Problems of reporting genetic associations with complex outcomes (Q34184173)

31 July 2017

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title

Problems of reporting genetic associations with complex outcomes (English)

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31 July 2017

3

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31 July 2017

Helen M Colhoun

1

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author name string

Paul M McKeigue

series ordinal

2

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PubMed ID

12642066

31 July 2017

language of work or name

English

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publication date

1 March 2003

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31 July 2017

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31 July 2017

361

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31 July 2017

865-872

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31 July 2017

9360

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Replication validity of genetic association studies

31 July 2017

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Parameters for reliable results in genetic association studies in common disease

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

1 reference

7 January 2021

Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Association of the alpha-adducin locus with essential hypertension

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Alpha-adducin gene polymorphism and cardiovascular phenotypes in a general population

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Human alpha-adducin gene, blood pressure, and sodium metabolism

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

No association between alpha-adducin 460 polymorphism and essential hypertension in a Japanese population.

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Lack of association between the alpha-adducin locus and essential hypertension in the Japanese population

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Lack of association between a biallelic polymorphism in the adducin gene and blood pressure in whites and African Americans

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Association and linkage analysis of the alpha-adducin gene and blood pressure

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Lack of evidence for an association between alpha-adducin and blood pressure regulation in Asian populations.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

All for one and one for all: introduction to a coordinated analysis of the Gly-460-Trp alpha-adducin polymorphism

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Association study designs for complex diseases

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Association studies of genetic polymorphisms and complex disease

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Maneuvering in the complex path from genotype to phenotype

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Putting the search for genes in perspective

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Trials of the beta model for complex inheritance

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Linkage disequilibrium mapping of complex disease: fantasy or reality?

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

On the allelic spectrum of human disease

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Association and linkage analysis of alpha-adducin polymorphism: is the glass half full or half empty?

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

The replication requirement

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Global patterns of linkage disequilibrium at the CD4 locus and modern human origins

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Linkage disequilibrium in the human genome

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

The frequent 5,10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in whites, Japanese, and Africans

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Epidemiological methods for studying genes and environmental factors in complex diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Tests and estimates of allelic association in complex inheritance

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Patterns of linkage disequilibrium in the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Reporting, appraising, and integrating data on genotype prevalence and gene-disease associations

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Population stratification in epidemiologic studies of common genetic variants and cancer: quantification of bias

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Association mapping in structured populations

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

The future of genetic studies of complex human diseases

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls. International Studies of Infarct Survival (ISIS) Collaborators

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Large upward bias in estimation of locus-specific effects from genomewide scans

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

A meta-analysis of the association of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

The deletion/insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular-renal risk

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

ACE gene polymorphism in cardiovascular disease: meta-analyses of small and large studies in whites

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Where now for meta-analysis?

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Bias in meta-analysis detected by a simple, graphical test

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Genetic Polymorphisms and Disease

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

p values, hypothesis tests, and likelihood: implications for epidemiology of a neglected historical debate.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Sifting the evidence-what's wrong with significance tests?

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

Haplotype tagging for the identification of common disease genes

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

On the relative sample size required for multiple comparisons.

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https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2912715-8

7 January 2021

10.1016/S0140-6736(03)12715-8

Identifiers

DOI

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31 July 2017

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PubMed ID

12642066