Orphan G-protein-coupled receptors and natural ligand discovery (Q34175467)

31 July 2017

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title

Orphan G-protein-coupled receptors and natural ligand discovery (English)

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G protein-coupled receptor

31 July 2017

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author name string

Howard AD

1

1 reference

31 July 2017

McAllister G

2

1 reference

31 July 2017

Feighner SD

3

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31 July 2017

Liu Q

4

1 reference

31 July 2017

Nargund RP

5

1 reference

31 July 2017

Van der Ploeg LH

6

1 reference

31 July 2017

Patchett AA

7

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31 July 2017

1 March 2001

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Trends in Pharmacological Sciences

31 July 2017

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31 July 2017

22

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31 July 2017

132-140

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31 July 2017

3

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Molecular tinkering of G protein-coupled receptors: an evolutionary success

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Heptahelical receptor signaling: beyond the G protein paradigm.

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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Sequence alignment of the G-protein coupled receptor superfamily

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https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Physiological regulation of G protein-linked signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Seven-transmembrane proteins as odorant and chemosensory receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Ghrelin: a step forward in the understanding of somatotroph cell function and growth regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Discovering new hormones, receptors, and signaling mediators in the genomic era.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Orphan receptors, novel neuropeptides and reverse pharmaceutical research

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Functional genomics: the search for novel neurotransmitters and neuropeptides

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Orphan G-protein-coupled receptors: the next generation of drug targets?

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

RAMPs: accessory proteins for seven transmembrane domain receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Debating controversies can enhance creativity

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

GABAB receptors make it to the top--as dimers

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

G-protein-coupled receptor heterodimerization modulates receptor function

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

EDG3 is a functional receptor specific for sphingosine 1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDG1 and AGR16

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Sphingosine 1-phosphate signalling in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Cloning and functional expression of the human histamine H3 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

RDC8 codes for an adenosine A2 receptor with physiological constitutive activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Hypocretin (orexin) deficiency in human narcolepsy.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Current developments in G-protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Tools for investigating functional interactions between ligands and G-protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Chimaeric G alpha proteins: their potential use in drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Controlling signaling with a specifically designed Gi-coupled receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

G16 as a universal G protein adapter: implications for agonist screening strategies.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

A receptor in pituitary and hypothalamus that functions in growth hormone release

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

A cDNA encoding the calcitonin gene-related peptide type 1 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Molecular cloning and characterization of the human anaphylatoxin C3a receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

A prolactin-releasing peptide in the brain

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Cloning and characterization of a new subtype of thyrotropin-releasing hormone receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Cloning and characterization of a cDNA encoding a novel subtype of rat thyrotropin-releasing hormone receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Characterization of the human cysteinyl leukotriene CysLT1 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Characterization of the human cysteinyl leukotriene 2 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Receptor for motilin identified in the human gastrointestinal system

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Molecular characterization of the melanin-concentrating-hormone receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Isolation and identification of melanin-concentrating hormone as the endogenous ligand of the SLC-1 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Identification of melanin concentrating hormone (MCH) as the natural ligand for the orphan somatostatin-like receptor 1 (SLC-1).

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Urotensin II is the endogenous ligand of a G-protein-coupled orphan receptor, SENR (GPR14).

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Characterization of a novel sphingosine 1-phosphate receptor, Edg-8

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Reverse physiology in drosophila: identification of a novel allatostatin-like neuropeptide and its cognate receptor structurally related to the mammalian somatostatin/galanin/opioid receptor family

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Molecular cloning and genomic organization of a second probable allatostatin receptor from Drosophila melanogaster.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

A G protein-coupled receptor for UDP-glucose

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Identification of receptors for neuromedin U and its role in feeding

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Identification and functional characterization of a novel subtype of neuromedin U receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Identification of a novel neuromedin U receptor subtype expressed in the central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Identification of a human gastrointestinal tract and immune system receptor for the peptide neuromedin U

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Identification and characterization of two G protein-coupled receptors for neuropeptide FF

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Overview of the most prevalent hypothalamus-specific mRNAs, as identified by directional tag PCR subtraction

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

The hypocretin/orexin story.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Growth hormone-releasing peptide (GHRP).

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Peptidomimetic regulation of growth hormone secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

New 4-point pharmacophore method for molecular similarity and diversity applications: overview of the method and applications, including a novel approach to the design of combinatorial libraries containing privileged substructures

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Identification of a new G-protein-linked receptor for growth hormone secretagogues

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Ligand activation domain of human orphan growth hormone (GH) secretagogue receptor (GHS-R) conserved from Pufferfish to humans

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Purification and characterization of rat des-Gln14-Ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

Adenosine: A partial agonist of the growth hormone secretagogue receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2800%2901636-9

7 January 2021

10.1016/S0165-6147(00)01636-9

Identifiers

DOI

1 reference

release_2slg6qk2gvg25gqmcn4ndaegfm

31 July 2017

1 reference

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https://api.fatcat.wiki/v0/release/2slg6qk2gvg25gqmcn4ndaegfm

24 November 2022

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