The 3'-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein (Q34158996)

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English	The 3'-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein	scientific article

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scholarly article

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Europe PubMed Central

31 July 2017

The 3'-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein (English)

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Europe PubMed Central

31 July 2017

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Keith M Giles

1

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Europe PubMed Central

31 July 2017

John M Daly

2

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Europe PubMed Central

31 July 2017

Dianne J Beveridge

3

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Europe PubMed Central

31 July 2017

Andrew M Thomson

4

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Europe PubMed Central

31 July 2017

Dominic C Voon

5

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Europe PubMed Central

31 July 2017

Henry M Furneaux

6

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Europe PubMed Central

31 July 2017

Jalal A Jazayeri

7

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Europe PubMed Central

31 July 2017

Peter J Leedman

8

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31 July 2017

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publication date

12 November 2002

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31 July 2017

number of pages

10

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Journal of Biological Chemistry

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31 July 2017

278

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31 July 2017

2937-2946

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Europe PubMed Central

31 July 2017

5

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Europe PubMed Central

31 July 2017

WAF1, a potential mediator of p53 tumor suppression

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A cell cycle-regulated inhibitor of cyclin-dependent kinases

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Mutations in the p53 gene occur in diverse human tumour types

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Modulation of cyclic AMP accumulation in GH3 cells by a phorbol ester and thyroliberin

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Prolonged induction of p21Cip1/WAF1/CDK2/PCNA complex by epidermal growth factor receptor activation mediates ligand-induced A431 cell growth inhibition

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p21WAF1 expression by an activator of protein kinase C is regulated mainly at the post-transcriptional level in cells lacking p53: important role of RNA stabilization

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21 January 2018

p53-dependent elevation of p21Waf1 expression by UV light is mediated through mRNA stabilization and involves a vanadate-sensitive regulatory system

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Epidermal growth factor increases the level of the cyclin-dependent kinase (CDK) inhibitor p21/CIP1 (CDK-interacting protein 1) in A431 cells by increasing the half-lives of the p21/CIP1 transcript and the p21/CIP1 protein

1 reference

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21 January 2018

HuR regulates p21 mRNA stabilization by UV light

1 reference

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MRNA stability and the control of gene expression: implications for human disease

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Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements

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A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation

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AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/A).

1 reference

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The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation

1 reference

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The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms

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AUH, a gene encoding an AU-specific RNA binding protein with intrinsic enoyl-CoA hydratase activity

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Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein

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Purification and properties of HuD, a neuronal RNA-binding protein.

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Preferential binding of poly(A)-binding protein 1 to an inhibitory RNA element in the human immunodeficiency virus type 1 gag mRNA.

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Why is Hu where? Shuttling of early-response-gene messenger RNA subsets

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HNS, a nuclear-cytoplasmic shuttling sequence in HuR

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Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs

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Identification of HuR as a protein implicated in AUUUA-mediated mRNA decay

1 reference

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p21(waf1) mRNA contains a conserved element in its 3'-untranslated region that is bound by the Elav-like mRNA-stabilizing proteins.

1 reference

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Production of high-titer helper-free retroviruses by transient transfection

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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

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An AU-rich sequence in the 3'-UTR of plasminogen activator inhibitor type 2 (PAI-2) mRNA promotes PAI-2 mRNA decay and provides a binding site for nuclear HuR.

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Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA.

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Alpha(1) adrenergic agonist induction of p21(waf1/cip1) mRNA stability in transfected HepG2 cells correlates with the increased binding of an AU-rich element binding factor

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Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytes

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Detection and characterization of a 3' untranslated region ribonucleoprotein complex associated with human alpha-globin mRNA stability

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Regulation of tyrosine hydroxylase mRNA stability by protein-binding, pyrimidine-rich sequence in the 3'-untranslated region

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Characterization of the hypoxia-inducible protein binding site within the pyrimidine-rich tract in the 3'-untranslated region of the tyrosine hydroxylase mRNA.

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Identifiers

10.1074/JBC.M208439200

1 reference

Europe PubMed Central

31 July 2017

1 reference

Europe PubMed Central

31 July 2017

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