Genetic risks of antiviral nucleoside analogues--a survey (Q34180549)

31 July 2017

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title

Genetic risks of antiviral nucleoside analogues--a survey (English)

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31 July 2017

Wutzler P

1

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PubMed ID

11248359

31 July 2017

Thust R

series ordinal

2

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31 July 2017

1 February 2001

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31 July 2017

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31 July 2017

49

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31 July 2017

55-74

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31 July 2017

2

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Nonclinical toxicology studies with zidovudine: genetic toxicity tests and carcinogenicity bioassays in mice and rats

31 July 2017

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Effects of (E)-5-(2-bromovinyl)-2′-deoxyuridine on the proliferation of herpes simplex virus type 1-transformed and thymidine kinase-deficient mouse cells

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Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group

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Lack of long-term effects of in utero exposure to zidovudine among uninfected children born to HIV-infected women. Pediatric AIDS Clinical Trials Group Protocol 219/076 Teams.

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Varicella-zoster virus thymidine kinase gene and antiherpetic pyrimidine nucleoside analogues in a combined gene/chemotherapy treatment for cancer.

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Multiorgan transplacental and neonatal carcinogenicity of 3'-azido-3'-deoxythymidine in mice

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Protection against AZT-induced mutagenesis at the HGPRT locus in a human cell line by WR-151326

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Lack of tumors in infants with perinatal HIV-1 exposure and fetal/neonatal exposure to zidovudine

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Comparative in-vivo genotoxicity of antiviral nucleoside analogues; penciclovir, acyclovir, ganciclovir and the xanthine analogue, caffeine, in the mouse bone marrow micronucleus assay

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Cell transformation by chemical agents--a review and analysis of the literature. A report of the U.S. Environmental Protection Agency Gene-Tox Program

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Behavior of estrogen-associated female genital tract cancer and its relation to neoplasia following intrauterine exposure to diethylstilbestrol (DES).

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Acyclic guanosine analogs inhibit DNA polymerases alpha, delta, and epsilon with very different potencies and have unique mechanisms of action

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Structure-activity relationships and conformational features of antiherpetic pyrimidine and purine nucleoside analogues. A review

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International Commission for Protection Against Environmental Mutagens and Carcinogens. Deoxyribonucleoside triphosphate levels: a critical factor in the maintenance of genetic stability

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Potent anti-viral 5-(2-bromovinyl) uracil nucleosides are inactive at inducing gene mutations in Salmonella typhimurium and V79 Chinese hamster cells and unscheduled DNA synthesis in primary rat hepatocytes.

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Chiral chemical synthesis of DNA containing (S)-9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) and effects on thermal stability, duplex structure, and thermodynamics of duplex formation

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Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis

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Relationships between DNA incorporation, mutant frequency, and loss of heterozygosity at the TK locus in human lymphoblastoid cells exposed to 3'-azido-3'-deoxythymidine

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Lack of induction of micronuclei by azidothymidine (AZT) in vivo in mouse bone marrow cells

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7 January 2021

Transplacental effects of 3'-azido-2',3'-dideoxythymidine (AZT): tumorigenicity in mice and genotoxicity in mice and monkeys.

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3'-azido-3'-deoxythymidine (AZT) transplacental perfusion kinetics and DNA incorporation in normal human placentas perfused with AZT

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Incorporation of zidovudine into leukocyte DNA from HIV-1-positive adults and pregnant women, and cord blood from infants exposed in utero

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Genotoxic properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU).

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Induction of micronuclei in mouse bone marrow cells: an evaluation of nucleoside analogues used in the treatment of AIDS.

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A mammalian cell line designed to test the mutagenic activity of anti-herpes nucleosides

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Monitoring of occupational exposure to cytostatic anticancer agents.

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Inhibition by ganciclovir of cell growth and DNA synthesis of cells biochemically transformed with herpesvirus genetic information

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Genotoxicity of 3'-azido-3'-deoxythymidine in the human lymphoblastoid cell line, TK6: relationships between DNA incorporation, mutant frequency, and spectrum of deletion mutations in HPRT

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Cytogenetic genotoxicity of antiherpes virostatics in Chinese hamster V79-E cells. I. Purine nucleoside analogues

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Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thymidine kinase gene of herpes simplex virus-1: implications for gene therapeutic approaches

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Cytogenetic genotoxicity of anti-herpes purine nucleoside analogues in CHO cells expressing the thymidine kinase gene of herpes simplex virus type 1: comparison of ganciclovir, penciclovir and aciclovir

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Preclinical toxicology studies with acyclovir: carcinogenicity bioassays and chronic toxicity tests

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Deoxyribonucleotide analogs as inhibitors and substrates of DNA polymerases

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7 January 2021

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Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

11248359