Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor. (Q34196324)

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6 February 2020

review article

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title

Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor (English)

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6 February 2020

1

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6 February 2020

Rens de Groot

2

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6 February 2020

Yaozu Xiang

3

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6 February 2020

Brenda M Luken

4

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6 February 2020

author name string

David A Lane

5

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6 February 2020

language of work or name

English

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publication date

29 June 2011

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6 February 2020

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6 February 2020

volume

118

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6 February 2020

page(s)

3212-3221

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6 February 2020

issue

12

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Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13).

6 February 2020

cites work

1 reference

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28 July 2018

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Inactivation of ADAMTS13 by plasmin as a potential cause of thrombotic thrombocytopenic purpura.

28 July 2018

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The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function

28 July 2018

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Amino acid residues Arg(659), Arg(660), and Tyr(661) in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor.

28 July 2018

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An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF

28 July 2018

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Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor

28 July 2018

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Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor

28 July 2018

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The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation

28 July 2018

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Three-dimensional domain architecture of the ADAM family proteinases

28 July 2018

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Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura

28 July 2018

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Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity

28 July 2018

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Basal secretion of von Willebrand factor from human endothelial cells

28 July 2018

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Evidence that high von Willebrand factor and low ADAMTS-13 levels independently increase the risk of a non-fatal heart attack

28 July 2018

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Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

28 July 2018

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High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)

28 July 2018

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Platelet-VWF complexes are preferred substrates of ADAMTS13 under fluid shear stress

28 July 2018

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Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteine-rich domains

28 July 2018

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The cooperative activity between the carboxyl-terminal TSP1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow

28 July 2018

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Shear-induced unfolding triggers adhesion of von Willebrand factor fibers

28 July 2018

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An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimers

28 July 2018

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Further characterization of ADAMTS-13 inactivation by thrombin

28 July 2018

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Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease

28 July 2018

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Characterization of a core binding site for ADAMTS-13 in the A2 domain of von Willebrand factor.

28 July 2018

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ADAMTS13 substrate recognition of von Willebrand factor A2 domain

28 July 2018

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The proximal carboxyl-terminal domains of ADAMTS13 determine substrate specificity and are all required for cleavage of von Willebrand factor.

28 July 2018

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Bombay phenotype is associated with reduced plasma-VWF levels and an increased susceptibility to ADAMTS13 proteolysis

28 July 2018

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FRETS-VWF73, a first fluorogenic substrate for ADAMTS13 assay

28 July 2018

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Fatal congenital thrombotic thrombocytopenic purpura with apparent ADAMTS13 inhibitor: in vitro inhibition of ADAMTS13 activity by hemoglobin

28 July 2018

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Identification of strain-specific variants of mouse Adamts13 gene encoding von Willebrand factor-cleaving protease

28 July 2018

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Epitope mapping of ADAMTS13 autoantibodies in acquired thrombotic thrombocytopenic purpura

28 July 2018

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VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for ADAMTS-13

28 July 2018

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Cleavage of von Willebrand factor requires the spacer domain of the metalloprotease ADAMTS13.

28 July 2018

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ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions

28 July 2018

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Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura

28 July 2018

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Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura

28 July 2018

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Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family

28 July 2018

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Shear-dependent changes in the three-dimensional structure of human von Willebrand factor

28 July 2018

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Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion.

28 July 2018

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Shear stress enhances the proteolysis of von Willebrand factor in normal plasma

28 July 2018

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Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells

28 July 2018

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Biosynthesis of von Willebrand protein by human endothelial cells: processing steps and their intracellular localization

28 July 2018

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Platelets have more than one binding site for von Willebrand factor

28 July 2018

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Involvement of large plasma von Willebrand factor (vWF) multimers and unusually large vWF forms derived from endothelial cells in shear stress-induced platelet aggregation

28 July 2018

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Structural basis of von Willebrand factor binding to platelet glycoprotein Ib and collagen. Effects of disulfide reduction and limited proteolysis of polymeric von Willebrand factor

28 July 2018

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28 July 2018

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28 July 2018

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Induction of specific storage organelles by von Willebrand factor propolypeptide

28 July 2018

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Vicinal cysteines in the prosequence play a role in von Willebrand factor multimer assembly

28 July 2018

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Specific N-linked glycosylation sites modulate synthesis and secretion of von Willebrand factor

28 July 2018

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Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13.

28 October 2018

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28 October 2018

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A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF.

28 October 2018

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Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor

28 October 2018

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ADAMTS13 binds to CD36: a potential mechanism for platelet and endothelial localization of ADAMTS13.

28 October 2018

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Essential role of the disintegrin-like domain in ADAMTS13 function.

28 October 2018

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A functional calcium-binding site in the metalloprotease domain of ADAMTS13.

28 October 2018

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ADAMTS13 cleavage efficiency is altered by mutagenic and, to a lesser extent, polymorphic sequence changes in the A1 and A2 domains of von Willebrand factor.

28 October 2018

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N-linked glycosylation of VWF modulates its interaction with ADAMTS13.

28 October 2018

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ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men.

28 October 2018

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Human endothelial cells synthesize and release ADAMTS-13.

28 October 2018

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Zinc and calcium ions cooperatively modulate ADAMTS13 activity

28 October 2018

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Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure.

28 October 2018

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Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions

28 October 2018

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Cleavage of ultralarge multimers of von Willebrand factor by C-terminal-truncated mutants of ADAMTS-13 under flow

28 October 2018

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Impact of O-linked glycosylation of the VWF-A1-domain flanking regions on platelet interaction

28 October 2018

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Proteolytic inactivation of ADAMTS13 by thrombin and plasmin.

28 October 2018

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Effects of inflammatory cytokines on the release and cleavage of the endothelial cell-derived ultralarge von Willebrand factor multimers under flow

28 October 2018

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ADAMTS-13 cysteine-rich/spacer domains are functionally essential for von Willebrand factor cleavage

28 October 2018

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A novel human metalloprotease synthesized in the liver and secreted into the blood: possibly, the von Willebrand factor-cleaving protease?

28 October 2018

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Biochemistry and genetics of von Willebrand factor

28 October 2018

1 reference

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Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis.

28 October 2018

1 reference

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Localization of ADAMTS13 to the stellate cells of human liver

28 October 2018

1 reference

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Localization of binding sites within human von Willebrand factor for monomeric type III collagen

28 October 2018

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12 December 2020

Factor VIII binds to von Willebrand factor via its Mr-80,000 light chain

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12 December 2020

The propeptide of von Willebrand factor independently mediates the assembly of von Willebrand multimers

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12 December 2020

Proteolytic cleavage of recombinant type 2A von Willebrand factor mutants R834W and R834Q: inhibition by doxycycline and by monoclonal antibody VP-1

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12 December 2020

Functional imaging of shear-dependent activity of ADAMTS13 in regulating mural thrombus growth under whole blood flow conditions

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12 December 2020

Circulating ADAMTS-13-von Willebrand factor complexes: an enzyme on demand

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12 December 2020

The plasma von Willebrand factor O-glycome comprises a surprising variety of structures including ABH antigens and disialosyl motifs

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12 December 2020

Interaction of von Willebrand Factor Domain A1 with Platelet Glycoprotein Ibα-(1–289)

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12 December 2020

Localization of Disulfide Bonds in the Cystine Knot Domain of Human von Willebrand Factor

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12 December 2020

10.1182/BLOOD-2011-02-306597

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21715306%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21715306%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference