PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein (Q34186659)

31 July 2017

PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein (English)

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31 July 2017

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C G Li

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31 July 2017

J E Nyman

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2

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31 July 2017

A W Braithwaite

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3

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31 July 2017

M R Eccles

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31 July 2017

language of work or name

English

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publication date

23 May 2011

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31 July 2017

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31 July 2017

30

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48

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31 July 2017

4824-4834

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https://scigraph.springernature.com/pub.10.1038/onc.2011.190

31 July 2017

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cites work

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Lysine methylation regulates the pRb tumour suppressor protein

5 July 2018

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Is there such a thing as a renal stem cell?

5 July 2018

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5 July 2018

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PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma

5 July 2018

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A rapid micro chromatin immunoprecipitation assay (microChIP).

5 July 2018

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5 July 2018

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DNA-damage response control of E2F7 and E2F8

5 July 2018

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Mechanisms controlling cell cycle exit upon terminal differentiation

5 July 2018

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Successful co-immunoprecipitation of Oct4 and Nanog using cross-linking

5 July 2018

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Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney

5 July 2018

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Regulation of cell lineage specification by the retinoblastoma tumor suppressor

5 July 2018

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Stabilization of the retinoblastoma protein by A-type nuclear lamins is required for INK4A-mediated cell cycle arrest

5 July 2018

1 reference

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PAX2 inactivation enhances cisplatin-induced apoptosis in renal carcinoma cells

5 July 2018

1 reference

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Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase

5 July 2018

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MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein.

5 July 2018

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Differential gene expression in ovarian carcinoma: identification of potential biomarkers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Molecular mechanisms of E2F-dependent activation and pRB-mediated repression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Genomic targets of the human c-Myc protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Identification of novel pRb binding sites using CpG microarrays suggests that E2F recruits pRb to specific genomic sites during S phase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Nephric lineage specification by Pax2 and Pax8

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Pax-2 expression in adult renal tumors.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Autosomal dominant transmission of congenital thyroid hypoplasia due to loss-of-function mutation of PAX8

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Human thyroid cancer cells as a source of iso-genic, iso-phenotypic cell lines with or without functional p53

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

The paired-domain transcription factor Pax8 binds to the upstream enhancer of the rat sodium/iodide symporter gene and participates in both thyroid-specific and cyclic-AMP-dependent transcription

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Pax-8 protein levels regulate thyroglobulin gene expression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

The regulation of E2F by pRB-family proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Follicular cells of the thyroid gland require Pax8 gene function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis

5 July 2018

1 reference

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PAX 8 activates the enhancer of the human thyroperoxidase gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

The human papillomavirus E7 oncoprotein functionally interacts with the S4 subunit of the 26 S proteasome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Pax genes and organogenesis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Concentration of RB protein in nucleus vs. cytoplasm is stable as phosphorylation of RB changes during the cell cycle and differentiation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Comparative in situ hybridization analysis of PAX2, PAX8, and WT1 gene transcription in human fetal kidney and Wilms' tumors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Distinct functional properties of three human paired-box-protein, PAX8, isoforms generated by alternative splicing in thyroid, kidney and Wilms' tumors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

The retinoblastoma protein and cell cycle control

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Function of the homeo and paired domain proteins TTF-1 and Pax-8 in thyroid cell proliferation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

The E2F transcription factor is a cellular target for the RB protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

Emerging roles for PAX8 in ovarian cancer and endosalpingeal development.

5 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.190

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.190

A role for Myc in facilitating transcription activation by E2F1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.190

Stem cell therapies benefit Alport syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.190

Primary extragastrointestinal stromal tumor of the pleura: report of a unique case with genetic confirmation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.190

Retinoblastoma protein acts as Pax 8 transcriptional coactivator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.190

Escape from premature senescence is not sufficient for oncogenic transformation by Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.190

Disruption of base-paired U4.U6 small nuclear RNAs induced by mammalian heterogeneous nuclear ribonucleoprotein C protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.190

Roles of Pax-genes in developing and adult brain as suggested by expression patterns.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3229668

PAX2: a reliable marker for nephrogenic adenoma

28 October 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.190

PAX3 Is extensively expressed in benign and malignant tissues of the melanocytic lineage in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.190

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.190

Expression of PAX8 in normal and neoplastic renal tissues: an immunohistochemical study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.190

Immunohistochemical analysis of thyroid-specific transcription factors in thyroid tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.190

Acetylation control of the retinoblastoma tumour-suppressor protein

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21602887

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

PAX8 Expression in Well-differentiated Pancreatic Endocrine Tumors: Correlation With Clinicopathologic Features and Comparison With Gastrointestinal and Pulmonary Carcinoid Tumors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21602887

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2011.190

1 reference

Dimensions Publication ID

31 July 2017

0 references

1 reference

31 July 2017

1 reference