The SHP-2 tyrosine phosphatase: signaling mechanisms and biological functions (Q34146819)

31 July 2017

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title

The SHP-2 tyrosine phosphatase: signaling mechanisms and biological functions (English)

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31 July 2017

Qu CK

1

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PubMed ID

11191350

31 July 2017

language of work or name

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1 December 2000

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31 July 2017

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31 July 2017

10

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31 July 2017

279-288

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31 July 2017

4

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https://scigraph.springernature.com/pub.10.1038/sj.cr.7290055

31 July 2017

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cites work

Signaling--2000 and beyond

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

From form to function: signaling by protein tyrosine phosphatases.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Form and function in protein dephosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Molecular cloning of a novel protein‐tyrosine phosphatase SH‐PTP3 with sequence similarity to the src‐homology region 2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Mammalian SH2-containing protein tyrosine phosphatases.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Crystal structure of the tyrosine phosphatase SHP-2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Structural determinants of SHP-2 function and specificity in Xenopus mesoderm induction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Protein tyrosine phosphatases in signal transduction.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Immune signalling: SHP-2 docks at multiple ports

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Roles for the protein tyrosine phosphatase SHP-2 in cytoskeletal organization, cell adhesion and cell migration revealed by overexpression of a dominant negative mutant

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Expression of a dominant negative SHP-2 in transgenic mice induces insulin resistance.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Syp associates with gp130 and Janus kinase 2 in response to interleukin-11 in 3T3-L1 mouse preadipocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Characterization of two SHP-2-associated binding proteins and potential substrates in hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Insulin signaling in mice expressing reduced levels of Syp.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

The SH2 tyrosine phosphatase shp2 is required for mammalian limb development.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Shp-2 has a positive regulatory role in ES cell differentiation and proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Regulation of colony-stimulating factor 1 receptor signaling by the SH2 domain-containing tyrosine phosphatase SHPTP1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Shp-2 mediates v-Src-induced morphological changes and activation of the anti-apoptotic protein kinase Akt.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 are dramatically increased at the protein level in neutrophils from patients with severe congenital neutropenia (Kostmann's syndrome)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Altered expression of insulin signaling components in streptozotocin-treated rats.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CR.7290055

7 January 2021

Identifiers

DOI

10.1038/SJ.CR.7290055

1 reference

PubMed ID

11191350

Dimensions Publication ID

31 July 2017

0 references

1 reference

PubMed ID

11191350