase activities. A time course study in two strains of rats

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2803%2900059-3

7 January 2021

10.1016/S1388-1981(03)00059-3

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

12782147