Cannabidiol potentiates Δ⁹-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats. (Q34192001)

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English	Cannabidiol potentiates Δ⁹-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats.	scientific article

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4 February 2020

Cannabidiol potentiates Δ⁹-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats (English)

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4 February 2020

tetrahydrocannabinol

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inferred from title

pharmacokinetics

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based on heuristic

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10

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4 February 2020

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4 February 2020

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4 February 2020

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4 February 2020

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4 February 2020

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Charlotte Klein

1

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4 February 2020

Emily Karanges

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4 February 2020

Adena Spiro

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4 February 2020

Jarrah Spencer

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4 February 2020

Thanh Huynh

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4 February 2020

Nathan Gunasekaran

7

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4 February 2020

Kelly Liu

11

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4 February 2020

Jonathon C Arnold

12

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4 February 2020

publication date

11 June 2011

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4 February 2020

Psychopharmacology

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4 February 2020

218

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4 February 2020

2

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4 February 2020

443-457

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4 February 2020

Cannabidiol injected into the bed nucleus of the stria terminalis modulates baroreflex activity through 5-HT1A receptors

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Effect of cannabidiol on cytochrome P-450 isozymes

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Chronic Delta9-tetrahydrocannabinol treatment produces antinociceptive tolerance in mice without altering protein kinase A activity in mouse brain and spinal cord

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis

1 reference

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21 January 2018

High-potency cannabis and the risk of psychosis

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Unconditioned and conditioned anxiogenic effects of the cannabinoid receptor agonist CP 55,940 in the social interaction test.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Antianxiety effect of cannabidiol in the elevated plus-maze

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Reintoxication: the release of fat-stored delta(9)-tetrahydrocannabinol (THC) into blood is enhanced by food deprivation or ACTH exposure

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

The effects of antipsychotic drugs administration on 5-HT1A receptor expression in the limbic system of the rat brain

1 reference

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21 January 2018

Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Cannabidiol decreases body weight gain in rats: involvement of CB2 receptors

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Cannabidiol interferes with the effects of Δ9-tetrahydrocannabinol in man

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Subjective and physiological effects after controlled Sativex and oral THC administration

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Plasma Cannabinoid Pharmacokinetics following Controlled Oral Δ9-Tetrahydrocannabinol and Oromucosal Cannabis Extract Administration

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

A behavioural comparison of acute and chronic Delta9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Delta9-tetrahydrocannabinol, but not the endogenous cannabinoid receptor ligand anandamide, produces conditioned place avoidance

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Cannabidiol reverses the reduction in social interaction produced by low dose Delta(9)-tetrahydrocannabinol in rats

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Aversive effects of the synthetic cannabinoid CP 55,940 in rats.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Cannabis potency and contamination: a review of the literature

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Anxiolytic-like effect of cannabidiol in the rat Vogel conflict test

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Cannabidiol attenuates the appetitive effects of Delta 9-tetrahydrocannabinol in humans smoking their chosen cannabis

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study: naturalistic study [corrected].

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of Delta9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extract

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Chronic cannabinoid administration alters cannabinoid receptor binding in rat brain: a quantitative autoradiographic study

1 reference

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21 January 2018

Effect of low doses of delta9-tetrahydrocannabinol and cannabidiol on the extinction of cocaine-induced and amphetamine-induced conditioned place preference learning in rats

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin

1 reference

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21 January 2018

Potency of delta 9-THC and other cannabinoids in cannabis in England in 2005: implications for psychoactivity and pharmacology

1 reference

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21 January 2018

Adolescent rats find repeated Delta(9)-THC less aversive than adult rats but display greater residual cognitive deficits and changes in hippocampal protein expression following exposure

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Cannabinoid-induced alterations in brain disposition of drugs of abuse

1 reference

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21 January 2018

5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol

1 reference

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21 January 2018

Influence of tetrahydrocannabinols (delta8-THC and delta9-THC) on body weight, food, and water intake in rats

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Temporal and site-specific brain alterations in CB1 receptor binding in high fat diet-induced obesity in C57Bl/6 mice

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

The adolescent brain and age-related behavioral manifestations

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Modulation of adipocyte biology by δ(9)-tetrahydrocannabinol

1 reference

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21 January 2018

Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro

1 reference

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21 January 2018

Divergent effects of cannabidiol on the discriminative stimulus and place conditioning effects of Delta(9)-tetrahydrocannabinol

1 reference

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21 January 2018

Interactions between THC and cannabidiol in mouse models of cannabinoid activity

1 reference

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21 January 2018

Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors

1 reference

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21 January 2018

Cannabinoid administration increases 5HT1A receptor binding and mRNA expression in the hippocampus of adult but not adolescent rats

1 reference

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21 January 2018

Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects

1 reference

https://api.crossref.org/works/10.1007%2FS00213-011-2342-0

21 January 2018

Effect of cannabidiol pretreatment on the kinetics of tetrahydrocannabinol metabolites in mouse brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21667074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological interaction between cannabidiol and delta 9-tetrahydrocannabinol

1 reference

https://pubmed.ncbi.nlm.nih.gov/21667074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modification of ?9-THC-actions by cannabinol and cannabidiol in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/21667074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A metabolic interactionin vivobetween cannabidiol and Δ1-tetrahydrocannabinol

1 reference

https://pubmed.ncbi.nlm.nih.gov/21667074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inactivation of mouse liver cytochrome P-450IIIA by cannabidiol

1 reference

https://pubmed.ncbi.nlm.nih.gov/21667074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological characterization of cannabinoids in the elevated plus maze

1 reference

https://pubmed.ncbi.nlm.nih.gov/21667074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characteristics of the stimulus produced by the mixture of cannabidiol with delta 9-tetrahydrocannabinol

1 reference

https://pubmed.ncbi.nlm.nih.gov/21667074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cannabinoid agonist HU 210 modifies rat behavioural responses to novelty and stress.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21667074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cannabis based drug is licensed for spasticity in patients with MS

1 reference

https://pubmed.ncbi.nlm.nih.gov/21667074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic delta9-tetrahydrocannabinol treatment produces a time-dependent loss of cannabinoid receptors and cannabinoid receptor-activated G proteins in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/21667074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions of several cannabinoids with the hepatic drug metabolizing system

1 reference

https://pubmed.ncbi.nlm.nih.gov/21667074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization of the major hepatic cannabinoid hydroxylase in the mouse: a possible member of the cytochrome P-450IIC subfamily

1 reference

https://pubmed.ncbi.nlm.nih.gov/21667074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions in man of delta-9-tetrahydrocannabinol; II. Cannabinol and cannabidiol

1 reference

https://pubmed.ncbi.nlm.nih.gov/21667074

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00213-011-2342-0

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21667074%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

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Europe PubMed Central

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4 February 2020

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