PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury. (Q34182576)

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14 February 2020

title

PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury (English)

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14 February 2020

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8

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7

Leonard I Zon

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14 February 2020

author name string

Trista E North

1

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14 February 2020

I Ramesh Babu

2

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14 February 2020

Lea M Vedder

3

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14 February 2020

Allegra M Lord

4

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John S Wishnok

5

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Steven R Tannenbaum

6

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language of work or name

English

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publication date

20 September 2010

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Proceedings of the National Academy of Sciences of the United States of America

14 February 2020

published in

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volume

107

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14 February 2020

page(s)

17315-17320

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issue

40

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The role of prostaglandin E2 in acute acetaminophen hepatotoxicity in mice

14 February 2020

cites work

1 reference

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Beta-catenin activation promotes liver regeneration after acetaminophen-induced injury

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Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration

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APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development

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Comparison of S-adenosyl-L-methionine (SAMe) and N-acetylcysteine (NAC) protective effects on hepatic damage when administered after acetaminophen overdose

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Investigation of proteomic biomarkers in in vivo hepatotoxicity study of rat liver: toxicity differentiation in hepatotoxicants

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A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction

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Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes

28 July 2018

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In vivo studies of liver-type fatty acid binding protein (L-FABP) gene expression in liver of transgenic zebrafish (Danio rerio).

28 July 2018

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Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity

28 July 2018

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A transgenic Lef1/beta-catenin-dependent reporter is expressed in spatially restricted domains throughout zebrafish development.

28 July 2018

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Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration

28 July 2018

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Safety and efficacy of intravenous N-acetylcysteine for acetaminophen overdose: analysis of the Hunter Area Toxicology Service (HATS) database.

21 January 2018

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Genomics and proteomics analysis of acetaminophen toxicity in mouse liver

21 January 2018

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Proteomic identification of potential susceptibility factors in drug-induced liver disease

21 January 2018

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Diverse antioxidants protect against acetaminophen hepatotoxicity

21 January 2018

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Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.

21 January 2018

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Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury

21 January 2018

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Analysis of the Albumin/alpha-Fetoprotein/Afamin/Group specific component gene family in the context of zebrafish liver differentiation

21 January 2018

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The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model

21 January 2018

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12 December 2020

Role of apolipoprotein D in the transport of bilirubin in plasma

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12 December 2020

Role of CYP2E1 in the hepatotoxicity of acetaminophen

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12 December 2020

Inactivation of glyceraldehyde-3-phosphate dehydrogenase by a reactive metabolite of acetaminophen and mass spectral characterization of an arylated active site peptide

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Identifiers

DOI

10.1073/PNAS.1008209107

1 reference

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14 February 2020

0 references

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14 February 2020

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