The multiple paradoxes of presenilins (Q34190161)

31 July 2017

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title

The multiple paradoxes of presenilins (English)

1 reference

31 July 2017

Checler F

1

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PubMed ID

11259479

31 July 2017

language of work or name

English

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publication date

1 March 2001

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Journal of Neurochemistry

31 July 2017

7

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based on heuristic

inferred from page(s)

published in

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31 July 2017

76

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31 July 2017

6

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31 July 2017

1621-1627

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Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease

31 July 2017

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Presenilins: multifunctional proteins involved in Alzheimer's disease pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

The structure and function of the aspartic proteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Mice lacking both presenilin genes exhibit early embryonic patterning defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

The presenilins and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Effects of PS1 deficiency on membrane protein trafficking in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

The molecular pathology of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Beta-amyloid precursor protein cleavage by a membrane-bound protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Presenilins and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1471-4159.2001.00244.X

10.1046/J.1471-4159.2001.00244.X

21 January 2018

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

11259479