Glutathione – Functions and Metabolism in the Malarial Parasite Plasmodium falciparum (Q34197581)

31 July 2017

1 reference

title

Glutathione--functions and metabolism in the malarial parasite Plasmodium falciparum (English)

1 reference

31 July 2017

Glutathione – Functions and Metabolism in the Malarial Parasite Plasmodium falciparum (English)

1 reference

3 January 2024

main subject

Plasmodium falciparum

0 references

0 references

1 reference

3 January 2024

1

Katja Becker

1 reference

31 July 2017

Stefan Rahlfs

2

1 reference

31 July 2017

Christine Nickel

3

1 reference

31 July 2017

R. Heiner Schirmer

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12751785

3 January 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12751785

3 January 2024

publication date

1 April 2003

1 reference

full work available at URL

31 July 2017

https://www.degruyter.com/document/doi/10.1515/BC.2003.063/pdf

1 reference

3 January 2024

1 reference

31 July 2017

384

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31 July 2017

4

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31 July 2017

551-566

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Physiological functions of thioredoxin and thioredoxin reductase

31 July 2017

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Origin of reactive oxygen species in erythrocytes infected with Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

The malaria parasite supplies glutathione to its host cell--investigation of glutathione transport and metabolism in human erythrocytes infected with Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Hexose-monophosphate shunt activity in intact Plasmodium falciparum-infected erythrocytes and in free parasites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

1,3-Bis(2-chloroethyl)-1-nitrosourea as thiol-carbamoylating agent in biological systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Flavin analogs with antimalarial activity as glutathione reductase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Redox processes in malaria and other parasitic diseases. Determination of intracellular glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Presence of an endogenous superoxide dismutase activity in three rodent malaria species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Structure-function analysis of yeast Grx5 monothiol glutaredoxin defines essential amino acids for the function of the protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

The putative gene for the first enzyme of glutathione biosynthesis in Plasmodium berghei and Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Kinetic characterization of glutathione reductase from the malarial parasite Plasmodium falciparum. Comparison with the human enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Structural and functional characterization of the mutant Escherichia coli glutaredoxin (C14----S) and its mixed disulfide with glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Glutathionylation of human thioredoxin: a possible crosstalk between the glutathione and thioredoxin systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

The yeast glutaredoxins are active as glutathione peroxidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

S-glutathionylation of glyceraldehyde-3-phosphate dehydrogenase: role of thiol oxidation and catalysis by glutaredoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Plasmodium berghei: implication of intracellular glutathione and its related enzyme in chloroquine resistance in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Dependence of plasmodial glutathione metabolism on the host cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Malaria Parasites Adopt Host Cell Superoxide Dismutase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Oxidant defense enzymes of Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Kinetics of inhibition of glutathione-mediated degradation of ferriprotoporphyrin IX by antimalarial drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Molecular cloning and characterization of a putative glutathione reductase gene, the PfGR2 gene, from Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Recombinant Plasmodium falciparum glutathione reductase is inhibited by the antimalarial dye methylene blue

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Glutathione and trypanothione in parasitic hydroperoxide metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Oxidant damage mediates variant red cell resistance to malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Glutathione and peroxide metabolism in malaria-parasitized erythrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Molecular characterization of the glutathione peroxidase gene of the human malaria parasite Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Increase in glutathione peroxidase activity in malaria parasite after selenium supplementation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Genome sequence of the human malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Deletion of the parasite-specific insertions and mutation of the catalytic triad in glutathione reductase from chloroquine-sensitive Plasmodium falciparum 3D7

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Resistance of glucose-6-phosphate dehydrogenase deficiency to malaria: effects of fava bean hydroxypyrimidine glucosides on Plasmodium falciparum growth in culture and on the phagocytosis of infected cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Growth of Plasmodium falciparum induces stage-dependent haemichrome formation, oxidative aggregation of band 3, membrane deposition of complement and antibodies, and phagocytosis of parasitized erythrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Biochemical and electron paramagnetic resonance study of the iron superoxide dismutase from Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Antiplasmodial activity of nitroaromatic and quinoidal compounds: redox potential vs. inhibition of erythrocyte glutathione reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Biologic and pharmacologic regulation of mammalian glutathione synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Glutathione S-transferase of the malarial parasite Plasmodium falciparum: characterization of a potential drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Nucleoredoxin, glutaredoxin, and thioredoxin differentially regulate NF-kappaB, AP-1, and CREB activation in HEK293 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Antioxidant function of thioredoxin and glutaredoxin systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Vitamin C redox reactions in blood of normal and malaria-infected mice studied with isoascorbate as a nonisotopic marker

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

The thioredoxin system of the malaria parasite Plasmodium falciparum. Glutathione reduction revisited.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Substrate binding and catalysis by glutathione reductase as derived from refined enzyme: substrate crystal structures at 2 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Inhibition of human glutathione reductase by the nitrosourea drugs 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea. A crystallographic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Molecular cloning and characterization of a peroxiredoxin from the human malaria parasite Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Molecular characterization of a 2-Cys peroxiredoxin from the human malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Glutathione reductase and glutamate dehydrogenase of Plasmodium falciparum, the causative agent of tropical malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Enzymes of parasite thiol metabolism as drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

The malaria parasite Plasmodium falciparum possesses a functional thioredoxin system

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Isolation and functional analysis of two thioredoxin peroxidases (peroxiredoxins) from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Expression and characterization of glucose-6-phosphate dehydrogenase of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

GSH-dependent peroxidase activity of the rice (Oryza sativa) glutaredoxin, a thioltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

The glutathione S-transferase from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

The putative gamma-glutamylcysteine synthetase from Plasmodium falciparum contains large insertions and a variable tandem repeat

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Plasmodium falciparum-infected red blood cells depend on a functional glutathione de novo synthesis attributable to an enhanced loss of glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Inhibitors of glutathione reductase as potential antimalarial drugs. Kinetic cooperativity and effect of dimethyl sulphoxide on inhibition kinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Thioredoxin--a fold for all reasons

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Peroxidoxins: a new antioxidant family

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Regulation of intracellular glutathione levels in erythrocytes infected with chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Glutathione synthetase from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Plasmodium falciparum: thiol status and growth in normal and glucose-6-phosphate dehydrogenase deficient human erythrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Thioredoxin and glutathione system of malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Folding of the four domains and dimerization are impaired by the Gly446-->Glu exchange in human glutathione reductase. Implications for the design of antiparasitic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Denaturation and reactivation of dimeric human glutathione reductase--an assay for folding inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Cloning of the glucose 6-phosphate dehydrogenase gene from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Hydrogen peroxide increases the activity of gamma-glutamylcysteine synthetase in cultured Chinese hamster V79 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Role of glutathione in the detoxification of ferriprotoporphyrin IX in chloroquine resistant Plasmodium berghei

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Glutaredoxins catalyze the reduction of glutathione by dihydrolipoamide with high efficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Thioredoxin peroxidases of the malarial parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Plasmodium falciparum possesses a classical glutaredoxin and a second, glutaredoxin-like protein with a PICOT homology domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

The thioredoxin system of Plasmodium falciparum and other parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Medical need, scientific opportunity and the drive for antimalarial drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Glutathione stability and oxidative stress in P. falciparum infection in vitro: responses of normal and G6PD deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Ribose metabolism and nucleic acid synthesis in normal and glucose-6-phosphate dehydrogenase-deficient human erythrocytes infected with Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Glucose-6-phosphate dehydrogenase deficiency and malaria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Kinetics and crystallographic analysis of human glutathione reductase in complex with a xanthene inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Evidence that peroxiredoxins are novel members of the thioredoxin fold superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Malaria-parasitized erythrocytes and hemozoin nonenzymatically generate large amounts of hydroxy fatty acids that inhibit monocyte functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Plasmodium berghei: oxidant defense system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Regulation of protein S-thiolation by glutaredoxin 5 in the yeast Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

The glutamate dehydrogenase of Plasmodium lophurae (avian malaria).

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Role of glutaredoxin in metabolic oxidative stress. Glutaredoxin as a sensor of oxidative stress mediated by H2O2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Glutathione-S-transferase activity in malarial parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Oxidative stress and protective mechanisms in erythrocytes in relation to Plasmodium vinckei load

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

The putative glutathione peroxidase gene of Plasmodium falciparum codes for a thioredoxin peroxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

An electron cytochemical study of 6-phosphogluconate dehydrogenase activity in infected erythrocytes during malaria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Expression and characterization of human glutamate-cysteine ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Oxidants, oxidant drugs, and malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Glutamate dehydrogenase, the marker protein of Plasmodium falciparum--cloning, expression and characterization of the malarial enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Kinetic factors that control the fate of thiyl radicals in cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Glutathione reductase-deficient erythrocytes as host cells of malarial parasites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.063

Low red blood cell glutathione reductase and pyridoxine phosphate oxidase activities not related to dietary riboflavin: selection by malaria?

21 January 2018

1

1 reference

Heme degradation in the presence of glutathione. A proposed mechanism to account for the high levels of non-heme iron found in the membranes of hemoglobinopathic red blood cells

3 January 2024

5

1 reference

Plasmodium falciparum glutathione metabolism and growth are independent of glutathione system of host erythrocyte

3 January 2024

8

1 reference

Inhibition of glutathione reductase by dinitrosyl-iron-dithiolate complex

3 January 2024

19

1 reference

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3 January 2024

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Status of Plasmodium falciparum towards catalase

3 January 2024

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3 January 2024

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3 January 2024

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PICOT-HD: a highly conserved protein domain that is often associated with thioredoxin and glutaredoxin modules

3 January 2024

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A crystallographic study of the glutathione binding site of glutathione reductase at 0.3-nm resolution

3 January 2024

70

1 reference

Dinitrosyl-dithiol-iron complexes, nitric oxide (NO) carriers in vivo, as potent inhibitors of human glutathione reductase and glutathione-S-transferase

3 January 2024

73

1 reference

Host responses to Plasmodium yoelii hepatic stages: a paradigm in host-parasite interaction

3 January 2024

79

1 reference

The yeast Saccharomyces cerevisiae contains two glutaredoxin genes that are required for protection against reactive oxygen species.

3 January 2024

84

1 reference

Glutathione transferases--structure and catalytic activity

3 January 2024

86

1 reference

Reduced glutathione in combination with superoxide dismutase as an important biological antioxidant defence mechanism

3 January 2024

95

1 reference

Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress

3 January 2024

100

1 reference

Plasmodium falciparum: inhibitor sensitivity of the endogenous superoxide dismutase

3 January 2024

107

1 reference

Grx5 glutaredoxin plays a central role in protection against protein oxidative damage in Saccharomyces cerevisiae

3 January 2024

110

1 reference

Malarial parasite hexokinase and hexokinase-dependent glutathione reduction in the Plasmodium falciparum-infected human erythrocyte.

3 January 2024

112

1 reference

NADP-specific isocitrate dehydrogenase from the simian malaria parasite Plasmodium knowlesi: partial purification and characterization

3 January 2024

117

1 reference

Disulfide-Reductase Inhibitors as Chemotherapeutic Agents: The Design of Drugs for Trypanosomiasis and Malaria

3 January 2024

121

1 reference

Inhibition of human glutathione reductase by 10-arylisoalloxazines: crystalline, kinetic, and electrochemical studies

3 January 2024

122

1 reference

Lipid peroxidation in Plasmodium falciparum-parasitized human erythrocytes

3 January 2024

128

1 reference

Regulation of gamma-glutamylcysteine synthetase by protein phosphorylation

3 January 2024

132

1 reference

D-lactate production in erythrocytes infected with Plasmodium falciparum

3 January 2024

138

1 reference

Antimalarial dyes revisited: xanthenes, azines, oxazines, and thiazines

3 January 2024

140

1 reference

NADP-specific glutamate dehydrogenase from Plasmodium chabaudi

3 January 2024

142

1 reference

Glutathione reductase: solvent equilibrium and kinetic isotope effects

3 January 2024

145

1 reference

Glutathione reductase inhibitors as potential antimalarial drugs. Effects of nitrosoureas on Plasmodium falciparum in vitro

3 January 2024

146

1 reference

3 January 2024

Identifiers

DOI

10.1515/BC.2003.063

1 reference

31 July 2017

1 reference