Synthesis of cortistatins A, J, K and L. (Q34157313)

31 July 2017

Synthesis of cortistatins A, J, K and L. (English)

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31 July 2017

Alec N Flyer

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31 July 2017

Chong Si

series ordinal

2

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31 July 2017

Andrew G Myers

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3

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31 July 2017

1 August 2010

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31 July 2017

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31 July 2017

2

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31 July 2017

10

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31 July 2017

886-892

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https://scigraph.springernature.com/pub.10.1038/nchem.794

31 July 2017

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A hypervalent iodine-induced double annulation enables a concise synthesis of the pentacyclic core structure of the cortistatins

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A novel α,β-unsaturated nitrone-aryne [3+2] cycloaddition and its application in the synthesis of the cortistatin core

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Cortistatin A is a high-affinity ligand of protein kinases ROCK, CDK8, and CDK11.

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Total synthesis and biological evaluation of cortistatins A and J and analogues thereof.

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Stereodivergent synthesis of 17-alpha and 17-beta-alpharyl steroids: application and biological evaluation of D-ring cortistatin analogues

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5 July 2018

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12 December 2020

A Concise Synthesis of the Pentacyclic Framework of Cortistatins

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12 December 2020

A short, scalable synthesis of the carbocyclic core of the anti-angiogenic cortistatins from (+)-estrone by B-ring expansion

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12 December 2020

Intramolecular cyclopropene-furan [2 + 4] cycloaddition followed by a cyclopropylcarbinyl rearrangement to synthesize the BCD rings of cortistatin A

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12 December 2020

Reduction of Carbonyl Compounds with Chiral Oxazaborolidine Catalysts: A New Paradigm for Enantioselective Catalysis and a Powerful New Synthetic Method

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Cortistatins E, F, G, and H, four novel steroidal alkaloids from marine sponge Corticium simplex

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7 January 2021

Cortistatins J, K, L, novel abeo-9(10-19)-androstane-type steroidal alkaloids with isoquinoline unit, from marine sponge Corticium simplex

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7 January 2021

A Study of the Entrainment Method for Making Grignard Reagents

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7 January 2021

Reduction of carbonyl compounds via hydrosilylation. 4. Highly regioselective reductions of .alpha.,.beta.-unsaturated carbonyl compounds

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7 January 2021

Identifiers

DOI

10.1038/NCHEM.794

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Dimensions Publication ID

31 July 2017

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31 July 2017

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